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Assessment of mRNA levels for matrix molecules and TGF-B1 in rabbit flexor and peroneus tendons reveals regional differences in steady-state expression

Berglund, Maria, 1975- (author)
Uppsala universitet,Handkirurgi
Wiig, Monica (author)
Uppsala universitet,Handkirurgi
Torstensson, Marie (author)
Uppsala universitet,Handkirurgi
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Reno, Carol (author)
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
Hart, David A. (author)
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
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 (creator_code:org_t)
2016-08-29
2004
English.
In: Journal of Hand Surgery - British and European Volume. - : SAGE Publications. - 0266-7681 .- 1532-2211. ; 29:2, s. 165-169
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This study analysed the differences on a molecular level between two segments of the deep flexor tendon, and compared the intrasynovial flexor tendon with the tendon sheath and the extrasynovial peroneus tendon in a rabbit model. The TRIspin method of RNA extraction was combined with the reverse transcription polymerase chain reaction to assess mRNA levels in the tissue segments. Significant differences were detected for all genes studied. mRNA levels for aggrecan, biglycan and collagen III were significantly higher in the fibrocartilaginous proximal segment of the flexor tendon. Collagen I was higher in the flexor tendon than the sheath and the peroneus tendon, and TGF-beta1 was significantly lower in the peroneus tendon. This study demonstrates differences at the mRNA level between different segments of tendon, indicating that the tendon tissue may be adapted to its environment.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

flexor tendon
proteoglycan
collagen
tendon heterogeneity
Hand surgery
Handkirurgi
Orthopaedics
Ortopedi

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ref (subject category)
art (subject category)

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Berglund, Maria, ...
Wiig, Monica
Torstensson, Mar ...
Reno, Carol
Hart, David A.
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Surgery
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Journal of Hand ...
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Uppsala University

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