| 41. |
- Abdalla, Mohammed Altigani, et al.
(författare)
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Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome : a systematic review and meta-analysis of randomised controlled trials
- 2022
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Ingår i: Archives of Gynecology and Obstetrics. - : Springer. - 0932-0067 .- 1432-0711.
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Forskningsöversikt (refereegranskat)abstract
- Context: Polycystic ovary syndrome (PCOS) is a complex endocrine disease that affects women of reproductive age and is characterised by biochemical and clinical androgen excess.Aim: To evaluate the efficacy of pharmacological interventions used to decrease androgen hormones in women with PCOS.Data source: We searched PubMed, MEDLINE, Scopus, Embase, Cochrane library and the Web of Science from inception up to March 2021. Data synthesis Two reviewers selected eligible studies and extracted data, and the review is reported according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).Results: Of the 814 randomised clinical trials (RCTs) located in the search, 92 met the eligibility criteria. There were significant reductions in total testosterone level with metformin versus (vs) placebo (SMD: - 0.33; 95% CI - 0.49 to - 0.17, p < 0.0001, moderate grade evidence) and dexamethasone vs placebo (MD:-0.86 nmol/L; 95% CI - 1.34 to - 0.39, p = 0.0004, very low-grade evidence). Significant reductions in the free testosterone with sitagliptin vs placebo (SMD: - 0.47; 95% CI - 0.97 to 0.04, p = 0.07, very low-grade evidence), in dehydroepiandrosterone sulphate (DHEAS) with flutamide vs finasteride (MD: - 0.37 mu g/dL; 95% CI - 0.05 to - 0.58, p = 0.02, very low-grade evidence), a significant reduction in androstenedione (A4) with rosiglitazone vs placebo (SMD: - 1.67; 95% CI - 2.27 to - 1.06; 59 participants, p < 0.00001, very low-grade evidence), and a significant increase in sex hormone-binding globulin (SHBG) with oral contraceptive pill (OCP) (35 mu g Ethinyl Estradiol (EE)/2 mg cyproterone acetate (CPA)) vs placebo (MD: 103.30 nmol/L; 95% CI 55.54-151.05, p < 0.0001, very low-grade evidence) were observed.Conclusion: Metformin, OCP, dexamethasone, flutamide, and rosiglitazone use were associated with a significant reduction in biochemical hyperandrogenemia in women with PCOS, though their individual use may be limited due to their side effects.PROSPERO registration No CRD42020178783.
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| 42. |
- Abdalla, Mohammed A., et al.
(författare)
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Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome : A systematic review and meta-analysis of randomized controlled trials
- 2022
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Ingår i: Clinical Endocrinology. - : John Wiley & Sons. - 0300-0664 .- 1365-2265. ; 96:3, s. 371-394
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Forskningsöversikt (refereegranskat)abstract
- Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterized by insulin resistance and is a major risk factor for type 2 diabetes mellitus (T2DM). The objective was to review the literature on the effect of different pharmacological interventions on insulin resistance in women with PCOS.Design: We searched PubMed, MEDLINE, Scopus, Embase, Cochrane library and the Web of Science in April 2020 and updated in March 2021. The study follows the 2020 Preferred Reporting Items for Systematic reviews and Meta-ana. Reviwers extracted data and assessed the risk of bias using the Cochrane risk of bias tool.Results: In 58 randomized controlled trials there were significant reductions in the fasting blood glucose (FBG) with metformin versus placebo (standardized mean difference [SMD]: -0.23; 95% confidence interval [CI]: -0.40, -0.06; I-2 = 0%, low-grade evidence), and acarbose versus metformin (mean difference [MD]: -10.50 mg/dl; 95% CI: -15.76, -5.24; I-2 = 0%, low-grade evidence). Significant reductions in fasting insulin (FI) with pioglitazone versus placebo (SMD: -0.55; 95% CI: -1.03, -0.07; I-2 = 37%; p = .02, very-low-grade evidence). A significant reduction in homoeostatic model assessment of insulin resistance (HOMA-IR) was seen with exenatide versus metformin (MD: -0.34; 95% CI: -0.65, -0.03; I-2 = 0%, low-grade evidence). No effect on homoeostatic model assessment of beta cells (HOMA-B) was observed.Conclusions: Pharmacological interventions, including metformin, acarbose, pioglitazone and exenatide have significant effects on FBG, FI, HOMA-IR but not on HOMA-B.
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| 43. |
- Abdekhodaie, Ehsan, et al.
(författare)
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WordCommentsAnalyzer : A windows software tool for qualitative research
- 2018
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Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- There is a lack of free software that provides a professional and smooth experience in text editing and markup for qualitative data analysis. Word processing software like Microsoft Word provides a good editing experience, allowing the researcher to effortlessly add comments to text portions. However, organizing the keywords and categories in the comments can become a more difficult task when the amount of data increases. We present WordCommentsAnalyzer, a software tool that is written in C# using .NET Framework and OpenXml, which helps a qualitative researcher to organize codes when using Microsoft Word as the primary text markup software. WordCommentsAnalyzer provides an effective user interface to count codes, to organize codes in a code hierarchy, and to see various data extracts belonging to each code. It also offers basic visualization tools. We illustrate how to use this software by conducting a preliminary content analysis on Tweets with the #successfulaging hashtag. We also demonstrate that the software has satisfactory performance on a large dataset of Iranian journals abstracts. We hope this open-source software will facilitate qualitative data analysis by researchers who are interested in using Word for this purpose.
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| 44. |
- Abdeldaim, Guma M. K., et al.
(författare)
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Quantitative fucK gene polymerase chain reaction on sputum and nasopharyngeal secretions to detect Haemophilus influenzae pneumonia
- 2013
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Ingår i: Diagnostic microbiology and infectious disease. - : Elsevier. - 0732-8893 .- 1879-0070. ; 76:2, s. 141-146
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Tidskriftsartikel (refereegranskat)abstract
- A quantitative polymerase chain reaction (PCR) for the fucK gene was developed for specific detection of Haemophilus influenzae. The method was tested on sputum and nasopharyngeal aspirate (NPA) from 78 patients with community-acquired pneumonia (CAP). With a reference standard of sputum culture and/or serology against the patient's own nasopharyngeal isolate, H. influenzae etiology was detected in 20 patients. Compared with the reference standard, fucK PCR (using the detection limit 10(5) DNA copies/mL) on sputum and NPA showed a sensitivity of 95.0% (19/20) in both cases, and specificities of 87.9% (51/58) and 89.5% (52/58), respectively. In a receiver operating characteristic curve analysis, sputum fucK PCR was found to be significantly superior to sputum P6 PCR for detection of H. influenzae CAP. NPA fucK PCR was positive in 3 of 54 adult controls without respiratory symptoms. In conclusion, quantitative fucK real-time PCR provides a sensitive and specific identification of H. influenzae in respiratory secretions.
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| 45. |
- Abdelnour, Samer, et al.
(författare)
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Agency and Instituions in Organization Studies
- 2017
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Ingår i: Organization Studies. - London : Sage Publications. - 0170-8406 .- 1741-3044. ; 38:12, s. 1775-1792
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Tidskriftsartikel (refereegranskat)abstract
- Agency and institutions are essential concepts within institutional theory. In this Perspectives issue, we draw on a select group of Organization Studies articles to provide an overview of the topic of agency and institutions. We first consider different ways of defining agency and institutions and examine their implications for institutional theory. We then analyse the relationship of actors and institutions through four lenses – the wilful actor, collective intentionality, patchwork institutions and modular individuals. Our analysis leads us to dissociate agency from individuals and view it as a capacity or quality that stems from resources, rights and obligations tied to the roles and social positions actors occupy. Roles and social positions are institutionally engineered. It is social actors qua occupants of roles and positions (not individuals) that enter the social ‘stage’ and exercise agency.
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| 46. |
- Abdelrahman, Islam, 1982-, et al.
(författare)
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Pros and Cons of Early and Late Skin Grafting in Children with Burns : Evaluation of Common Concepts
- 2022
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Ingår i: European Burn Journal. - : MDPI. - 2673-1991. ; 3:1, s. 180-187
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is no consensus regarding the timing of surgery in children with smaller burn size, specifically in deep dermal burns. Delayed surgery has risks in terms of infection and delayed wound healing. Early surgery also risks the removal of potentially viable tissue. Our aim was to investigate the effect of the timing of surgical intervention on the size of the area operated on and the time to wound healing. Methods: A retrospective analysis for all children (<18 years) with burn size <20% body surface area (BSA%) during 2009–2020 who were operated on with a split-thickness skin graft. The patients were grouped by the timing of the first skin graft operation: early = operated on within 14 days of injury; delayed = operated on more than two weeks after injury. Results: A total of 84 patients were included in the study, 43 who had an early operation and 41 who had a delayed operation. There were no differences between the groups regarding burn size, or whether the burns were superficial or deep. The mean duration of healing time was seven days longer in the group with delayed operation (p = 0.001). The area operated on was somewhat larger (not significantly so) in the group who had early operation. Nine children had two skin graft operations, eight in the early group and one in the delayed group (p = 0.03). Conclusion: The patients who were operated on early had the advantage of a shorter healing time, but there was a higher rate of complementary operations and a tendency towards a larger burn excision.
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| 47. |
- Abdelzadeh, Ali, 1981-, et al.
(författare)
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Bilaga 2: En utvärdering av Skolval 2010
- 2015
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Ingår i: Öva och ta ställning. - : Myndigheten för ungdoms- och civilsamhällesfrågor. ; , s. 47-55
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Bokkapitel (populärvet., debatt m.m.)abstract
- Syftet med denna rapport är att: (a) redogöra för vilka elever som deltog i skolvalet 2010, (b) samt undersöka huruvida deltagandet i skolvalet har någon effekt på ungas intresse för politik/samhällsfrågor, politiska diskussioner med föräldrar och vänner, intention att rösta i framtida val samt politiskt deltagande. För denna undersökning används först och främst enkätdata från Political socialization Project (PSP); en pågående longitudinell studie som undersöker framväxten av unga människors politiska attityder och engagemang (Amnå, Ekström, Kerr & Stattin, 2009). Analyserna i denna rapport omfattar endast elever i PSP-studien vars skola anmält till Myndigheten för ungdoms- och civilsamhällesfrågor att de genomfört skolval. Totalt omfattar de analyser som denna rapport baseras på 3 högstadieskolor och 3 gymnasieskolor vilket sammantaget blir 860 elever.
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| 48. |
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| 49. |
- Abdelzadeh, Ali, 1981-, et al.
(författare)
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Dissatisfied Citizens : An Asset to or a Liability on the Democratic Functioning of Society?
- 2015
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Ingår i: Scandinavian Political Studies. - : Wiley-Blackwell. - 0080-6757 .- 1467-9477. ; 38:4, s. 410-436
-
Tidskriftsartikel (refereegranskat)abstract
- Past research has shown that, although a majority of citizens in democracies support the idea of democracy as a form of governance, some tend to be distrustful of democratic institutions and express dissatisfaction with the way democracy works. It is argued in this article that to better understand the role of various groups of dissatisfied citizens in the democratic functioning of a society, one should examine their democratic characteristics. Based on youth's dissatisfaction with the performance of political institutions and the principles of democracy, four distinct groups of citizens are identified. These groups are then compared in terms of their political engagement, knowledge and interest, values and attitudes, and disposition to break the law. The results showed that youths with high levels of principle- and performance-driven dissatisfaction were less likely to participate in politics, less knowledgeable and interested in political issues, and more likely to break the law, even if people got hurt compared with other groups. In contrast, youths who were only dissatisfied with the performance of democratic institutions were more likely to participate in politics, and had higher tolerance towards immigrants, and political interest and knowledge. They were also more likely, peacefully and without harming other people, to break the law to change society. Overall, by examining distinct groups of dissatisfied citizens and their democratic characteristics, this study contributes to the general debate on the role of dissatisfied citizens in democracies.
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| 50. |
- Abdelzadeh, Ali, 1981-, et al.
(författare)
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Dissatisfied citizens : an asset or a burden in democratic functioning of a society?
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Past research has shown that, whereas the majority of people in democracies support the idea of democracy as a form of governance, some citizens are dissatisfied with the democratic institutions and the way democracy performs. In this paper, we examined democratic characteristics of dissatisfied youths to understand the role they play in the democratic functioning of a society. Based on youth’s dissatisfaction with the performance of political institutions and the principles of democracy, we identified four groups distinct of citizens. Then, we compared these groups in terms of their political engagement, knowledge and interest, values and attitudes, and law breaking attitudes. The results showed that youths with high levels of principle- and performance-driven dissatisfaction were less likely to participate in politics, less knowledgeable and interested in political issues, and more likely to break the laws, even if people got hurt compared to other three groups. In contrast, youths who were only dissatisfied with the performance of democratic institutions were more likely to participate in politics, and have higher humanistic values and tolerance towards immigrants. By examining distinct groups of dissatisfied citizens and their democratic characteristics, the current study contributes to the general debate on the role of dissatisfied citizens in democracies.
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