| 1. |
- Axelsson, Åsa B., 1955, et al.
(författare)
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How bystanders perceive their cardiopulmonary resuscitation intervention : a qualitative study
- 2000
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Ingår i: Resuscitation. - Amsterdam : Elsevier. - 0300-9572 .- 1873-1570. ; 47:1, s. 71-81
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Tidskriftsartikel (refereegranskat)abstract
- The importance of bystander cardiopulmonary resuscitation (CPR) prior to arrival of the emergency medical service is well documented. In Sweden, CPR is initiated prior to emergency medical services (EMS) arrival in about 30% of cardiac arrests out-of-hospital, a figure which should be improved urgently. To do so, it is of interest to know more about the bystanders' perceptions of their intervention. A qualitative method inspired by the phenomenographic approach was applied to 19 bystanders who had performed CPR. In the analysis, five main categories and 14 subcategories emerged. The main categories were: to have a sense of humanity, to have competence, to feel an obligation, to have courage and to feel exposed. Interviews described how humanity and concern for another human being were the foundation of their intervention. CPR training offers the possibility to give appropriate help in this emergency. If the aim of CPR training was extended beyond teaching the skill of CPR to include preparation of the rescuer for the intervention and his/her reactions, this might increase the number of people able to take action in the cardiac arrest situation.
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| 2. |
- Bergquist, Magnus, 1960, et al.
(författare)
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Practising Peer Review in Organizations: a Qualifier for Knowledge Dissemination and Legitimization
- 2001
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Ingår i: Journal of Information Technology. - London : SAGE Publications. ; 16:2, s. 99-112
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Tidskriftsartikel (refereegranskat)abstract
- A key issue in many organizations is how to disseminate information in an effective way and, more importantly, how to make use of this information in order to create new knowledge. One way of addressing this problem is to focus on how information is socially transformed into knowledge. This includes how knowledge is handled in practice and how the knowledge produced is qualiŽ ed as being something worth knowing and acting upon. Two well-established practices for doing this are the refereeing system and the peer review process. These are used in scientiŽ c communities as a means of validating and legitimating knowledge, for example by reviewing journal papers before publishing or project proposals before granting funds, etc. This paper argues that peer review is a useful concept when looking at knowledge creation and legitimization in organizations. The social meaning of peer review is to legitimize new knowledge by organizationally sanctioning it and thereby creating a platform for collective sense making. This paper uses an example from a Ž eld study in a pharmaceutical company in order to illustrate this argument. The study took place in a quality support department where the quality of health care products and processes was assessed. The organization had a need for fast and reliable updating of information that could in uence how the production process of pharmaceuticals should be carried out. In order to cope with these problems the department established an ‘evaluation loop’, which shared several characteristics with the peer review process.
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| 3. |
- Bergquist, Magnus, 1960, et al.
(författare)
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The Power of Gifts: Organizing Social Relationships in Open Source Communities
- 2001
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Ingår i: Information Systems Journal. - Chichester : Wiley. ; 11:4, s. 305-320
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Tidskriftsartikel (refereegranskat)abstract
- In writings on the open source software development model, it is often argued that it is successful as a result of the gift economy that embraces activities in online communities. However, the theoretical foundations for this argument are seldom discussed and empirically tested. Starting with the ‘classic’ theories of gift giving, we discuss how they need to be developed in order to explain giftgiving practices in digital domains. In this paper, we argue that the gift economy is important, not only because it creates openness, but also because it organizes relationships between people in a certain way. Open source software development relies on gift giving as a way of getting new ideas and prototypes out into circulation. This also implies that the giver gets power from giving away. This power is used as a way of guaranteeing the quality of the code. We relate this practice to how gifts, in the form of new scientific knowledge, are given to the research community, and how this is done through peer review processes.
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| 4. |
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| 5. |
- Hansson, Ann-Sofie, et al.
(författare)
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Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease
- 2004
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Ingår i: American Journal of Pathology. - New York, NY : Elsevier. - 0002-9440 .- 1525-2191. ; 164:3, s. 959-966
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Tidskriftsartikel (refereegranskat)abstract
- Relapsing polychondritis is an autoimmune disease that affects cartilage in the ear, nose, and respiratory tract. A pathogenic immune response has been proposed and antibodies to several cartilage proteins are detected in sera from these patients. To investigate the role of the humoral immune response in relapsing polychondritis, we used the matrilin-1-induced relapsing polychondritis model. Mice deficient of B cells (muMT) and mice congenic at the complement factor 5, were immunized with matrilin-1, a cartilage-specific protein mainly detected in the tracheal cartilage. To investigate the binding properties and tissue selection of matrilin-1-specific antibodies we produced matrilin-1-specific B-cell hybridomas. Although 83% of the micro MT heterozygous mice developed respiratory distress and erosive chondritis in the respiratory tract, none of the B-cell-deficient mice were susceptible to disease. In addition, we show that complement factor 5 is important for the induction of matrilin-1-induced relapsing polychondritis. Monoclonal matrilin-1-specific antibodies injected into neonatal mice bound specifically to cartilage of the respiratory tract and adult B-cell-deficient mice injected with the same antibodies developed erosive chondritis in the respiratory tract. We conclude that relapsing polychondritis can be mediated by a pathway involving tissue-specific antibodies and complement activation.
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| 6. |
- Hietala, Max Albert, 1969, et al.
(författare)
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Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis.
- 2004
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Ingår i: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 34:4, s. 1208-16
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Tidskriftsartikel (refereegranskat)abstract
- To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3- and factor B (FB)-deficient (C3(-/-) and FB(-/-)) DBA/1J mice using well-defined monoclonal IgG2b and IgG2a antibodies to type II collagen. In control DBA/1J mice, severe swelling of the joints, destruction of cartilage and erosion of bone developed very rapidly with a 100% incidence and a peak on days 7-10. Although 75% of C3(-/-) mice developed arthritis, the clinical severity was very mild and the onset was delayed. Severity of arthritis in FB(-/-) mice ranked intermediate in comparison with C3(-/-) and control mice with an incidence of 100%. Immunohistochemical analysis of the inflamed joints demonstrated substantial reduction in macrophage and neutrophilic leukocyte infiltration in both C3(-/-) and FB(-/-) mice, thereby confirming the clinical findings. We conclude that both the classical and the alternative pathways of complement activation are involved in the effector phase of arthritis.
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| 7. |
- Ihlström Eriksson, Carina
(författare)
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The Evolution of a New(s) Genre
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis describes and analyzes how the online newspaper genre has evolved since its inception on the Internet in the mid-nineties. The overall research question is: What characterizes the online newspaper genre evolution? The thesis is based on both synchronic and diachronic studies with a multimethod approach (including six different studies involving, e.g., interviews, questionnaires and web site analyses) intended to provide a comprehensive picture of this genre evolution. On the basis of genre theory, the thesis proposes a framework for understanding online newspaper genre evolution, integrating design (layout) aspects with publisher and audience views. Applying this framework to the collected empirical material, the thesis presents a comprehensive and integrated view of this evolution. Over time, online newspapers have evolved into a specific digital genre, with genre characteristics such as content and form, distinguishing them from other digital genres. However, this rapid development has also lead to diversities in form and function, triggering both academics and practitioners to seek ways to design for consistency within the genre. Several factors have influenced the online newspaper genre evolution, e.g., inhouse attitudes, business model shifts and technological progress at the publishers’ side. The audience demographics, habits and preferences have also changed. The layout of the online newspapers has been altered into long pages stuffed with content like news streams, headlines, photos, and services not possible in the printed edition. There has also been a shift towards frequent updates throughout the day and more content produced for the web. In addition, the thesis contributes to digital genre theory by modifications relevant to the online newspaper genre. For example, the concepts of genre awareness and genre interdependence are elaborated, a framework for identifying genre characteristics is proposed, and the concept “positioning” is introduced. Further, the thesis also contributes with implications for online newspaper design and publishing with longitudinal mappings of online newspaper layout and the habits and preferences of the audience.
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| 8. |
- Jeppson, Kjell, 1947, et al.
(författare)
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Theory of a room-temperature silicon quantum dot device as a sensitive electrometer
- 2004
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Ingår i: Journal of Applied Physics. - Melville, NY : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 95:1, s. 323-326
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Tidskriftsartikel (refereegranskat)abstract
- We consider theoretically the use of a room-temperature silicon quantum dot based device for electrometer applications. The low power device includes two split gates that quantize the electronic energy levels in the emitter and collector regions. The base consists of a silicon quantum dot buried in silicon dioxide. The small size of the dotand quantization of the states in the leads combined to allow the device to operate at room temperature. The nonlinear current-voltage characteristics can be significantly altered by small changes to the potential of the split gates. Power dissipation in the device therefore changes with the split gate voltage, and this can be exploited in electrometerapplications. A simple model of the power dissipated when the device is part of a microwave resonant inductor-resistor-capacitor tank circuit suggests that large changes indevice power can be achieved by changing the gate voltage, thereby forming a measurable signal. We also demonstrate that the power dissipation in the device changes as the base width is varied, and that the current through the device increases exponentially with a decrease in base width. (©2004 American Institute of Physics)
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| 9. |
- Kadi, Fawzi, et al.
(författare)
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The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy.
- 2002
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Ingår i: Journal of muscle research and cell motility. - Dordrecht : Springer. - 0142-4319 .- 1573-2657. ; 23:4, s. 335-9
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Tidskriftsartikel (refereegranskat)abstract
- Decreased estrogen production is associated with changes in the skeletal, cardiovascular and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in force production occurs at menopause but the underlying mechanisms are still unknown. The aim of the study was to investigate the effects of ovariectomy on myosin heavy chain (MyHC) composition. Additionally, we studied the effects of physical activity and the combined effects of physical activity and estrogen treatment on MyHC content in ovariectomised (OX) animals. Twenty-five rats were randomly assigned to five different groups: controls, runners, OX, ovariectomised runners and ovariectomised runners receiving estrogen. Exercise consisted of voluntary running for 5 weeks. Two muscles were analysed: m. extensor digitorum longus, EDL, (fast muscle) and m. soleus (slow muscle). MyHC content was analysed on 8% gel electrophoresis. The level of running activity is reduced in OX animals and estrogen administration is associated with the normalisation of the level of physical activity. Ovariectomy induces a shift from fast to slow MyHC isoforms in both the soleus and EDL. When OX animals are allowed to run, alterations in MyHC isoforms are still observed in the EDL but not in the soleus. When physical activity is combined with estrogen treatment no alterations are observed in both muscles. In conclusion, this study shows that ovariectomy induces alterations in the contractile properties of skeletal muscles and that physical activity in combination with estrogen treatment are associated with the maintenance of slow and fast muscle characteristics.
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