| 61. |
- Carlsson, Anna, et al.
(författare)
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Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1
- 2002
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Ingår i: Neurology. - : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 59:11, s. 1804-1807
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Tidskriftsartikel (refereegranskat)abstract
- Migraine is the most common type of chronic episodic headache. To find novel susceptibility genes for familial migraine with and without aura, a genomewide screen was performed in a large family from northern Sweden. Evidence of linkage was obtained on chromosome 6p12.2-p21.1, with a maximum two-point lod score of 5.41 for marker D6S452. The patients with migraine shared a common haplotype of 10 Mb between markers D6S1650 and D6S1960.
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| 62. |
- Chirica, Laura C., et al.
(författare)
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Expression and localization of α- and β-carbonic anhydrase in Helicobacter pylori
- 2002
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Ingår i: Biochimica et Biophysica Acta - Proteins and Proteomics. - 1570-9639 .- 1878-1454. ; 1601:2, s. 192-199
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Tidskriftsartikel (refereegranskat)abstract
- Helicobacter pylori, the causative agent of peptic ulcer disease, expresses two different forms of the zinc-containing enzyme carbonic anhydrase (CA) (α and β), catalyzing the reversible hydration of CO2. Presumably, the high CO2 requirement of H. pylori implies an important role for this enzyme in the bacterial physiology. In this paper, expression of the CAs has been analyzed in three different strains of the bacterium, 26695, J99 and 17.1, and appears to be independent of CO2 concentration in the investigated range (0.1–10%). Presence of the potent and highly specific CA inhibitor, acetazolamide, in the medium does not seem to inhibit bacterial growth at the given sulfonamide concentration. Moreover, the localization and distribution of the α-CA was analyzed by immunonegative staining, while SDS-digested freeze-fracture immunogold labelling was used for the β-form of the enzyme. The latter method has the advantage of allowing assessment of protein localization to distinct cell compartments and membrane structures. The resulting electron microscopy images indicate a localization of the β-CA in the cytosol, on the cytosolic side of the inner membrane and on the outer membrane facing the periplasmic space. The α-enzyme was found attached to the surface of the bacterium.
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| 63. |
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| 64. |
- Domkin, Dmitry, et al.
(författare)
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Structure of joint variability in bimanual pointing tasks
- 2002
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Ingår i: Experimental Brain Research. - : Springer Science and Business Media LLC. - 0014-4819 .- 1432-1106. ; 143, s. 11-23
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Tidskriftsartikel (refereegranskat)abstract
- Changes in the structure of motor variability during practicing a bimanual pointing task were investigated using the framework of the uncontrolled manifold (UCM) hypothesis. The subjects performed fast and accurate planar movements with both arms, one moving the pointer and the other moving the target. The UCM hypothesis predicts that joint kinematic variability will be structured to selectively stabilize important task variables. This prediction was tested with respect to selective stabilization of the trajectory of the endpoint of each arm (unimanual control hypotheses) and with respect to selective stabilization of the timecourse of the vectorial distance between the target and the pointer tip (bimanual control hypothesis). Components of joint position variance not affecting and affecting a mean value of a selected variable were computed at each 10% of normalized movement time. The ratio of these two components ( R(V)) served as a quantitative index of selective stabilization. Both unimanual control hypotheses and the bimanual control hypothesis were supported both prior to and after practice. However, the R(V) values for the bimanual control hypothesis were significantly higher than for either of the unimanual control hypothesis, suggesting that the bimanual synergy was not simply a simultaneous execution of two unimanual synergies. After practice, an improvement in both movement speed and accuracy was accompanied by counterintuitive changes in the structure of kinematic variability. Components of joint position variance affecting and not affecting a mean value of a selected variable decreased, but there was a significantly larger drop in the latter when applied on each of the three selected task variables corresponding to the three control hypotheses. We conclude that the UCM hypothesis allows quantitative assessment of the degree of stabilization of selected performance variables and provides information on changes in the structure of a multijoint synergy that may not be reflected in its overall performance.
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| 65. |
- Druzin, Michael, et al.
(författare)
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Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.
- 2002
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Ingår i: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 542:Pt 1, s. 131-46
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Tidskriftsartikel (refereegranskat)abstract
- Calcium influx into the presynaptic nerve terminal is well established as a trigger signal for transmitter release by exocytosis. By studying dissociated preoptic neurons with functional adhering nerve terminals, we here show that presynaptic Ca2+ influx plays dual and opposing roles in the control of spontaneous transmitter release. Thus, application of various Ca2+ channel blockers paradoxically increased the frequency of spontaneous (miniature) inhibitory GABA-mediated postsynaptic currents (mIPSCs). Similar effects on mIPSC frequency were recorded upon washout of Cd2+ or EGTA from the external solution. The results are explained by a model with parallel Ca2+ influx through channels coupled to the exocytotic machinery and through channels coupled to Ca2+-activated K+ channels at a distance from the release site.
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| 66. |
- Elenius, Lars, 1952-
(författare)
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A place in the memory of nation : minority policy towards the Finnish speakers in Sweden and Norway
- 2002
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Ingår i: Acta Borealia. - : Informa UK Limited. - 0800-3831 .- 1503-111X. ; 19:2, s. 103-123
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Tidskriftsartikel (refereegranskat)abstract
- This article is devoted to an analysis of language policy towards the Finnish-speaking minorities in Sweden and Norway from the end of the nineteenth century until ca. 1940. After the 1880s, the language policy in both countries turned into a nationalistic phase. The common underlying doctrine was to transmit the majority language and culture to the minorities, in order to make them melt into an imagined homogeneous national culture. The minority policy was relatively similar in character in the two countries up to the end of the First World War. After that time it started to diverge. While Norway continued with an assimilative policy without compromises, Sweden adopted a somewhat modified policy. This altered policy in Sweden was partly due to the long continuity and minority status of the Sami and Torne Valley people in the Swedish nation state, but also to elements of modernization and international political change.
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| 67. |
- Espvall, Majen, et al.
(författare)
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Social networks of women with undefined musculoskeletal disorder
- 2002
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Ingår i: Social Work in Health Care. - : Taylor & Francis. - 0098-1389 .- 1541-034X. ; 36:1, s. 77-91
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Tidskriftsartikel (refereegranskat)abstract
- This study was conducted to investigate social integration among, and the availability of social support for, female patients with undefined musculoskeletal disorder compared to women with coronary heart disease. The aim was to elucidate the importance of a clear diagnosis for the social network relationships of these female patients. For the measurement of social support two instruments were used: an abbreviated version of the Interview Schedule for Social Interaction and a condensed version of the Interpersonal Support Evaluation List. After adjustment for age, marital and employment status, significant differences can be recognized between the two groups of patients: MSD-patients interact with fewer people and receive less emotional support. Implications for social work practice and issues for future research are presented.
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| 68. |
- Evertsson, H., et al.
(författare)
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NMR self diffusion measurements of the monooleoylglycerol/poly ethylene glycol/water L-3 phase
- 2002
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Ingår i: Colloids and Surfaces B. - 0927-7765 .- 1873-4367. ; 26:02-jan, s. 21-29
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Tidskriftsartikel (refereegranskat)abstract
- The monooleoylglycerol (GMO)/poly ethylene oxide (PEG)/water sponge (L-3) phase has been investigated by pulsed-gradient spin-echo NMR self-diffusion. The data allow the L-3 phase to be modeled as a bicontinuous system with respect to the lipid and water domains. It is proposed by using the interconnected rod model that the solvent PEG mainly distributes to the water domain, but has a higher weight fraction partition to the lipid head groups of the local GMO bilayer than water. The data is put in relation to earlier self-diffusion measurements on the binary GMO/water cubic phase, as well as earlier conductivity and X-ray diffraction measurements on the very same L-3 phase.
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| 69. |
- Fröjse, Rolf, et al.
(författare)
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Intestinal pHi studied with continuous saline tonometry during ischaemia and reperfusion in the pig.
- 2002
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 24:2, s. 150-155
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate continuous saline tonometry for detection of progressive intestinal ischaemia and reperfusion in a porcine model. DESIGN: In eight anaesthetised pigs, small bowel mucosal pCO2 was recorded by means of two identical equipments for continuous saline tonometry and a standard tonometry balloon during ischaemia and reperfusion. RESULTS: Both systems of saline tonometry functioned stably during the four hour protocol ischaemia, although not significant until after 45 min for one of the tonometers. CONCLUSION: The equipment for continuous saline tonometry has a good reactivity, an accuracy comparable with standard tonometry.
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| 70. |
- Hallman, Mats, et al.
(författare)
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A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture.
- 2002
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786 .- 1942-4434. ; 17:5, s. 635-643
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: This study was designed to clinically and histologically evaluate the integration of titanium implants in different grafting materials used for maxillary sinus augmentation procedures. MATERIALS AND METHODS: A total of 21 patients and 36 maxillary sinuses were augmented with (1) autogenous particulated bone from the mandibular ramus, (2) bovine hydroxyapatite (BH) with membrane coverage, or (3) an 80/20 mixture of BH and autogenous bone. The grafts were allowed to heal for 6 to 9 months prior to placement of microimplants for histology and standard implants for prosthetic rehabilitation. After another 6 months of healing, when abutments were connected, the microimplants were retrieved for histologic and morphometric analyses. The outcome of the standard implants was clinically evaluated after 1 year of loading. RESULTS: The mean bone-implant contact was 34.6 +/- 9.5%, 54.3 +/- 33.1%, and 31.6 +/- 19.1% for autogenous bone, mixture of 20% autogenous bone/80% BH, and 100% BH, respectively. The corresponding values for the bone area parameter were 37.7 +/- 31.3%, 39.9 +/- 8%, and 41.7 +/- 26.6%. The BH area was found to be 12.3 +/- 8.5% and 11.8 +/- 3.6% for 20% autogenous bone/80% BH and 100% BH, respectively. There were no statistically significant differences for any parameter between any of the groups. After 1 year of loading, 6 of the 33 implants placed in autogenous bone grafts, 2 of the 35 implants placed in the BH/autogenous bone mixture, and 2 of 43 implants placed in BH were lost. There were no statistically significant differences between any of the groups. DISCUSSION: The histomorphometric analysis showed no differences between the 3 groups, indicating that autogenous bone graft can be substituted with bovine hydroxyapatite to 80% or 100% when used for maxillary sinus floor augmentation. The effect of adding autogenous bone remains unclear but may allow for a reduction of the healing time. CONCLUSION: The results from this clinical and histologic study indicate that similar short-term results can be expected when using autogenous bone, BH, or a mixture of them for maxillary sinus floor augmentation and delayed placement of dental implants.
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