| 21. |
- Dezsi, Livia, et al.
(författare)
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Inclusion body myositis - a rarely recognized disorder
- 2013
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Ingår i: Ideggyogyaszati Szemle - Clinical Neuroscience. - Budapest, Hungary : Literatura Medica Kiado. - 0019-1442. ; 66:3-4, s. 89-101
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Forskningsöversikt (refereegranskat)abstract
- Inclusion body myositis is the most common disabling inflammatory myopathy in the elderly. It is more frequent in men and after the age of 50 years. Inflammatory and degenerative features coexist. There is a T-cell mediated autoimmunity driven by in situ clonally expanded cytotoxic CD8-positive T-cells invading non-necrotic muscle fibres expressing MHC-I antigen. The hallmarks of degeneration are the deposition of protein aggregates and the formation of vesicles. The course of the disease is slow and the diagnosis is usually set after several years. The muscle weakness and wasting is assymetric, affecting predominantly distal muscles of the upper extremity and proximal muscles of the legs. The signs and clinical course can be characteristic, but the diagnosis is established by muscle biopsy. less thanbrgreater than less thanbrgreater thanThere is currently no evidence based effective treatment for sIBM. Prednisone, azathioprine, methotrexate, cyclosporine and IFN-beta failed. Oxandrolon did not improve symptoms. Treatment with intravenous immunglobuline (IVIG) induced in some patients a transient improvement of swallowing and of muscle strenght, but the overall study results were negative. less thanbrgreater than less thanbrgreater thanA T-cell depleting monoclonal antibody (alemtuzumab), in a small uncontrolled study slowed down disease progression for a six-month period. Repeated muscle biopsies showed the reduction of T-cells in the muscle and the suppression of some degeneration associated molecules. An effective therapeutic mean should act on both aspects of the pathomechanism, on the inflammatory and the degenerative processes as well.
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| 22. |
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| 24. |
- Erós, N, et al.
(författare)
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[New aspects in the classification of cutaneous lymphomas]. : Szemléletváltozás a kután lymphomák klasszifikációjában.
- 2001
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Ingår i: Orvosi hetilap. - 0030-6002. ; 142:8, s. 393-8
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Tidskriftsartikel (refereegranskat)abstract
- Authors discuss the classification of primary cutaneous lymphomas created by the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer (EORTC) in 1996, which is based on the clinical, histological, immunohistochemical and genetic features of cutaneous lymphomas. Unlike the previous histologic classifications it contains well-defined disease entities characterized by their clinical and histological picture, clinical outcome, behaviour and therapeutic response. This classification does not use the term of low grade or high grade lymphoma, but introduces the indolent, aggressive and provisional subgroups in the T-cell lymphomas, and indolent, intermediate and provisional subgroups in the B-cell group. Authors demonstrate the EORTC classification by their own cases calling the attention to the clinical and therapeutic difference between nodal and extranodal lymphomas, and discuss the up-to-date therapeutic possibilities.
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| 26. |
- Éva, Hadházi, et al.
(författare)
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Elozetes eredmények egy magyar mintán kidolgozott Intrauterin Kapcsolati Kérdoív méréses tapasztalatairól-pilot study
- 2017
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Ingår i: Mentalhigiene es Pszichoszomatika. - : Akademiai Kiado Zrt.. - 1419-8126 .- 1786-3759. ; 18:3, s. 263-300
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Tidskriftsartikel (refereegranskat)abstract
- Background: The effects of "maternal environment" on fetal development have been studied since the eighties, but the results regarding the features which influence mother-fetus relationship are inconsistent. Aim: To develop a mother-fetus relationship assessment scale on a Hungarian sample, and to reveal the factors that determine mother-fetus bonding. Method: 114 pregnant women, between 15 and 38 weeks of gestational age, filled out the Intrauterine Relationship Questionnaire, the Hungarian version of Maternal Fetal Attachment Scale, Intimate Bond Measurement and Parental Bonding Instrument. Results: our 28 items Intrauterine Relationship Questionnaire's (IURQ) factor structure indicators proved to remain below the expectations (RMSEA =. 08, χ 2/df = 1.645, NFI =. 85, CFI =. 87). The eight subscales' Cronbach's alphas are between. 56 and. 93. With exploratory factor analysis we managed to develop a shortened version model (IURQ-S), with better psychometric characteristics, which contains 12 items and 3 subscales (RMSEA =. 08, χ 2/df = 1.660, NFI =. 95, CFI =. 96). The internal consistency of IURQ-S is high, Cronbach's alphas range from. 81 to. 93. For further analyses we used the IURQ-S model. Our questionnaire correlate with MFAS-HU but their dimensions are not entirely overlapping. In accordance with international experiences we found that a mother reaches significantly higher scores on the mother-fetus relationship scale, if she can be characterized with any of the following: married, has high contribution to family income, no previous experience of miscarriage, born in natural way, without any intervention, definitely knows or definitely does not know the fetus' sex. The time of the pregnancy had no substantial effect, neither had the educational background of the mother or whether the pregnancy was planned. The method of conception, the number of children born previously and the fetal movement did not prove to be decisive either. Fetal attachment correlated with partnership intimacy: higher mother-fetus attachment scores were found with higher perceived care and lower perceived control. The mother's own parental bonding, her perceived maternal and paternal love was found to be in positive correlation with her attachment to her fetus. Conclusions: The questionnaire reliability is promising, but further validity examinations are needed in a larger, more heterogeneous sample. The results have drawn our attention to the importance of parental bonding and perceived partner care during pregnancy, and can help prevention of early attachment disfunction.
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| 27. |
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| 29. |
- Farkas, Zita
(författare)
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Az abortusz szigorítása, mint nemzeti emnacipáció
- 2012
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Ingår i: Társadalmi Nemek Tudománya: Interdiszciplináris eFolyóirat . [Interdisciplinary eJournal of Gender Studies]. - 2062-7084. ; 2:2, s. 113-131
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Tidskriftsartikel (refereegranskat)
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| 30. |
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