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- Grenholm, Cristina
(författare)
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Romans Interpreted : A Comparative Analysis of the Commentaries of Barth, Nygren, Cranfield and Wilckens on Paul´s Epistle to the Romans
- 1990
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with the problem of how to explain different interpretations of Paul's Epistle to the Romans in the four contemporary commentaries of Karl Barth, Anders Nygren, Charles Cranfield and Ulrich Wilckens. The purpose of this study is to put forward and analyse the different interpretations given by the commentators and to examine some ways in which these differences may be explained.The differences analysed primarily concern central theological issues. A detailed description of the four different interpretations of Romans is given on three levels: (i) concerning Romans 7, (ii) concerning some theological themes in Romans and (iii) concerning some general remarks on Romans which are important for the interpretation of the Epistle.Different kinds of interpretations are defined by the development of a theory of interpretation which focuses on the arguments supporting the commentators' choices of interpretation. The different interpretations of Romans are explained by reference to the commentators' pursuit of different combinations of kinds of interpretations and by the contents of their arguments. Explanations are also found in their pursuit of different combinations of purposes. Their views of the contents of Christian faith, revelation and the Bible also explain the different interpretations. Special attention is paid to a fundamental lack of clarity in the commentaries concerning the relation between reconstructive and constructive interpretations, the problem of application.The commentaries are used as examples of biblical interpretation to arrive at a detailed knowledge of the complex process of interpretation. Distinctions are developed concerning kinds of interpretations, kinds of purposes and different views of revelation and the Bible
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- Mehmet, Huseyin, et al.
(författare)
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Early signals in the mitogenic response of Swiss 3T3 cells : a comparative study of purified PDGF homodimers
- 1990
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Ingår i: Growth Factors. - : Taylor & Francis. - 0897-7194 .- 1029-2292. ; 3:2, s. 83-95
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Tidskriftsartikel (refereegranskat)abstract
- Platelet-derived growth factor (PDGF) occurs as three dimeric isoforms, AA, BB, and AB. Two distinct receptor subunits, alpha and beta, have been identified which bind either all three isoforms of PDGF (alpha) or PDGF-BB only (beta). Here, we have compared the effect of purified PDGF homodimers on the early intracellular signaling events and mitogenesis in Swiss 3T3 cells, which possess equivalent numbers of the alpha and beta subunits. Both PDGF-AA and PDGF-BB stimulated receptor phosphorylation, inositol phosphate formation, activation of protein kinase C, calcium mobilization, EGF receptor transmodulation, sodium uptake, arachidonic acid release, cyclic AMP accumulation, and c-fos induction in a comparable, dose-dependent manner (half-maximal values for all these response were in the 2-10 ng/ml range for both homodimers). At high concentrations of PDGF (greater than 10 ng/ml), the BB homodimer effect on early membrane and cytosolic signals was 20-30% greater than PDGF-AA, reflecting the greater number of available binding sites for PDGF-BB. DNA synthesis studies indicated that PDGF-AA and PDGF-BB were potent mitogens for Swiss 3T3 cells, displaying identical dose-response effects. Moreover, the mitogenic activities of both homodimers were equally potentiated in the presence of insulin. These results indicate that both PDGF-AA and PDGF-BB stimulate the full complement of molecular responses required for the synergistic interactions mediating long-term mitogenesis. We conclude that alpha and beta receptor subunits do not differ in their ability to transduce PDGF-mediated signals leading to DNA synthesis in Swiss 3T3 cells.
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- Micheletti, Michele
(författare)
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Interessengruppen im postindustriellen Schweden
- 1990
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Ingår i: Jahrbuch zur Staats- und Verwaltungswissenschaft (4) (1990): 191 - 226. ; :4, s. 191-226
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Nånberg, Eewa, 1957-, et al.
(författare)
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Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation
- 1990
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Ingår i: Journal of Cellular Physiology. - : Wiley-Blackwell Publishing Inc.. - 0021-9541 .- 1097-4652. ; 143:2, s. 232-242
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Tidskriftsartikel (refereegranskat)abstract
- To elucidate the transmembrane signalling processes initiated by fibroblast growth factor (FGF), we have studied the effect of recombinant basic FGF (bFGF) on various early events associated with mitogenesis in Swiss 3T3 fibroblasts. bFGF, at mitogenic concentrations, neither induced Ca2+ mobilization from intracellular stores nor increased the accumulation of inositol phosphates. In contrast, bFGF stimulated the phosphorylation of the Mr 80,000 (80K) cellular protein which is a major substrate of protein kinase C. This effect was potentiated by the diacylglycerol kinase inhibitor R59022. Two-dimensional polyacrylamide gel electrophoresis and phosphopeptide mapping showed that the 80K phosphoproteins generated in response to bFGF, bombesin, and phorbol 12,13-dibutyrate were indistinguishable. Down-regulation of protein kinase C prevented bFGF stimulation of 80K phosphorylation. Other protein kinase C-dependent early events such as transmodulation of the epidermal growth factor receptor, cytoplasmic alkalinization, inhibition of vasopressin induced increase in cytosolic [Ca2+], and enhancement of cAMP accumulation in response to forskolin were also induced by bFGF. Similar results were obtained when bFGF was added to quiescent cultures of tertiary mouse embryo fibroblasts. We conclude that bFGF stimulates protein kinase C through a signal transduction pathway distinct from inositol phospholipid turnover and Ca2+ mobilization.
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