Tyck till om SwePub Sök
här!
Search: WFRF:(Seele J.)
> (2013)
> Other academic/artistic >
Identification of a...
Identification of a novel host-specific IgM protease in Streptococcus suis
-
- Seele, J. (author)
- University of Veterinary Medicine Hannover, Inst Microbiol, Hannover, Germany
-
- Singpiel, A. (author)
- University of Veterinary Medicine Hannover, Inst Microbiol, Hannover, Germany
-
- Spoerry, Christian (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR)
-
show more...
-
- von Pawel-Rammingen, Ulrich (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Valentin-Weigand, P. (author)
- University of Veterinary Medicine Hannover, Inst Microbiol, Hannover, Germany
-
- Baums, C. G. (author)
- University of Veterinary Medicine Hannover, Inst Microbiol, Hannover, Germany
-
show less...
-
(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
-
In: International Journal of Medical Microbiology. - : Elsevier. - 1438-4221 .- 1618-0607. ; 303:Suppl. 1, MPP35, s. 58-58
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Streptococcus (S.) suis is an important invasive, extracellular pathogen in pigs, which causes meningitis, arthritis, serositis and other diseases. Furthermore, it is also an emerging zoonotic agent. This study was initiated by the finding that IgM degradation products are released after opsonization of S. suis with porcine serum. The objective of this work was to identify and characterize the factor responsible for IgM cleavage. The results showed that a protein of S. suis with high homology to the well characterized IgG endopeptidase of S. pyogenes IdeS (or Mac1) [1, 2], designated IdeSsuis, degrades immunoglobulins (Ig) of the isotype M, but not IgG, IgA or other proteins present in porcine cerebrospinal fluid, joint fluid or serum. Western Blot analysis revealed that IdeSsuis is host-specific as it exclusively cleaves porcine IgM but not IgM from six other species. Flow cytometry and immunofluorescence microscopy demonstrated that this protein modulates binding of IgM to the bacterial surface. Furthermore the isogenic ideSsuis deletion mutant is significantly attenuated in survival in porcine blood [3]. IdeSsuis is the first prokaryotic IgM-specific protease described indicating a novel host-pathogen interaction at an early stage of the host immune response. Furthermore cleavage of porcine IgM by IdeSsuis is the first identified phenotype reflecting functional adaptation of S. suis to pigs as the main host.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
To the university's database