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- Frescatada-Rosa, Marcia, et al.
(författare)
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High lipid order of Arabidopsis cell-plate membranes mediated by sterol and DYNAMIN-RELATED PROTEIN1A function
- 2014
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Ingår i: The Plant Journal. - : Wiley. - 0960-7412 .- 1365-313X. ; 80:5, s. 745-757
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Tidskriftsartikel (refereegranskat)abstract
- Membranes of eukaryotic cells contain high lipid-order sterol-rich domains that are thought to mediate temporal and spatial organization of cellular processes. Sterols are crucial for execution of cytokinesis, the last stage of cell division, in diverse eukaryotes. The cell plate of higher-plant cells is the membrane structure that separates daughter cells during somatic cytokinesis. Cell-plate formation in Arabidopsis relies on sterol- and DYNAMIN-RELATED PROTEIN1A (DRP1A)-dependent endocytosis. However, functional relationships between lipid membrane order or lipid packing and endocytic machinery components during eukaryotic cytokinesis have not been elucidated. Using ratiometric live imaging of lipid order-sensitive fluorescent probes, we show that the cell plate of Arabidopsis thaliana represents a dynamic, high lipid-order membrane domain. The cell-plate lipid order was found to be sensitive to pharmacological and genetic alterations of sterol composition. Sterols co-localize with DRP1A at the cell plate, and DRP1A accumulates in detergent-resistant membrane fractions. Modifications of sterol concentration or composition reduce cell-plate membrane order and affect DRP1A localization. Strikingly, DRP1A function itself is essential for high lipid order at the cell plate. Our findings provide evidence that the cell plate represents a high lipid-order domain, and pave the way to explore potential feedback between lipid order and function of dynamin-related proteins during cytokinesis.
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- Holmberg, Tora
(författare)
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Samtal om biologi : genusforskare talar om kön och kropp
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Förståelsen av kroppar och kroppslighet har under de senaste decennierna varit central för genusforskningen. Frågan om genusvetenskapens relation till "det biologiska" har därmed blivit alltmer brännande. I denna skrift undersöker och belyser Tora Holmberg gränserna mellan det sociala och det biologiska, mellan natur och kultur, mellan kön och genus, och olika genusteoretiska debatter. Hon gör det genom samtal med i Sverige framträdande genusforskare som intresserat sig för kroppslighet och biologiskt kön. Tillsammans utforskar de problem med olika angreppssätt och möjligheterna till överskridanden.
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- Ji, Qinglei, et al.
(författare)
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Design and calibration of 3D printed soft deformation sensors for soft actuator control
- 2023
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Ingår i: Mechatronics (Oxford). - : Elsevier BV. - 0957-4158 .- 1873-4006. ; 92, s. 102980-102980
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Tidskriftsartikel (refereegranskat)abstract
- Soft actuators made from compliant materials are superior to conventional rigid robots in terms of flexibility, adaptability and safety. However, an inherent drawback of soft actuator is the low actuation precision. Implementing closed loop control is a possible solution, but the soft actuator shape can hardly be measured directly by commercially available sensors, which either are too stiff for integration or cause performance degradation of the actuator. Although 3D printing has been applied to print bendable sensors from conductive materials, they either have larger stiffness than the soft actuator or are made from specially designed materials that are difficult to reproduce. In this study, easily accessible commercial soft conductive material is applied to directly 3D print soft sensors on soft actuators. Different configurations of the printed sensors are studied to investigate how the sensor design affects the performance. The best sensor configuration is selected to provide shape feedback using its changing resistance during deformation. Compared with a commercial flexible bending sensor, the printed sensor has less influences on the soft actuator performance and enjoys higher shape estimation accuracy. Closed loop shape control of the actuator using feedback from the 3D printed sensor is then designed, implemented and compared with the control results using image feedback. A gripper consisting of three individually controlled soft actuators demonstrates the applications of the soft sensor.
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- Johansson, Ann, et al.
(författare)
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Fluorescence and absorption assessment of a lipid mTHPC formulation following topical application in a non-melanotic skin tumor model.
- 2007
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Ingår i: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668. ; 12:3, s. 034026-034026
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Tidskriftsartikel (refereegranskat)abstract
- Although the benefits of topical sensitizer administration have been confirmed for photodynamic therapy (PDT) ALA-induced, protoporphyrin IX is the only sensitizer clinically used with this administration route. Unfortunately, ALA-PDT results in poor treatment response for thicker lesions. Here, selectivity and depth distribution of the highly potent sensitizer meso-tetra(hydroxyphenyl)chlorin (mTHPC), supplied in a novel liposome formulation was investigated following topical administration for 4 and 6 h in a murine skin tumor model. Extraction data indicated an average [standard deviation (SD)] mTHPC concentration within lesions of 6.0(+/- 3.1) ng/mg tissue with no significant difference (p<0.05) between 4- and 6-h application times and undetectable levels of generalized photosensitivity. Absorption spectroscopy and chemical extraction both indicated a significant selectivity between lesion and normal surrounding skin at 4 and 6 h, whereas the more sensitive fluorescence imaging setup revealed significant selectivity only for the 4-h application time. Absorption data showed a significant correlation with extraction, whereas the results from the fluorescence imaging setup did not correlate with the other methods. Our results indicate that this sensitizer formulation and administration path could be interesting for topical mTHPC-PDT, decreasing the effects of extended skin photosensitivity associated with systemic mTHPC administration. (C) 2007 Society of Photo-Optical instrumentation Engineers.
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- Johansson-Pajala, Rose-Marie, et al.
(författare)
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Anxiety and loneliness among older people living in residential care facilities or receiving home care services in Sweden during the COVID-19 pandemic : a national cross-sectional study
- 2022
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Ingår i: BMC Geriatrics. - : Springer Science and Business Media LLC. - 1471-2318 .- 1471-2318. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Older people were subjected to significant restrictions on physical contacts with others during the COVID-19 pandemic. Social distancing impacts older people’s experiences of anxiety and loneliness. Despite a large body of research on the pandemic, there is little research on its effects on older people in residential care facilities (RCF) and in home care services (HCS), who are the frailest of the older population. We aimed to investigate the effect of the first wave of the COVID-19 pandemic in March-May 2020 on experiences of anxiety and loneliness among older people living in RCF or receiving HCS and the impact of the progression of the pandemic on these experiences.Methods: A retrospective cross-sectional design using data from the national user satisfaction survey (March − May 2020) by the Swedish National Board of Health and Welfare. Survey responses were retrieved from 27,872 older people in RCF (mean age 87 years) and 82,834 older people receiving HCS (mean age 84 years). Proportional-odds (cumulative logit) model was used to estimate the degree of association between dependent and independent variables.Results: Loneliness and anxiety were more prevalent among the older persons living in RCF (loneliness: 69%, anxiety: 63%) than those receiving HCS (53% and 47%, respectively). Proportional odds models revealed that among the RCF and HCS respondents, the cumulative odds ratio of experiencing higher degree of anxiety increased by 1.06% and 1.04%, respectively, and loneliness by 1.13% and 1.16%, respectively, for 1% increase in the COVID-19 infection rate. Poor self-rated health was the most influential factor for anxiety in both RCF and HCS. Living alone (with HCS) was the most influential factor affecting loneliness. Experiences of disrespect from staff were more strongly associated with anxiety and loneliness in RCF than in HCS.Conclusion: Older people in RCF or receiving HCS experienced increasing levels of anxiety and loneliness as the first wave of the pandemic progressed. Older people’ mental and social wellbeing should be recognized to a greater extent, such as by providing opportunities for social activities. Better preparedness for future similar events is needed, where restrictions on social interaction are balanced against the public health directives.
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- Johansson, Rolf
(författare)
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Brief announcement : KARYON
- 2012
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Ingår i: 14th International Symposium on Stabilization, Safety, and Security of Distributed Systems, SSS 2012.
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Konferensbidrag (refereegranskat)
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| 10. |
- Johansson, R, et al.
(författare)
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Measurement of the exclusive D(p,e(+)e(-))He-3 and D(p,gamma)He-3 reactions at 98 and 176 MeV
- 1998
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Ingår i: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 641:4, s. 389-400
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Tidskriftsartikel (refereegranskat)abstract
- A high resolution magnetic pair spectrometer for medium energy photons has been used for studies of the exclusive (p,e(+)e(-)) and (p, gamma) reactions on deuterium at 98 and 176 MeV. The (p, e(+)e(-)) cross sections, obtained at 40 degrees and 80 degrees
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