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Sökning: WFRF:(von Schoultz B)

  • Resultat 31-40 av 108
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  • Cline, JM, et al. (författare)
  • Assessment of hormonally active agents in the reproductive tract of female nonhuman primates
  • 2001
  • Ingår i: Toxicologic pathology. - : SAGE Publications. - 0192-6233 .- 1533-1601. ; 29:1, s. 84-90
  • Tidskriftsartikel (refereegranskat)abstract
    • Using the ovariectomized macaque model of postmenopausal women's health, we investigated the effects of long-term treatments (5 weeks—3 years) with estradiol, conjugated equine estrogens (CEE), esterified estrogens, progestins such as medroxyprogesterone acetate (MPA) and nomegestrol acetate, CEE + MPA, tamoxifen, soybean phytoestrogens (SPEs), a variety of putative selective estrogen receptor modulators (SERMs), and androgens. Agents tested were selected on the basis of beneficial effects on arteries and/ or bone. Doses were scaled on a caloric or serum-concentration basis to approximate human clinical doses. We evaluated endometrial and mammary gland histopathology and morphometry and used immunohistochemistry to evaluate cell proliferation and expression of estrogen receptor alpha and progesterone receptor (PR). Both estradiol and CEE induced endometrial hyperplasia. MPA antagonized epithelial proliferation induced by CEE in endometrium and induced pseudodecidual stromal hyperplasia in some animals. Tamoxifen induced endometrial polyps, cystic hyperplasia, stromal fi brosis, and PR expression but not Ki-67 expression. SPEs were not estrogenic at dietary doses and antagonized estrogen-induced proliferation in the endometrium and breast. Nandrolone induced mucometra and an adenomyosis-like change. The potential SERM 17 alpha dihydroequilenin did not have uterotrophic or mammotrophic effects. In general, experimental findings in macaques have been predictive of outcomes in human clinical trials of the same agents.
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  • Conner, P, et al. (författare)
  • Breast cancer and hormonal therapy
  • 2008
  • Ingår i: Clinical obstetrics and gynecology. - 1532-5520. ; 51:3, s. 592-606
  • Tidskriftsartikel (refereegranskat)
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  • Darj, Elisabeth, et al. (författare)
  • Liver metabolism during treatment with estradiol and progesterone
  • 1993
  • Ingår i: Gynecological Endocrinology. - : Informa UK Limited. - 0951-3590 .- 1473-0766. ; 7:2, s. 111-114
  • Tidskriftsartikel (refereegranskat)abstract
    • Serum concentrations of sex hormone-binding globulin (SHBG), corticosteroid binding globulin (CBG), ceruloplasmin, lipoprotein A and liver enzymes were measured in 30 postmenopausal women treated with 2 mg micronized 17 beta-estradiol daily and micronized progesterone orally in doses of 50, 100 and 200 mg daily, as progestogen supplementation. The treatment lasted for 4 months. The serum levels of SHBG and CBG increased during treatment and a weak association between progesterone dosage and CBG was observed. Levels of lipoprotein A and liver enzymes did not change. It is concluded that micronized natural progesterone is an attractive means of progesterone supplementation in postmenopausal hormone replacement therapy without any liver-related side-effects.
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  • Resultat 31-40 av 108

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