SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "swepub ;lar1:(umu);pers:(Stattin Pär);pers:(Sun Jielin);pers:(Isaacs William)"

Sökning: swepub > Umeå universitet > Stattin Pär > Sun Jielin > Isaacs William

  • Resultat 11-12 av 12
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Sun, Jielin, et al. (författare)
  • Sequence variants at 22q13 are associated with prostate cancer risk.
  • 2009
  • Ingår i: Cancer research. - 1538-7445. ; 69:1, s. 10-5
  • Tidskriftsartikel (refereegranskat)abstract
    • To search for genetic variants that are associated with prostate cancer risk in the genome, we combined the data from our genome-wide association study (GWAS) in a population-based case-control study in Sweden with publicly available GWAS data from the Cancer Genetic Markers of Susceptibility (CGEMS) study. We limited the cases to those with aggressive disease in an attempt to identify risk variants that are associated with this most clinically relevant form of the disease. Among the most likely candidate single nucleotide polymorphisms (SNP) identified from the two GWAS, we sequentially confirmed one SNP at 22q13 in two independent study populations: the remaining subjects in Cancer of the Prostate in Sweden and a hospital-based case-control study at Johns Hopkins Hospital. Association of aggressive prostate cancer with the SNP at 22q13 was also observed in the publicly available data of four additional study populations from the second stage of the CGEMS study. In all seven study populations examined, the frequency of allele "C" of rs9623117 at 22q13 was consistently higher in aggressive cases than in controls. The combined allelic test was highly significant, with P = 5.0 x 10(-7). The odds ratio (OR) of allele C for aggressive prostate cancer was estimated to be 1.18 [95% confidence interval (95% CI), 1.11-1.26]. However, the SNP was also associated with nonaggressive prostate cancer, with an estimated OR of 1.11 (95% CI, 1.04-1.19; P = 0.004). The risk-associated variants are located within the genomic region of TNRC6B, a gene involved in miRNA-mediated mRNA degradation. Additional studies are warranted to further confirm the association.
  •  
12.
  • Yeager, Meredith, et al. (författare)
  • Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
  • 2009
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:10, s. 1055-7
  • Tidskriftsartikel (refereegranskat)abstract
    • We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-12 av 12
Typ av publikation
tidskriftsartikel (12)
Typ av innehåll
refereegranskat (11)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Wiklund, Fredrik (12)
Xu, Jianfeng (12)
Isaacs, William B (9)
Grönberg, Henrik (8)
Hsu, Fang Chi (8)
visa fler...
Duggan, David (8)
Wiley, Kathleen E (7)
Zhu, Yi (6)
Adami, Hans Olov (6)
Carpten, John D (5)
Isaacs, Sarah D (5)
Adolfsson, Jan (4)
Gronberg, Henrik (4)
Walsh, Patrick C (4)
Kaaks, Rudolf (2)
Riboli, Elio (2)
Johansson, Jan-Erik (2)
Schumacher, Fredrick ... (2)
Chanock, Stephen J (2)
Albanes, Demetrius (2)
Cancel-Tassin, Geral ... (2)
Hoover, Robert N. (2)
Orr, Nick (2)
Kraft, Peter (2)
Chatterjee, Nilanjan (2)
Andriole, Gerald L (2)
Diver, W Ryan (2)
Feigelson, Heather S ... (2)
Le Marchand, Loïc (2)
Thomas, Gilles (2)
Thun, Michael J (2)
Virtamo, Jarmo (2)
Yeager, Meredith (2)
Hunter, David J (2)
Hayes, Richard B (2)
Yu, Kai (2)
Hutchinson, Amy (2)
Jacobs, Kevin B (2)
Bälter, Katarina (2)
Trent, Jeffrey M. (2)
Hveem, Kristian (2)
Valeri, Antoine (2)
Cussenot, Olivier (2)
Lindström, Sara (2)
Wang, Zhaoming (2)
Weinstein, Stephanie (2)
Wacholder, Sholom (2)
Crawford, E David (2)
Henderson, Brian (2)
visa färre...
Lärosäte
Karolinska Institutet (6)
Mälardalens universitet (2)
Örebro universitet (2)
Göteborgs universitet (1)
Lunds universitet (1)
Språk
Engelska (12)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy