| 41. |
- Beni, Valerio, 1972-, et al.
(författare)
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Printed electrochemical instruments for biosensors
- 2015
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Ingår i: ECS Transactions. - : The Electrochemical Society. - 9781607685395 ; , s. 1-13
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Konferensbidrag (refereegranskat)abstract
- Mobile diagnostics for healthcare, food safety and environmental monitoring, demand a new generation of inexpensive sensing systems suitable for production in high volume. Herein we report on the development of a new disposable electrochemical instrument exploiting the latest advances in printed electronics and printed biosensors. The current system is manufactured under ambient conditions with all interconnections printed; electrochemical measurements and data elaboration are realized by the integration onto the platform of two chips: a MICROCHIP-PIC24F16KA101 and a Texas Instrument's LMP91000. A PEDOT.PSS vertical electrochromic display (VECD) is also incorporated into the system to visualize the data. A printed Enfucell 3V manganese dioxide battery was used to deliver the required power. Finally, in order to demonstrate the utility of the system, screen-printed sensors for the detection of glucose were added and the performance of the overall system was evaluated.
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| 42. |
- Berglund, Christer, et al.
(författare)
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A note on inter-country differences in waste paper recovery and utilization
- 2002
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Ingår i: Resources, Conservation and Recycling. - 0921-3449 .- 1879-0658. ; 34:3, s. 175-191
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Tidskriftsartikel (refereegranskat)abstract
- Countries worldwide express waste paper recycling targets in terms of recovery and utilization rates. The main purpose of this paper is to identify and analyze the most important determinants of inter-country differences in these waste paper rates. By employing two regression models and using data for 89 and 81 countries, respectively, the paper concludes that relative waste paper recovery and use are largely market-determined, and depend thus on long-standing economic factors such as population intensity and competitiveness in the world market for paper and board products. We also find evidence that supports the conjecture that rich countries tend to recover relatively more waste paper than is the case in low-income countries, reflecting the higher demand for waste management and environmental policies in more developed economies. As recovery and utilization rates are determined largely by long-standing economic and demographic characteristics the degree of policy flexibility in affecting these rates may be limited. In particular, an ambitious utilization rate target may be very costly to enforce as it can conflict with existing trade patterns of paper and board products as well as with other environmental goals. Additional policy targets may, therefore, be desirable, especially since paper recycling is motivated primarily by environmental concerns and seldom is a benign activity in itself.
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| 43. |
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| 44. |
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| 45. |
- Bivik, Caroline, et al.
(författare)
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Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells
- 2015
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Ingår i: Genetics. - : Genetics Society of America. - 0016-6731 .- 1943-2631. ; 200:4, s. 1229-1244
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Tidskriftsartikel (refereegranskat)abstract
- The expression of neuropeptides is often extremely restricted in the nervous system, making them powerful markers for addressing cell specification . In the developing Drosophila ventral nerve cord, only six cells, the Ap4 neurons, of some 10,000 neurons, express the neuropeptide FMRFamide (FMRFa). Each Ap4/FMRFa neuron is the last-born cell generated by an identifiable and well-studied progenitor cell, neuroblast 5-6 (NB5-6T). The restricted expression of FMRFa and the wealth of information regarding its gene regulation and Ap4 neuron specification makes FMRFa a valuable readout for addressing many aspects of neural development, i.e., spatial and temporal patterning cues, cell cycle control, cell specification, axon transport, and retrograde signaling. To this end, we have conducted a forward genetic screen utilizing an Ap4-specific FMRFa-eGFP transgenic reporter as our readout. A total of 9781 EMS-mutated chromosomes were screened for perturbations in FMRFa-eGFP expression, and 611 mutants were identified. Seventy-nine of the strongest mutants were mapped down to the affected gene by deficiency mapping or whole-genome sequencing. We isolated novel alleles for previously known FMRFa regulators, confirming the validity of the screen. In addition, we identified novel essential genes, including several with previously undefined functions in neural development. Our identification of genes affecting most major steps required for successful terminal differentiation of Ap4 neurons provides a comprehensive view of the genetic flow controlling the generation of highly unique neuronal cell types in the developing nervous system.
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| 46. |
- Blicharska, Malgorzata, 1979-, et al.
(författare)
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Biodiversity’s contributions to sustainable development
- 2019
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Ingår i: Nature Sustainability. - : Nature Publishing Group. - 2398-9629. ; 2, s. 1083-1093
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Forskningsöversikt (refereegranskat)abstract
- International concern to develop sustainably challenges us to act upon the inherent links between our economy, society and environment, and is leading to increasing acknowledgement of biodiversity's importance. This Review discusses the breadth of ways in which biodiversity can support sustainable development. It uses the Sustainable Development Goals (SDGs) as a basis for exploring scientific evidence of the benefits delivered by biodiversity. It focuses on papers that provide examples of how biodiversity components (that is, ecosystems, species and genes) directly deliver benefits that may contribute to the achievement of individual SDGs. It also considers how biodiversity's direct contributions to fulfilling some SDGs may indirectly support the achievement of other SDGs to which biodiversity does not contribute directly. How the attributes (for example, diversity, abundance or composition) of biodiversity components influence the benefits delivered is also presented, where described by the papers reviewed. While acknowledging potential negative impacts and trade-offs between different benefits, the study concludes that biodiversity may contribute to fulfilment of all SDGs.
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| 47. |
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| 48. |
- Borgegard, Tomas, et al.
(författare)
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Alzheimers Disease: Presenilin 2-Sparing gamma-Secretase Inhibition Is a Tolerable A beta Peptide-Lowering Strategy
- 2012
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Ingår i: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
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Tidskriftsartikel (refereegranskat)abstract
- gamma-Secretase inhibition represents a major therapeutic strategy for lowering amyloid beta (A beta) peptide production in Alzheimers disease (AD). Progress toward clinical use of gamma-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The gamma-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between A beta production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1(PS1) over PS2 subclass of gamma-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain A beta levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious gamma-secretase targeting strategy for AD.
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| 49. |
- Borgegård, Tomas, et al.
(författare)
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Alzheimer's Disease : Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
- 2012
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Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
-
Tidskriftsartikel (refereegranskat)abstract
- γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward clinical use of γ-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The γ-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between Aβ production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1 (PS1) over PS2 subclass of γ-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain Aβ levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious γ-secretase targeting strategy for AD.
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| 50. |
- Bothén, Simon, et al.
(författare)
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An analysis and comparative user study on interactions in mobile virtual reality games
- 2018
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Ingår i: FDG '18: Proceedings of the 13th International Conference on the Foundations of Digital Games. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450365710
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Konferensbidrag (refereegranskat)abstract
- Mobile Virtual Reality (MVR) makes Virtual Reality games more accessible to a broader audience. Interaction design guidelines and best practices for MVR experiences are available for developers. In this paper, we specifically explore interactions in MVR games, a particular subset of MVR experiences that is becoming popular. A set of MVR games is analyzed with a special focus on head gaze, categorizing and isolating their mechanics implemented with this common MVR technique. This analysis is the basis of a test application in the MVR interactions are implemented and later compared to a traditional game pad controller in three different challenges. A comparative user study has been carried out from the perspective of both gamers and non-gamers facing these challenges. Results show the preferences and performances of the players using all the interactions, highlighting an interesting generalized preference for MVR interactions over the traditional controller in some of the analyzed cases.
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