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Träfflista för sökning "LAR1:gu ;lar1:(his);srt2:(2005-2009)"

Sökning: LAR1:gu > Högskolan i Skövde > (2005-2009)

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1.
  • Adamovic, Tatjana, 1974, et al. (författare)
  • Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor development.
  • 2007
  • Ingår i: Genes, chromosomes & cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 46:5, s. 459-69
  • Tidskriftsartikel (refereegranskat)abstract
    • Estrogens play an important role in breast cancer etiology and the ACI rat provides a novel animal model for defining the mechanisms through which estrogens contribute to mammary cancer development. In crossing experiments between the susceptible ACI strain and two resistant strains, COP (Copenhagen) and BN (Brown Norway), several quantitative trait loci (QTL) that affect development of 17beta-estradiol (E2)-induced mammary tumors have been defined. Using comparative genomic hybridization (CGH), we have analyzed cytogenetic aberrations in E2-induced mammary cancers and have found clear patterns of nonrandom chromosomal involvement. Approximately two thirds of the tumors exhibited copy number changes. Losses of rat chromosome 5 (RNO5) and RNO20 were particularly common, and it was found that these two aberrations often occurred together. A third recurrent aberration involving proximal gain and distal loss in RNO6 probably defined a distinct subgroup of tumors, since it never occurred in combination with RNO5 loss. Interestingly, QTL with powerful effects on mammary cancer development have been mapped to RNO5 and RNO6. These findings suggest that there were at least two genetic pathways to tumor formation in this rat model of E2-induced mammary cancer. By performing CGH on mammary tumors from ACI rats, F1 rats from crosses between the ACI and COP or BN strains and ACI.BN-Emca8 congenic rats, which carry the BN allele of the Emca8 QTL on RNO5 on the ACI genetic background, we were able to determine that the constitution of the germ line influences the pattern of chromosomal aberrations.
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2.
  • Adamovic, Tatjana, 1974, et al. (författare)
  • Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping.
  • 2005
  • Ingår i: Genes, chromosomes & cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 44:2, s. 139-53
  • Tidskriftsartikel (refereegranskat)abstract
    • The inbred BDII rat is a valuable experimental model for the genetic analysis of endometrial adenocarcinoma (EAC). One common aberration detected by comparative genomic hybridization in rat EAC was gain/amplification affecting the proximal part of rat chromosome 6 (RNO6). We applied rat and mouse chromosome painting probes onto tumor cell metaphase preparations in order to detect and characterize gross RNO6 aberrations. In addition, the RNO6q11-q16 segment was analyzed by fluorescence in situ hybridization with probes representing 12 cancer-related genes in the region. The analysis revealed that seven tumors contained large RNO6-derived homogeneously staining regions (HSRs) in addition to several normal or near-normal RNO6 chromosomes. Five tumors (two of which also had HSRs) exhibited a selective increase of the RNO6q11-q16 segment, sometimes in conjunction with moderate amplification of one or a few genes. Most commonly, the amplification affected the region centered around band 6q16 and included the Mycn, Ddx1, and Rrm2 genes. A second region, centering around Slc8a1 and Xdh, also was affected by gene amplification but to a lesser extent. The aberrations in the proximal part of RNO6 were further analyzed using allelotyping of microsatellite markers in all tumors from animals that were heterozygous in the proximal RNO6 region. We could detect allelic imbalance (AI) in 12 of 20 informative tumors, 6 of which were in addition to those already analyzed by molecular cytogenetic methods as described. Our findings suggest that increase/amplification of genes in this chromosome region contribute to the development of this hormone-dependent tumor.
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4.
  • Andersson, Peter (författare)
  • Modalitet och förändring : En studie av må och kunna i fornsvenska
  • 2007
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis investigates the development of root and non-root meanings of modal verbs through an empirical study of the verbs må and kunna in Old Swedish. Modality is taken to refer domains in which possibility contrasts with necessity. In Old Swedish, må (magha) and kunna 'may' and kunna 'can' have the potential to express most of the meanings relating to possibility and necessity, as well as lexical meanings. The two verbs are investigated in an Old Swedish corpus consisting of legal and religious texts. Certain default correlations between type of modal and semantic and syntatic enviroments, which have been proposed in the litterature, are investigated. The result shows that må frequently expresses participant-internal possibility, 'ability' and deonic possibility, 'permission', whereas kunna is mainly associated with participant-internal and general external possibility. Of particular interest is the use of må in conditions, which provides evidence that this construction type may have played a bridging role in the development on non-root modality. Using the framework of force dynamics, the development of modal meaning is analysed as a metamorphical transfer of one consistent image-schema between different conceptual domains. the schematic components are described in terms of forces and barriers. The proposed transfer from a physical to a social domain and further on to a mental and a conversional domain provides a good account of the diachronic development.
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5.
  • Andersson, Susanne, et al. (författare)
  • It's up to me! Experiences of living with pre-diabetes and the increased risk of developing type 2 diabetes mellitus
  • 2008
  • Ingår i: Primary Care Diabetes. - Amsterdam : Elsevier. - 1751-9918 .- 1878-0210. ; 2:4, s. 187-193
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: To explore experiences of pre-diabetes and the associated increased risk of type 2 diabetes mellitus. Methods: Eight participants with pre-diabetes were interviewed for a 45-60 min period. The interviews were audio taped, transcribed verbatim and analysed using a phenomenological hermeneutic approach. Results: Living with pre-diabetes means existing on the borderline of being healthy and suffering from T2DM. Three themes were formulated; "seeing possibilities in an uncertain future", "facing obstacles and loss of liberty" and "balancing between possibilities and obstacles" Being on the borderline and balancing between possibilities and obstacles were interpreted as a distressing feeling of being at increased risk of developing T2DM, although this feeling can change to one of either facing possibilities or facing obstacles. Conclusions: Special focus must be directed towards persons with pre-diabetes, as they are caught between possibilities and obstacles. Advanced care in the form of health dialogues can convince these people of their own abilities to influence the outcome of pre-diabetes. The result of this study can guide health care practitioners in comprehending each participant's understanding of the situation, thus helping them to create pedagogical dialogues in which patients' experiences, conceptions, explanations as well as explicit and implicit questions are identified. © 2008 Primary Care Diabetes Europe.
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7.
  • Andersson, Thomas, 1970, et al. (författare)
  • Identity processes of temporary organizations
  • 2007
  • Ingår i: Nordic Academy of Management Conference (NFF) in Bergen, Norway August 9-11, 2007..
  • Konferensbidrag (refereegranskat)
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10.
  • Arvidsson, Daniel, 1974, et al. (författare)
  • Energy Cost in Children Assessed by Multisensor Activity Monitors
  • 2009
  • Ingår i: Medicine & Science in Sports & Exercise. - : American College of Sports Medicine. - 0195-9131 .- 1530-0315. ; 41:3, s. 603-611
  • Tidskriftsartikel (refereegranskat)abstract
    •  Purpose: The SenseWear Pro2 Armband (SWA; BodyMedia, Inc., Pittsburg, PA), the Intelligent Device for Energy Expenditure and Activity (IDEEA; Minisun LLC, Fresno, CA), and the ActiReg (AR; PreMed AS, Oslo, Norway) were compared with indirect calorimetry to determine the ability of these devices to assess energy cost in children during resting and different physical activities. Methods: Fourteen children, 11–13 yr old, wore the SWA, the IDEEA, and the AR during resting, sitting, stationary bicycling, jumping on a trampoline, playing basketball, stair walking, and walking/running along a 50-m track. The Oxycon Mobile portable metabolic system (VIASYS Healthcare, Conshohocken, PA) was used as the criterion method for energy cost. Results: For resting and sitting, the three activity monitors showed comparable results, but none of them accurately assessed energy cost for stationary bicycling, jumping on a trampoline, or playing basketball. The IDEEA was the only activity monitor that accurately assessed energy cost for stair walking. Also, the IDEEA showed a close estimate of energy cost across the walking and the running intensities, whereas the SWA accurately assessed energy cost for slow to normal walking but showed increased underestimation of energy cost with increasing speed. The AR overestimated energy cost during walking and during slow running but did not respond to increasing running speed. Conclusions: To be able to capture children’s physical activity, all three activity monitors need to be further developed. Overall, the IDEEA showed the highest ability to assess energy cost in this study, but SWA may be more feasible for use in children under free-living conditions. 
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