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Träfflista för sökning "LAR1:lu ;conttype:(refereed);pers:(Borrebaeck Carl)"

Sökning: LAR1:lu > Refereegranskat > Borrebaeck Carl

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Numrering	Referens	Omslagsbild	Hitta
51.	Borrebaeck, Carl (författare) Identification of disease specific serum biomarkers using recombinant antibody microarrays and directly labelled proteomes 2007 Konferensbidrag (refereegranskat)
52.	Borrebaeck, Carl (författare) Implementing affinity proteomics into the clinic - diagnosis and prediction of metastatic breast cancer 2009 Ingår i: New Biotechnology. - : Elsevier BV. - 1876-4347 .- 1871-6784. ; 25, s. 43-43 Konferensbidrag (refereegranskat)
53.	Borrebaeck, Carl (författare) Improved diagnosis and therapy for mantle cell lymphomas 2007 Konferensbidrag (refereegranskat)
54.	Borrebaeck, Carl (författare) Predictors in Clinical Oncology 2007 Konferensbidrag (refereegranskat)
55.	Borrebaeck, Carl, et al. (författare) Progress in miniaturisation of proteon arrays - a step closer to high-density nanoarrays 2007 Ingår i: Drug Discovery Today. - : Elsevier BV. - 1878-5832 .- 1359-6446. ; 12:19-20, s. 813-819 Forskningsöversikt (refereegranskat)abstract Protein microarrays is a technology with great promise for high-throughput proteomics. Designing high-performance protein microarrays for global proteome analysis has, however, turned out to be challenging. To this end, major efforts are under way to design novel array formats capable of harboring the tremendous range of probes required to target complex proteomes composed of more than 10 000 analytes. By adopting nanotechnology, the first generation of miniaturized nanoarrays has recently emerged, which opens up new avenues for global proteome analysis and disease proteomics. This review describes the progress and key issues in designing miniaturized protein arrays.
56.	Borrebaeck, Carl, et al. (författare) Protein chips based on recombinant antibody fragments: A highly sensitive approach as detected by mass spectrometry 2001 Ingår i: BioTechniques. - 0736-6205. ; 30:5, s. 1126-1126 Tidskriftsartikel (refereegranskat)abstract With the human genome in a first sequence draft and several other genomes being finished this year, the existing information gap between genomics and proteomics is becoming increasingly evident. The analysis of the proteome is, however, much more complicated because the synthesis and structural requirements of functional proteins are different from the easily handled oligonucleotides for which a first analytical breakthrough already has come in the use of DNA chips. In comparison with the DNA microarrays, the protein arrays, or protein chips, offer the distinct possibility of developing a rapid global analysis of the entire proteome. Thus, the concept of comparing proteomic maps of healthy and diseased cells may allow us to understand cell signaling and metabolic pathways and will form a novel base for pharmaceutical companies to develop future therapeutics much more rapidly. This report demonstrates the possibilities of designing protein chips based on specially constructed, small recombinant antibody fragments using nanostructure surfaces with biocompatible characteristics, resulting in sensitive detection in the 600-amol range. The assay readout allows the determination of single or multiple antigen-antibody interactions. Mass identity of the antigens, currently with a resolution of 8000, enables the detection of structural modifications of single proteins.
57.	Borrebaeck, Carl (författare) Protein-microarray developments 2003 Konferensbidrag (refereegranskat)
58.	Borrebaeck, Carl (författare) Protein microarrays for high-throughput proteomics 2004 Konferensbidrag (refereegranskat)
59.	Borrebaeck, Carl, et al. (författare) Recombinant antibodies for the generation of antibody arrays. 2011 Ingår i: Methods in Molecular Biology. - Totowa, NJ : Humana Press. - 1940-6029. ; 785, s. 247-262 Tidskriftsartikel (refereegranskat)abstract Affinity proteomics, mainly represented by antibody microarrays, has in recent years been established as a powerful tool for high-throughput (disease) proteomics. The technology can be used to generate detailed protein expression profiles, or protein maps, of focused set of proteins in crude proteomes and potentially even high-resolution portraits of entire proteomes. The technology provides unique opportunities, for example biomarker discovery, disease diagnostics, patient stratification and monitoring of disease, and taking the next steps toward personalized medicine. However, the process of designing high-performing, high-density antibody micro- and nanoarrays has proven to be challenging, requiring truly cross-disciplinary efforts to be adopted. In this mini-review, we address one of these key technological issues, namely, the choice of probe format, and focus on the use of recombinant antibodies vs. polyclonal and monoclonal antibodies for the generation of antibody arrays.
60.	Borrebaeck, Carl (författare) Recombinant antibody microarrays as a tool to decipher complex disease associated protein signatures 2008 Konferensbidrag (refereegranskat)

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Författare/redaktör: Borrebaeck, Carl (240)Ta bort avgränsningen; Wingren, Christer (104); Lindstedt, Malin (39); Borrebaeck, Carl A K (37); Ingvarsson, Johan (33); Ohlin, Mats (31); visa fler...; Ek, Sara (26); Ellmark, Peter (25); Carlsson, Anders (21); Lundberg, Kristina (11); Larsson, Kristina (10); Furebring, Christina (10); Jerkeman, Mats (9); Greiff, Lennart (9); Carlsson, Roland (9); Dictor, Michael (9); Uhlén, Mathias (8); Jirström, Karin (8); Andreasson, Ulrika (8); Axelsson, Ulrika (8); Malmborg Hager, Ann ... (8); Fernö, Mårten (7); Johansson, Henrik (7); Laurell, Thomas (7); James, Peter (7); Rydén, Lisa (6); Sturfelt, Gunnar (6); Marko-Varga, György (6); Johansson-Lindbom, B ... (6); Högerkorp, Carl-Magn ... (6); Persson, Helena (6); Wahren, Britta (6); Danielsson, Lena (6); Karlsson, Fredrik (5); Olsson, Håkan (5); Baldetorp, Bo (5); Albrekt, Ann-Sofie (5); Nordström, Malin (5); Ohlsson, Mattias (4); Salford, Leif (4); Bjartell, Anders (4); Hansson, Stefan (4); Korsgren, Magnus (4); Johnsson, Per (4); Peterson, Carsten (4); Jansson, Bo (4); Ingvarsson, Sigurdur (4); Broos, Sissela (4); Gustavsson, Elin (4); Persson, Oscar (4); visa färre...

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