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Sökning: WFRF:(Höpfner M.) > Höpfner M. > Dupuy E.

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  • Clementsson, Bonnie (författare)
  • Changing patterns of hierarchy within Swedish stepfamilies in the late 1700s
  • 2022
  • Ingår i: History of the Family. - 1081-602X. ; 27:3, s. 546-574
  • Tidskriftsartikel (refereegranskat)abstract
    • Like many other West European countries during the early modern period, Swedish society was structured by a variety of hierarchies and, in this context, the principle of filial deference, or the obedience and recognition children–young or adult–were expected to show their parents, was more or less absolute. These ideas of family hierarchy also influenced marriage laws and the formal rules of who was allowed to marry whom. During the 1700s the number of applications to the Swedish Crown seeking permission to marry from couples who were related to each other in some way increased significantly. Often these requests concerned second marriages and possible constructions of stepfamilies. Through analyses of more than 1000 marriage applications to authorities in Sweden from the early 1700s to the early 1900s, this article will show how notions of the power relations within the families changed towards the end of the 1700s, affecting how different forbidden relationships were perceived and assessed by the authorities. Parental respect was challenged and the unconditional respect for the older generation started to diminish. This cultural shift also affected the possible constellations and structures of stepfamilies even though there had been no change of the formal laws.
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  • Kershaw, Jane, et al. (författare)
  • The scale of dirham imports to the Baltic in the ninth century : new evidence from archaeometric analyses of early Viking-Age silver
  • 2021
  • Ingår i: Fornvännen. - Stockholm : Kungl. Vitterhets Historie och Antikvitets Akademien. - 0015-7813 .- 1404-9430. ; 116:3, s. 185-204
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a high precision, minimally-destructive geochemical (lead isotope and trace element) analysis of nine cast silver items from early Viking-Age hoards from the Baltic. Comparing the data to a large reference dataset comprising Islamic dirhams and ninth-century Western European silver, we find that the artefacts were cast chiefly from recycled Islamic silver. Isotopic modelling reveals, further, that the Islamic silver derives from a stock that entered the central Baltic in the first half of the ninth century. This period has traditionally been characterised as one of low-level dirham import, before the escalation of the dirham trade from c. AD 860/70. Our results suggest instead that dirhams entered the central Balticin significant numbers before c. 850, but were routinely melted down for casting into artefacts. This has two important implications. First, it suggests that the early ninth-century Baltic economy was more closely coupled to Eurasian trade networks than current appreciated. Second, it calls into question the reliance on extant dirhams as a guide to Scandinavia’s engagement in long-distance traderoutes.
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  • Wolf, Jochen B. W., et al. (författare)
  • Speciation genetics : current status and evolving approaches Introduction
  • 2010
  • Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8436 .- 1471-2970. ; 365:1547, s. 1717-1733
  • Tidskriftsartikel (refereegranskat)abstract
    • The view of species as entities subjected to natural selection and amenable to change put forth by Charles Darwin and Alfred Wallace laid the conceptual foundation for understanding speciation. Initially marred by a rudimental understanding of hereditary principles, evolutionists gained appreciation of the mechanistic underpinnings of speciation following the merger of Mendelian genetic principles with Darwinian evolution. Only recently have we entered an era where deciphering the molecular basis of speciation is within reach. Much focus has been devoted to the genetic basis of intrinsic postzygotic isolation in model organisms and several hybrid incompatibility genes have been successfully identified. However, concomitant with the recent technological advancements in genome analysis and a newfound interest in the role of ecology in the differentiation process, speciation genetic research is becoming increasingly open to non-model organisms. This development will expand speciation research beyond the traditional boundaries and unveil the genetic basis of speciation from manifold perspectives and at various stages of the splitting process. This review aims at providing an extensive overview of speciation genetics. Starting from key historical developments and core concepts of speciation genetics, we focus much of our attention on evolving approaches and introduce promising methodological approaches for future research venues
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  • Loryan, Irena, 1977-, et al. (författare)
  • Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery
  • 2014
  • Ingår i: Pharmaceutical research. - : Springer Science and Business Media LLC. - 0724-8741 .- 1573-904X. ; 31:8, s. 2203-2219
  • Tidskriftsartikel (refereegranskat)abstract
    • PurposeThe current project was undertaken with the aim to propose and test an in-depth integrative analysis of neuropharmacokinetic (neuroPK) properties of new chemical entities (NCEs), thereby optimizing the routine of evaluation and selection of novel neurotherapeutics.MethodsForty compounds covering a wide range of physicochemical properties and various CNS targets were investigated. The combinatory mapping approach was used for the assessment of the extent of blood-brain and cellular barriers transport via estimation of unbound-compound brain (Kp,uu,brain) and cell (Kp,uu,cell) partitioning coefficients. Intra-brain distribution was evaluated using the brain slice method. Intra- and sub-cellular distribution was estimated via calculation of unbound-drug cytosolic and lysosomal partitioning coefficients.ResultsAssessment of Kp,uu,brain revealed extensive variability in the brain penetration properties across compounds, with a prevalence of compounds actively effluxed at the blood-brain barrier. Kp,uu,cell was valuable for identification of compounds with a tendency to accumulate intracellularly. Prediction of cytosolic and lysosomal partitioning provided insight into the subcellular accumulation. Integration of the neuroPK parameters with pharmacodynamic readouts demonstrated the value of the proposed approach in the evaluation of target engagement and NCE selection.ConclusionsWith the rather easily-performed combinatory mapping approach, it was possible to provide quantitative information supporting the decision making in the drug discovery setting.
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  • Resultat 1-7 av 7

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