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Sökning: swepub > Umeå universitet > Tidskriftsartikel > (1995-1999) > (1998)

  • Resultat 231-240 av 292
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231.
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232.
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233.
  • Rasmusson, Arne (författare)
  • Utan kyrka, ingen kristen etik
  • 1998
  • Ingår i: Svensk Teologisk Kvartalsskrift. ; 74:1, s. 24-34
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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234.
  • Rosenquist, R, et al. (författare)
  • Low rate of somatic hypermutations characterize progressive B-cell lymphomas.
  • 1998
  • Ingår i: European Journal of Haematology. - 0902-4441 .- 1600-0609. ; 61:3, s. 164-72
  • Tidskriftsartikel (refereegranskat)abstract
    • Immunoglobulin heavy (IgH) chain gene rearrangements were characterized in 40 samples from 15 patients with B-cell lymphomas at different time points during tumour progression. Using polymerase chain reaction (PCR) amplification and single strand conformation polymorphism (SSCP) analysis of variable heavy (VH) chain gene segments, we found that 6 cases displayed alterations in their IgH chain rearrangements at relapse. These alterations were mainly observed in follicular or transformed lymphomas, but no association to clinical features was found. Nucleotide sequence analysis revealed a low frequency of mutations in 3 cases, whereas 1 case displayed an extensive mutation rate in a compartment with transformed morphology at relapse. The mutations observed most probably resulted from somatic hypermutations. Further, the mutations were scattered randomly over the VH gene segment and no significant bias favouring amino acid substitutions was observed in 3 cases, suggesting that the tumour cells had not been subjected to antigen-driven selection. In 1 case, however, the mutation pattern indicated that the tumour cells had been affected by an antigen selection process. In the 2 remaining cases, the original V(H)DJ(H) rearrangement could no longer be detected by VH gene family specific PCR at relapse, but using primers specific for the framework region 2 or 3 altered rearrangements were demonstrated, implying that mutations had been introduced in framework region 1. However, the majority of the tumour cell clones analysed were relatively stable during tumour progression, which make them eligible for analysis of minimal residual disease using the VH gene regions as molecular markers.
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235.
  • Rydh, Anders, et al. (författare)
  • Serum amyloid P component scintigraphy in familial amyloid polyneuropathy : regression of visceral amyloid following liver transplantation.
  • 1998
  • Ingår i: European Journal of Nuclear Medicine. - 0340-6997 .- 1432-105X. ; 25:7, s. 709-713
  • Tidskriftsartikel (refereegranskat)abstract
    • Familial amyloid polyneuropathy (FAP) associated with transthyretin (TTR) mutations is the commonest type of hereditary amyloidosis. Plasma TTR is produced almost exclusively in the liver and orthotopic liver transplantation is the only available treatment, although the clinical outcome varies. Serum amyloid P component (SAP) scintigraphy is a method for identifying and quantitatively monitoring amyloid deposits in vivo, but it has not previously been used to study the outcome of visceral amyloid deposits in FAP following liver transplantation. Whole body scintigraphy following injection of iodine-123 labelled SAP was performed in 17 patients with FAP associated with TTR Met30 and in five asymptomatic gene carriers. Follow-up studies were performed in ten patients, eight of whom had undergone orthotopic liver transplantation 1-5 years beforehand. There was abnormal uptake of 123I-SAP in all FAP patients, including the kidneys in each case, the spleen in five cases and the adrenal glands in three cases. Renal amyloid deposits were also present in three of the asymptomatic carriers. Follow-up studies 1-5 years after liver transplantation showed that there had been substantial regression of the visceral amyloid deposits in two patients and modest improvement in three cases. The amyloid deposits were unchanged in two patients. In conclusion, 123I-SAP scintigraphy identified unsuspected visceral amyloid in each patient with FAP due to TTR Met30. The universal presence of renal amyloid probably underlies the high frequency of renal failure that occurs in FAP following liver transplantation. The variable capacity of patients to mobilise amyloid deposits following liver transplantation may contribute to their long-term clinical outcome.
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236.
  • Rönnqvist, Louise, 1957-, et al. (författare)
  • Head position preference in the human newborn : a new look
  • 1998
  • Ingår i: Child Development. - : Blackwell Publishing. - 0009-3920 .- 1467-8624. ; 69:1, s. 13-23
  • Tidskriftsartikel (refereegranskat)abstract
    • Head position preference was studied in 20 awake newborns who differed in terms of delivery and sex. They were placed supine on a custom-built platform to reduce the effects of gravity and asymmetries in trunk posture and skull shape. A global and a specific scoring method were used, the infants being in State 3 (quiet wakefulness) or 4 (active wakefulness, excluding crying). Delivery and sex did not account for differences in head position. The head turned more often to the right and was maintained longer in this position during State 3, regardless of scoring method. The maintenance of the head in midline was comparable in duration to that reported for infants at 2–3 months when using the global scoring method. This suggests that the neural mechanisms responsible for attaining and maintaining a midline position are present at birth, but are not functionally expressed due to a lack of adequate power in the antigravity muscles of the neck.
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237.
  • Rönnqvist, Louise, 1957-, et al. (författare)
  • Lateral biases in head turning and the Moro response in the human newborn : are they both vestibular in origin?
  • 1998
  • Ingår i: Developmental Psychobiology. - 0012-1630 .- 1098-2302. ; 33:4, s. 339-349
  • Tidskriftsartikel (refereegranskat)abstract
    • Head turning after release from the midline and the Moro response to a full-body drop in 15 full-term newborns lying supine on a custom-built platform was studied. While the lateral bias for head turning was not as pronounced as for the Moro response, it was still assumed in the ratio of 2 (right):1 (left) as predicted by Previc (1991). Onset latency and time-to-peak acceleration were both significantly shorter in the right arm during the initial phase of the Moro response. For both measures, this right arm bias persisted over four consecutive elicitations in most infants. Vaginally delivered infants and those born by Caesarean section did not differ in terms of head preference and the two measures of arm advantage. Our main finding was that infants with a right-sided head preference had a consistently shorter onset latency for the right arm. We interpret this association as stemming from a common labyrinthine asymmetry that involves different vestibulospinal pathways for the neck and arm muscles. In general, our findings are discussed in the context of Previc's (1991) left-otolithic dominance hypothesis and Grattan, De Vos, Levy, and McClintock's (1992) model of newborn functional asymmetries.
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238.
  • Saarento, O, et al. (författare)
  • The Nordic comparative study on sectorised psychiatry : repeated emergency admissions to inpatient care during a 1-year follow-up.
  • 1998
  • Ingår i: European psychiatry. - 0924-9338 .- 1778-3585. ; 13:8, s. 385-91
  • Tidskriftsartikel (refereegranskat)abstract
    • The emergency admissions to hospital care in six psychiatric services in four Nordic countries were explored as a part of a Nordic comparative study on sectorised psychiatry. One year treated incidence cohorts were used, with the total cohort comprising 2,454 patients. Of the 803 patients who were admitted to inpatient care during a 1-year follow-up, 82% had at least one emergency admission and 23% repeated emergency admissions. The definition for the repeated emergency admissions was at least two admissions during the follow-up. The mean length of stay in emergency inpatient care per treatment episode for this patient subgroup was 28 days. Their emergency inpatient episodes constituted 30% of all inpatient days during the follow-up. However, the variations between the services and diagnostic subgroups were large. The results of a logistic regression analysis indicated that the following variables predicted repeated emergency admissions: inpatient care at index contact, emergency outpatient contacts or no planned hospital admissions during the follow-up, psychiatric service, age under 45 years, and a diagnosis of psychosis, personality disorder or dependency. The repeated emergency admissions were related to the existence of a special service unit for abusers but not to the rates of outpatient staff or acute beds in the services, to geographical distances, referral practice or existence of emergency services.
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239.
  • Saarento, O, et al. (författare)
  • The Nordic Comparative Study on Sectorized Psychiatry : patients who use only psychiatric in-patient care in comprehensive community-based services--a 1-year follow-up study.
  • 1998
  • Ingår i: Acta Psychiatrica Scandinavica. - 0001-690X .- 1600-0447. ; 98:2, s. 98-104
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present paper a sample of patients using psychiatric in-patient care only is characterized and analysed with regard to characteristics of the psychiatric services. This paper forms part of the Nordic Comparative Study on Sectorized Psychiatry, designed to investigate contact rates and use of psychiatric care by new patients in 7 catchment areas in 4 Nordic countries during a 1-year follow-up. One-year treated incidence cohorts were used. The logistic regression analysis revealed that the variable 'psychiatric service' was one of the statistically significant determinants of using only in-patient care during the follow-up. The diagnostic groups with the highest probability of using only in-patient care were dependencies and functional psychoses. The following factors were associated with a high risk of using only in-patient care: older age, being referred by another psychiatrist, having received previous psychiatric in-patient care, male sex, being retired, and not living with one's parents or a partner. Patients who used only in-patient care had fewer admissions and days in in-patient care than others during the 1-year follow-up period. Lack of 24-hour emergency services in out-patient care correlated positively with the use of only in-patient care.
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240.
  • Saarento, O, et al. (författare)
  • The Nordic Comparative Study on Sectorized Psychiatry : continuity of care related to characteristics of the psychiatric services and the patients.
  • 1998
  • Ingår i: Social Psychiatry and Psychiatric Epidemiology. - 0933-7954 .- 1433-9285. ; 33:11, s. 521-7
  • Tidskriftsartikel (refereegranskat)abstract
    • The problem addressed in this paper is how continuity of care is related to characteristics of psychiatric services, previous events in a patient's pattern of care and patient characteristics. The present paper is a part of a Nordic Comparative Study on Sectorized Psychiatry in seven catchment areas in four Nordic countries. One-year-treated-incidence cohorts were used. Each patient was followed for 1 year after the first contact with the psychiatric service. Continuity of care was measured by the time from discharge from hospital to the first subsequent day-patient or outpatient contact. Notable findings were large differences in the continuity of care in the seven services, high proportions of discharges without any aftercare contacts and long time lags between discharges and aftercare contacts in most of the catchment areas. A Cox regression analysis revealed that aftercare following hospitalisation seems to be more probable if the outpatient services are located geographically close to the patients, if the hospitalisation lasted between 2 and 4 weeks, if there was a community care contact shortly before the hospital admission and if the patient is not retired and not divorced. Staff resources were not related to continuity of care.
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