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Search: swepub > Umeå University > (2000-2004) > Journal article > (2001) > Örebro University

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  • Rask, Eva, 1958-, et al. (author)
  • Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
  • 2001
  • In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 24:9, s. 1640-1645
  • Journal article (peer-reviewed)abstract
    • OBJECTIVE:To investigate whether features of the insulin resistance syndrome are associated with altered incretin responses to food intake.RESEARCH DESIGN AND METHODS:From a population-based study, 35 men were recruited, representing a wide spectrum of insulin sensitivity and body weight. Each subject underwent a hyperinsulinemic-euglycemic clamp to determine insulin sensitivity. A mixed meal was given, and plasma levels of gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), as well as insulin, glucagon, and glucose were measured.RESULTS:Insulin resistance was associated with impaired GIP and GLP-1 responses to a mixed meal. The total area under the curve (AUC) of the GIP response after the mixed meal was associated with insulin sensitivity (r = 0.54, P < 0.01). There was a significant difference between the highest and the lowest tertile of insulin sensitivity (P < 0.05). GLP-1 levels 15 min after food intake were significantly lower in the most insulin-resistant tertile compared with the most insulin-sensitive tertile. During the first hour, the AUC of GLP-1 correlated significantly with insulin sensitivity (r = 0.47, P < 0.01). Multiple linear regression analysis showed that insulin resistance, but not obesity, was an independent predictor of these decreased incretin responses.CONCLUSIONS:In insulin resistance, the GIP and GLP-1 responses to a mixed meal are impaired and are related to the degree of insulin resistance. Decreased incretin responsiveness may be of importance for the development of impaired glucose tolerance.
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Type of publication
journal article  (2)Undo refine
Type of content
peer-reviewed (2)
Author/Editor
Ahren, B (1)
Tysklind, Mats (1)
Olsson, Tommy (1)
Holst, J J (1)
Söderberg, Stefan (1)
Rask, Eva, 1958- (1)
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Norrgren, Leif (1)
Andersson, Patrik (1)
Berg, A H (1)
Bjerselius, Rickard (1)
Olsén, K Håkan (1)
Olsson, Per-Erik, 19 ... (1)
Örn, S (1)
Johnson, Owe (1)
Seckl, J. (1)
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University
Umeå University  (2)Undo refine
Örebro University  (2)Undo refine
Uppsala University (1)
Södertörn University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Year
2001 (2)Undo refine

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