| 61. |
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| 62. |
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| 63. |
- Okroj, Marcin, et al.
(författare)
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Characterization of the complement inhibitory function of Rhesus rhadinovirus complement control protein (RCP).
- 2009
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 2008:Nov 6., s. 505-514
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Tidskriftsartikel (refereegranskat)abstract
- Rhesus Rhadinovirus (RRV) is currently the closest known, fully sequenced homolog of human Kaposi's sarcoma-associated herpesvirus (KSHV). Both these viruses encode complement inhibitors: KSHV-complement control protein (KCP) and RRV-complement control protein (RCP). Previously we characterized in detail the functional properties of KCP as complement inhibitor. Herein, we performed comparative analyses for two variants of RCP protein, encoded by RRV strains H26-95 and 17577. Both RCP variants and KCP inhibited human and rhesus complement when tested in hemolytic assays measuring all steps of activation via the classical and the alternative pathway. RCP variants from both RRV strains supported C3b- and C4b-degradation by factor I and decay-acceleration of the classical C3 convertase, similar to KCP. Additionally, the 17577 RCP variant accelerated decay of the alternative C3 convertase, which was not seen for KCP. In contrast to KCP, RCP showed no affinity to heparin and is the first described complement inhibitor in which the binding site for C3b/C4b does not interact with heparin. Molecular modeling shows a structural disruption in the region of RCP that corresponds to the KCP-heparin binding site. This makes RRV a superior model for future in vivo investigations of complement evasion, as RCP does not play a supportive role in viral attachment as KCP does.
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| 64. |
- Orrenius, Ulf E, et al.
(författare)
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Ergonomic evaluation of a new type of rollator
- 2007
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Konferensbidrag (refereegranskat)abstract
- A prototype of a novel rollator, named “Walker” on the Swedish market,was evaluated with respect to obstacle climbing, steering and generalusability. The prototype has a novel design with a triangular base and adouble front wheel on a lever arm arrangement to simplify passing acrossobstacles. Both technical tests and user tests were carried out.The main conclusion is that “Walker” is in several respectsergonomically advantageous compared to the traditional out-door rollators,especially in rough terrain and when passing obstacles. Suggestions forimprovements of certain functions of “Walker” are made, such as handlingin narrow environments and the ability to fold the rollator.
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| 65. |
- Osvalder, Anna-Lisa, et al.
(författare)
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Methods
- 2009. - 1:1
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Ingår i: Work and technology on human terms. - Stockholm : Prevent. - 9789173650588 ; , s. 463-566
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Bokkapitel (populärvet., debatt m.m.)
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| 66. |
- Osvalder, Anna-Lisa, et al.
(författare)
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Metoder
- 2008. - 1:1
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Ingår i: Arbete och teknik på människans villkor. - Stockholm : Prevent. - 9789173650373 ; , s. 463-566
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Bokkapitel (populärvet., debatt m.m.)
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| 67. |
- Osvalder, Anna-Lisa, 1961, et al.
(författare)
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Metoder
- 2008
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Ingår i: Arbete och teknik på människans villkor. - 9789173650373 ; , s. 105-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 68. |
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| 69. |
- Pattaro, Cristian, et al.
(författare)
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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| 70. |
- Rodrigues Coutinho, Brenda, et al.
(författare)
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Meeting the Challenges of Home Care in Small Residential Bathrooms : Creation of the Bathroom Aid Inventory
- 2022
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Ingår i: Conference Proceedings of the 51<sup>st</sup> NES Conference. ; , s. 176-177
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Konferensbidrag (refereegranskat)abstract
- Background and purposeOur society is facing major demographic challenges in healthcare. The growing population of older people is outpacing the creation of residential care facilities like nursing homes, meaning that more and more people are ‘aging in place’. ‘Aging in place’ means continuing to reside in a private residence in the community even as care needs intensify. It is an economically efficient option and often preferred by aging people, but it also brings substantial challenges. Eventually people require support from home careworkers with the vital and personal tasks that take place in the bathroom: toileting and bathing. However, residential bathrooms are often small and not designed to accommodate a care recipient, care worker, and mobility aids such as a walker or wheelchair. There is a growing need to update residential bathrooms to meet the evolving needs of older residents. Although there exist several aids and assistive devices intended to facilitate bathroom tasks, this can be hard for users and caregivers to navigate. This project was undertaken as part of a larger study funded by AFA Försäkring. The goal of this portion was to develop an inventory of currently-available bathroom assistance devices for use by residents and their family members, health care organizations, insurance agencies, and other stakeholders. The primary research question was: What type of bathroom assistive devices are currently available, either commercially or in prototype form, intended to assist users with the tasks of toileting, bathing, and handwashing?MethodologyThe primary method was web search and document review across several domains: regulations, assistive devices, and residential bathroom renovation examples. The first set of searches investigated the legislation and guidelines on bathroom design both for residential and healthcare settings; consistent and conflicting specifications were noted. The second set of searches was for assistive devices that could be used to facilitate bathing and toileting tasks in residential bathrooms. Examples of renovated residential bathrooms were solicited through authors’ networks.ResultsWhen it came to guidelines and specifications for bathroom design, there was substantial tension between the regulations set out by the Swedish Work Environment Authority and the National Board of Housing, Building and Planning. The inventory includes images of assistive devices as well as their main features: target task (bathing, toileting, personal care, handwashing), dimensions, weight ratings, colors, materials, store, website address, accessibility, and price. Documented assistive device categories include shower benches, toilet aids, support handles, showers, washbasins, taps, alarm buttons, contrast marks, and others, with approximately 20 examples for each.ConclusionsThis project developed an inventory of currently-available bathroom assistance devices, intended to inform users’ selection of devices for growing care needs in realistic (i.e. nonideal) settings. However, it is not the intention for the inventory represent an assessmentof the quality, safety, effectiveness, or usability of the devices. While it is hoped this list will represent the variety of available devices, it is also not intended to be exhaustive. Together with an introduction that includes the examples of renovated bathrooms, the inventory will be disseminated as a searchable web-based resource.
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