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- Canbäck, Björn, 1961-
(författare)
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In silico Studies of Early Eukaryotic Evolution
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A question of great interest in evolutionary biology is how and why the eukaryotic cell evolved. Several hypotheses have been proposed, ranging from an early emergence of a primitive eukaryotic cell, to various fusion models like the hydrogen hypothesis. Within this context, relevant bacterial gene families and genomes are examined in this thesis.The mitochondrion, the energy producing organelle in the eukaryotic cell, is generally believed to be of α-proteobacterial descent. To learn more about mitochondrial evolution, and therefore eukaryotic evolution, the genomes of the α-proteobacteria Bartonella henselae and Bartonella quintana were sequenced. Software was developed and used in the annotation of these genomes.Several gene products of nuclear-encoded genes are exported to the mitochondrion. Many of these genes are thought to originate from the emerging organelle. An analysis of the more than 400 genes encoding proteins targeted to the yeast mitochondrion indicates that one set of genes originated from the bacterial symbiont, while the eukaryotic host contributed another. Thus, the mitochondrial proteome has a dual origin.The hydrogen hypothesis postulates that the glycolytic genes belong to the group of genes that were transferred from symbiont to host. These genes are thoroughly analysed from a phylogenetic perspective. Contrary to the predictions of the hydrogen hypothesis, the results provide no support for a close relationship between nuclear genes encoding glycolytic enzymes and their α-proteobacterial homologs. In general, it is thought that intensive gene transfers may limit our ability to reconstruct gene and species evolution, especially among microbes. A phylogenetic analysis of a large cohort of genes from the AT-rich genome of the γ-proteobacterium Buchnera aphidicola (Sg) resulted in a high fraction of atypical tree topologies, previously interpreted as horizontal gene transfers. By applying methods that accommodate for asymmetric nucleotide substitutions, it is shown that many well-supported gene topologies are drastically altered, so that they now agree with the rRNA topology. The conclusion is that atypical topologies may not necessarily be evidence for horizontal gene transfers.
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- Chen, W, et al.
(författare)
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The origin of x-ray luminescence from CdTe nanoparticles in CdTe/BaFBr : Eu2+ nanocomposite phosphors
- 2006
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Ingår i: Applied Physics Reviews. - : AIP Publishing. - 1931-9401. ; 99:3
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Tidskriftsartikel (refereegranskat)abstract
- X-ray luminescence from CdTe nanoparticles is observed when CdTe nanoparticles are encapsulated into BaFBr:Eu2+ phosphors. In contrast, negligible x-ray luminescence is observed from the unencapsulated nanoparticles, either in solution or in solid form. The origin of the x-ray luminescence is attributed to the effective energy transfer from Eu2+ ions to CdTe nanoparticles in the nanocomposite materials. The x-ray luminescence of these nanocomposites is dose dependent and the emission wavelength is size adjustable which may allow use as a type of dosimeter for both in vitro and in vivo applications. (c) 2006 American Institute of Physics.
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- Chen, Xiulai, et al.
(författare)
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DCEO Biotechnology: Tools to Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals
- 2018
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Ingår i: Chemical Reviews. - : American Chemical Society (ACS). - 0009-2665 .- 1520-6890. ; 118:1, s. 4-72
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Forskningsöversikt (refereegranskat)abstract
- Chemical synthesis is a well established route for producing many chemicals on a large scale, but some drawbacks still exist in this process, such as unstable intermediates, multistep reactions, complex process control, etc. Biobased production provides an attractive alternative to these challenges, but how to make cells into efficient factories is challenging. As a key enabling technology to develop efficient cell factories, design-construction-evaluation-optimization (DCEO) biotechnology, which incorporates the concepts and techniques of pathway design, pathway construction, pathway evaluation, and pathway optimization at the systems level, offers a conceptual and technological framework to exploit potential pathways, modify existing pathways and create new pathways for the optimal production of desired chemicals. Here, we summarize recent progress of DCEO biotechnology and examples of its application, and provide insights as to when, what and how different strategies should be taken. In addition, we highlight future perspectives of DCEO biotechnology for the successful establishment of biorefineries.
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- Chen, Xi, et al.
(författare)
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Device noise reduction for Silicon nanowire field-effect-transistor based sensors by using a Schottky junction gate
- 2019
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Ingår i: ACS Sensors. - : American Chemical Society (ACS). - 2379-3694. ; 4:2, s. 427-433
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Tidskriftsartikel (refereegranskat)abstract
- The sensitivity of metal-oxide-semiconductor field-effect transistor (MOSFET) based nanoscale sensors is ultimately limited by noise induced by carrier trapping/detrapping processes at the gate oxide/semiconductor interfaces. We have designed a Schottky junction gated silicon nanowire field-effect transistor (SiNW-SJGFET) sensor, where the Schottky junction replaces the noisy oxide/semiconductor interface. Our sensor exhibits significantly reduced noise, 2.1×10-9 V2µm2/Hz at 1 Hz, compared to reference devices with the oxide/semiconductor interface operated at both inversion and depletion modes. Further improvement can be anticipated by wrapping the nanowire by such a Schottky junction thereby eliminating all oxide/semiconductor interfaces. Hence, a combination of the low-noise SiNW-SJGFET sensor device with a sensing surface of the Nernstian response limit holds promises for future high signal-to-noise ratio sensor applications.
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- Chen, Xiaowen, et al.
(författare)
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Multi-FPGA Implementation of a Network-on-Chip Based Many-core Architecture with Fast Barrier Synchronization Mechanism
- 2010
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Ingår i: Proceedings of the IEEE Norchip Conference. - 9781424489732
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Konferensbidrag (refereegranskat)abstract
- In this paper, we propose a fast barrier synchronization mechanism, targetingNetwork-on-Chip based manycore architectures. Its salient feature is that, once thebarrier condition is reached, the "barrier release" acknowledgement is routed to all processor nodes in a broadcast way in order to save area by avoiding storing source node information and to minimize completion time by eliminating serialization of barrierreleasing. Then, we construct a multi-FPGA platform using Xilinx® Virtex 5 as FPGA chipsand implement a NoC based many-core architecture on it. FPGA utilization and simulation results show that our mechanism demonstrates both area and performance advantages over the barrier synchronization counterpart with unicast barrier releasing.
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