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  • Result 14751-14760 of 39774
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14751.
  • He, T., et al. (author)
  • The role of colonic metabolism in lactose intolerance
  • 2008
  • In: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 38:8, s. 541-547
  • Research review (peer-reviewed)abstract
    • Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fermentation metabolites and how these processes would play a role in the pathophysiology of lactose intolerance. We suggest that the balance between the removal and production rate of osmotic-active components (lactose, and intermediate metabolites, e.g. lactate, succinate, etc.) in the colon is a key factor in the development of symptoms. The involvement of the colon may provide the basis for designing new targeted strategies for dietary and clinical management of lactose intolerance.
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14752.
  • Heap, Graham A., et al. (author)
  • Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease
  • 2016
  • In: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 10:2, s. 149-158
  • Journal article (peer-reviewed)abstract
    • Background and Aims: Nephrotoxicity is a rare idiosyncratic reaction to 5-aminosalicylate (5-ASA) therapies. The aims of this study were to describe the clinical features of this complication and identify clinically useful genetic markers so that these drugs can be avoided or so that monitoring can be intensified in high-risk patients.Methods: Inflammatory bowel disease patients were recruited from 89 sites around the world. Inclusion criteria included normal renal function prior to commencing 5-ASA, >= 50% rise in creatinine any time after starting 5-ASA, and physician opinion implicating 5-ASA strong enough to justify drug withdrawal. An adjudication panel identified definite and probable cases from structured case report forms. A genome-wide association study was then undertaken with these cases and 4109 disease controls.Results: After adjudication, 151 cases of 5-ASA-induced nephrotoxicity were identified. Sixty-eight percent of cases were males, with nephrotoxicity occurring at a median age of 39.4 years (range 6-79 years). The median time for development of renal injury after commencing 5-ASA was 3.0 years (95% confidence interval [CI] 2.3-3.7). Only 30% of cases recovered completely after drug withdrawal, with 15 patients requiring permanent renal replacement therapy. A genome-wide association study identified a suggestive association in the HLA region (p = 1 x 10(-7)) with 5-ASA-induced nephrotoxicity. A sub-group analysis of patients who had a renal biopsy demonstrating interstitial nephritis (n = 55) significantly strengthened this association (p = 4 x 10(-9), odds ratio 3.1).Conclusions: This is the largest and most detailed study of 5-ASA-induced nephrotoxicity to date. It highlights the morbidity associated with this condition and identifies for the first time a significant genetic predisposition to drug-induced renal injury.
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14753.
  • Heap, Graham A., et al. (author)
  • HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
  • 2014
  • In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:10, s. 1131-1134
  • Journal article (peer-reviewed)abstract
    • Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 x 10(-16)). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the H LA region identified association with the HLA-DQA1*02:01-HLA-DRB1*07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.
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14754.
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14755.
  • Hearn, Jeff, 1947- (author)
  • ‘A life of violence’ : Some theoretical/political/policy/personal accountings on ‘masculinities’ and ‘intimate partner violence’
  • 2020
  • In: Men, Masculinities and Intimate Partner Violence. - London : Routledge. - 9780367234898
  • Book chapter (peer-reviewed)abstract
    • Reflecting on “a life of violence”, I had no idea that this issue would be such a key thread, provocation and problematic in most of my academic life, albeit in many different ways. Much, though not all, of this work has been within academic framework of Critical Studies on Men and Masculinities (CSMM), as a sub-field within Gender Studies, alongside policy development and profeminist activism. Indeed, I came to realise fairly early on if one is interested in studying, and changing, men and masculinities, whether in research, politics or everyday practice, it is really very difficult to do this without giving attention to violence and anti-violence.  In this chapter, I suggest, as invited by the editors, some theoretical/political/policy/reflexive personal accountings of these various engagements with men, masculinities and violences, especially in terms of bringing together CSMM, Violence Studies, Sexuality Studies, Organization Studies, Social Policy, and Sociology, along with my place and positioning, some contributions, and some difficulties. This theoretical/political/policy/reflexive personal positioning reflects a broader ontoepistemological question: the relation of the personal is political is theoretical is work.
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14756.
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14757.
  • Hearn, Jeff (author)
  • A multi-faceted power analysis of mens violence to known women: from hegemonic masculinity to the hegemony of men
  • 2012
  • In: Sociological Review. - : Wiley-Blackwell. - 0038-0261 .- 1467-954X. ; 60:4, s. 589-610
  • Journal article (peer-reviewed)abstract
    • This article presents a multi-faceted power analysis of mens violence to known women, by way of assessing two main perspectives on research in men and masculinities: first, that founded on hegemonic masculinity, and, second, that based on the hegemony of men. Each perspective is interrogated in terms of understandings of mens violence to known women. These approaches are articulated in relation to empirical research, and conceptual and theoretical analysis. Thus this article addresses to what extent hegemonic masculinity and the hegemony of men, respectively, are useful concepts for explaining and engaging with mens violence to known women? The article concludes with discussion of more general implications of this analysis.
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14758.
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14759.
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14760.
  • Hearn, Jeff, 1947-, et al. (author)
  • Age at Work : Ambiguous Boundaries of Organizations, Organizing and Ageing
  • 2020. - 1
  • Book (peer-reviewed)abstract
    • Age at Work explores the myriad ways in which ‘age’ is at ‘work’ across society, organizations and workplaces, with special focus on organizations, their boundaries, and marginalizing processes around age and ageism in and across these spaces.The book examines:how society operates in and through age, and how this informs the very existence of organizations;age-organization regimes, age-organization boundaries, and the relationship between organizations and death, and post-death;the importance of memory, forgetting and rememorizing in re-thinking the authors’ and others’ earlier work; andtensions between seeing age in terms of later life and seeing age as pervasive social relations.Enriched with insights from the authors’ lived experiences, Age at Work is a major and timely intervention in studies of age, work, care and organizations. Ideal for students of Sociology, Organizations and Management, Social Policy, Gerontology, Health and Social Care, and Social Work.
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  • Result 14751-14760 of 39774
Type of publication
journal article (21631)
conference paper (6906)
book chapter (3930)
other publication (1673)
reports (1326)
doctoral thesis (1322)
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research review (1082)
book (703)
editorial collection (453)
review (417)
licentiate thesis (142)
artistic work (127)
editorial proceedings (82)
patent (9)
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Type of content
peer-reviewed (26998)
other academic/artistic (10885)
pop. science, debate, etc. (1873)
Author/Editor
Larsson, Henrik, 197 ... (581)
Ludvigsson, Jonas F. ... (429)
Edvardsson, Bo, 1944 ... (381)
Orešič, Matej, 1967- (349)
Hearn, Jeff, 1947- (318)
Unemo, Magnus, 1970- (309)
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Halfvarson, Jonas, 1 ... (308)
Lichtenstein, Paul (298)
Danielsson-Tham, Mar ... (298)
Ljungqvist, Olle, 19 ... (291)
Cao, Yang, Associate ... (247)
Möller, Claes, 1950- (246)
Montgomery, Scott, 1 ... (245)
Öberg, Christina, 19 ... (233)
Yngve, Agneta, 1953- (202)
Hyötyläinen, Tuulia, ... (195)
Fröbert, Ole, 1964- (186)
Fall, Katja, 1971- (179)
Ervo, Laura, 1966- (179)
Linton, Steven J., 1 ... (177)
Lilienthal, Achim J. ... (176)
Persson, Annina H., ... (171)
Quennerstedt, Mikael ... (170)
Kristoffersson, Eleo ... (164)
Bagga-Gupta, Sangeet ... (163)
Grönlund, Åke, 1954- (161)
Andershed, Henrik, 1 ... (161)
von Euler, Mia, 1967 ... (157)
Repsilber, Dirk, 197 ... (156)
Blomberg, Karin, 197 ... (155)
Englund, Tomas, 1946 ... (154)
Loutfi, Amy, 1978- (149)
Tuvblad, Catherine, ... (148)
De Raedt, Luc, 1964- (146)
Söderquist, Bo, 1955 ... (144)
Eriksson, Mats, Prof ... (144)
Büki, Andras, 1966- (138)
Wang, Thanh, 1979- (136)
Magnuson, Anders (133)
Jendle, Johan, 1963- (132)
D'Onofrio, Brian M. (132)
Parodis, Ioannis, 19 ... (129)
Saffiotti, Alessandr ... (129)
Bhatt, Mehul, Profes ... (125)
Stattin, Håkan (125)
Tham, Wilhelm, 1951- (125)
Ericsson, Elisabeth, ... (124)
Bejerot, Susanne, 19 ... (123)
Barker-Ruchti, Natal ... (123)
Yeung, Leo W. Y., 19 ... (122)
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University
Örebro University  (39774)Undo refine
Karolinska Institutet (5070)
Uppsala University (2937)
Linköping University (2238)
University of Gothenburg (1619)
Umeå University (1285)
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Lund University (1205)
Stockholm University (880)
Karlstad University (803)
Linnaeus University (781)
Högskolan Dalarna (778)
Jönköping University (642)
Mälardalen University (580)
Mid Sweden University (335)
University of Gävle (333)
Södertörn University (308)
Royal Institute of Technology (289)
The Swedish School of Sport and Health Sciences (283)
University of Skövde (246)
Malmö University (184)
Marie Cederschiöld högskola (181)
Swedish University of Agricultural Sciences (177)
Chalmers University of Technology (166)
Luleå University of Technology (150)
Halmstad University (123)
University of Borås (97)
Kristianstad University College (79)
RISE (74)
Red Cross University College (74)
Stockholm School of Economics (70)
Blekinge Institute of Technology (64)
VTI - The Swedish National Road and Transport Research Institute (53)
University West (50)
Sophiahemmet University College (44)
Royal College of Music (44)
University College of Arts, Crafts and Design (25)
Swedish National Defence College (25)
Swedish Environmental Protection Agency (9)
Swedish Museum of Natural History (9)
IVL Swedish Environmental Research Institute (4)
The Nordic Africa Institute (1)
Stockholm University of the Arts (1)
Swedish Agency for Marine and Water Management (1)
University College Stockholm (1)
The Institute for Language and Folklore (1)
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Language
English (32145)
Swedish (6928)
German (130)
Finnish (114)
Norwegian (83)
Spanish (70)
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Polish (43)
Danish (41)
French (40)
Italian (38)
Hungarian (37)
Portuguese (24)
Ukranian (18)
Persian (8)
Chinese (7)
Turkish (6)
Russian (5)
Arabic (4)
Japanese (4)
Greek, Modern (4)
Undefined language (3)
Dutch (3)
Icelandic (3)
Czech (3)
Croatian (3)
Estonian (2)
Slovenian (2)
Korean (2)
Greek, Ancient (1)
Lithuanian (1)
Catalan (1)
Bokmål (1)
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Research subject (UKÄ/SCB)
Social Sciences (16027)
Medical and Health Sciences (15419)
Natural sciences (5970)
Humanities (2936)
Engineering and Technology (1427)
Agricultural Sciences (469)

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