439171. |
- Larsson, Lena, 1969, et al.
(författare)
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Expression of TET2 enzyme indicates enhanced epigenetic modification of cells in periodontitis
- 2016
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Ingår i: European Journal of Oral Sciences. - : Wiley. - 0909-8836. ; 124:4, s. 329-333
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Tidskriftsartikel (refereegranskat)abstract
- DNA methylation is an important epigenetic mechanism involved in the regulation of gene expression, and a reduction in DNA methylation influences cell-cycle progression and cell differentiation in inflammatory cells. The aim of the present study was to analyze the DNA-methylation pattern at local and global/systemic levels in patients with periodontitis and gingivitis. Twenty-one subjects with generalized, severe periodontitis and 17 subjects with gingival inflammation but no attachment loss were recruited. Gingival biopsies and peripheral blood samples were collected and prepared for immunohistochemical analysis of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), ten-eleven translocation 2 (TET2), and DNA methyltransferase 1 (DNMT1). Whilst a similar pattern for 5mC and 5hmC DNA methylation was found in both types of lesions, a significantly larger proportion of TET2-positive cells was found in periodontitis lesions than in gingivitis lesions. Quantitative real-time PCR analysis showed no differences between gingivitis and periodontitis lesions regarding expression of TET2 and isocitrate dehydrogenase (IDH) genes, while the global level of 5hmC was significantly higher in blood than in tissue in patients with periodontitis. It is suggested that epigenetic changes are more common in periodontitis lesions than in gingivitis lesions and that such changes are tissue specific.
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439172. |
- Larsson, Lennart
(författare)
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Femettor och femettor
- 2004
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Ingår i: Upsala nya tidning. - Uppsala : Upsala nya tidning. - 1104-0173.
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Tidskriftsartikel (populärvet., debatt m.m.)
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439173. |
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439174. |
- Larsson, Lennart, 1952-
(författare)
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Florinus ordbok
- 2006
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Ingår i: Språk och stil. - Uppsala. - 1101-1165 .- 2002-4010. ; 16 NF, s. 74-111
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Tidskriftsartikel (refereegranskat)
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439175. |
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439176. |
- Larsson, Larsåke, 1946-
(författare)
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From yearly to daily press meetings : the development of the government press relations in Sweden
- 2012
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Ingår i: Public Relations Inquiry/SAGE. - : Sage Publications. - 2046-147X. ; 1:3, s. 257-283
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Tidskriftsartikel (refereegranskat)abstract
- Emerging with the Second World War, and taking its modern form in the 1970s with Olof Palme, the government press conference has today become an almost daily event in Sweden with frequent informal and impromptu meetings between the assembled press and the prime minister. The history of this phenomenon reveals a development from respectful off-the-record sessions to direct webcasted conferences with PR-minded, policy-selling politicians as well as, at least sometimes, journalists eager to inquire into problematic issues. The initial stage, during the war, was very intense, as Stockholm became a gathering point for international war correspondents. This study, grounded in multidisciplinary relational conceptualizations and using a multidimensional methodology, aims to tell the story of the development of governmental press conferences in Sweden.
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439177. |
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439178. |
- Larsson, Lars
(författare)
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Från mossens botten
- 2004
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Ingår i: ALE. - 0345-0708. ; 2004:3, s. 1-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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439179. |
- Larsson, Lars
(författare)
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Fynden på mossens botten
- 2003
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Ingår i: Arkæologi for alle. Medlemsblad for danske amatørarkæologer. ; 1, s. 5-6
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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439180. |
- Larsson, Lars
(författare)
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För mer än 10.000 år sedan
- 2007
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Ingår i: Våra Härader. - 0281-8981. ; , s. 3-8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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