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Sökning: LAR1:gu > Göteborgs universitet

  • Resultat 83391-83400 av 162872
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83391.
  • Lager, Susanne, 1978, et al. (författare)
  • Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4
  • 2013
  • Ingår i: Journal of Lipid Research. - 0022-2275. ; 54:3, s. 725-733
  • Tidskriftsartikel (refereegranskat)abstract
    • Obese women have an increased risk to deliver large babies. However, the mechanisms underlying fetal overgrowth in these pregnancies are not well understood. Obese pregnant women typically have elevated circulating lipid levels. We tested the hypothesis that fatty acids stimulate placental amino acid transport, mediated via toll-like receptor 4 (TLR4) and mammalian target of rapamycin (mTOR) signaling pathways. Circulating NEFA levels and placental TLR4 expression were assessed in women with varying prepregnancy body mass index (BMI). The effects of oleic acid on system A and system L amino acid transport, and on the activation of the mTOR (4EBP1, S6K1, rpS6), TLR4 (IĸBɑ, JNK, p38 MAPK), and STAT3 signaling pathways were determined in cultured primary human trophoblast cells. Maternal circulating NEFAs (n = 33), but not placental TLR4 mRNA expression (n = 16), correlated positively with BMI (P < 0.05). Oleic acid increased trophoblast JNK and STAT3 phosphorylation (P < 0.05), whereas mTOR activity was unaffected. Furthermore, oleic acid doubled trophoblast system A activity (P < 0.05), without affecting system L activity. siRNA-mediated silencing of TLR4 expression prevented the stimulatory effect of oleic acid on system A activity. Our data suggest that maternal fatty acids can increase placental nutrient transport via TLR4, thereby potentially affecting fetal growth.
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83392.
  • Lager, Susanne, 1978, et al. (författare)
  • Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
  • 2011
  • Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 152:4, s. 1336-46
  • Tidskriftsartikel (refereegranskat)abstract
    • The perinatal environment appears important in establishing metabolic phenotypes in adulthood. Mice deficient in IL-6 (IL-6(-/-)) tend to develop mature-onset obesity, but it is unknown whether perinatal exposure to IL-6 produced by the dam influences the metabolism of adult offspring. To address this issue, we monitored IL-6(-/-) offspring of IL-6(-/-) or IL-6(+/-) dams, as well as wild-type (WT) mice. At adult age, IL-6(-/-) mice weighed significantly more and had more body fat than WT mice, regardless of maternal genotype, and had lower insulin sensitivity. This phenotype was more pronounced in IL-6(-/-) offspring of IL-6(-/-) dams, because they gained weight significantly faster than IL-6(-/-) offspring of IL-6(+/-) dams and had more body fat and higher serum leptin levels at an earlier age. The leptin content was 2-fold higher in milk from IL-6(-/-) than WT dams. However, cross-fostering IL-6(-/-) mice with WT dams did not alter body weight, body composition, or adipocyte size at adult age compared with IL-6(-/-) mice fostered by IL-6(-/-) dams. Conversely, WT mice fostered by IL-6(-/-) dams weighed significantly more than those fostered by WT dams and had more body fat, larger adipocytes, and altered hypothalamic gene expression. We conclude that body fat of adult mice can be increased by perinatal exposure to factors affected by lack of maternal IL-6.
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83393.
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83394.
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83395.
  • Lager, Torbjörn, 1959, et al. (författare)
  • Developing Natural Language Enabled Games in (Extended) SCXML
  • 2007
  • Ingår i: Proceedings from the International Symposium on Intelligence Techniques in Computer Games and Simulations (Pre-GAMEON-ASIA and Pre- ASTEC), Shiga, Japan, March 1-3..
  • Konferensbidrag (refereegranskat)
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83396.
  • Lager, Torbjörn, 1959, et al. (författare)
  • Exploring the Web of Coined Catchy Phrases
  • 2012
  • Ingår i: Proceedings of WWW2012: Web Science Track.
  • Konferensbidrag (refereegranskat)abstract
    • We employ a method inspired by corpus linguistics to illustrate the complexity and multifacetedness of the Web by extracting phrases about the Web from the Web itself. The phrases are divided into semantic categories and analysed with regards to their semantic content and rhetorical functions. We argue that the extracted phrases simultaneously have descriptive content and function as names. We also argue that they are used as rhetorical tools by actors from different groups in society involved in developing the Web, which is why we suggest that they need further attention by scholars interested in Web Science and linguistics.
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83397.
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83398.
  • Lager, Torbjörn, 1959 (författare)
  • Intro to Web Prolog for Erlangers
  • 2019
  • Ingår i: Proceedings of the 18th ACM SIGPLAN International Workshop on Erlang (Erlang ’19), August 18, 2019, Berlin, Germany.. - New York, NY, USA : ACM Press. - 9781450368100
  • Konferensbidrag (refereegranskat)abstract
    • We describe a programming language called Web Prolog. We think of it as a web programming language, or, more specifically, as a web logic programming language. The language is based on Prolog, with a good pinch of Erlang added. We stay close to traditional Prolog, so close that the vast majority of programs in Prolog textbooks will run without modification. Towards Erlang we are less faithful, picking only features we regard as useful in a web programming language, e.g. features that support concurrency, distribution and intra-process communication. In particular, we borrow features that make Erlang into an actor programming language, and on top of these we define the concept of a pengine – a programming abstraction in the form of a special kind of actor which closely mirrors the behaviour of a Prolog top-level. On top of the pengine abstraction we develop a notion of non-deterministic RPC and the concept of the Prolog Web.
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83399.
  • Lager, Torbjörn, 1959, et al. (författare)
  • Part of Speech Tagging from a Logical Point of View
  • 2001
  • Ingår i: In de Groote, P., Morrill, G., Retoré, C. (eds.) Logical Aspects of Computational Linguistics. Springer-Verlag, Lecture Notes in Artificial Intelligence. VOL. 2099:212-227.
  • Konferensbidrag (refereegranskat)
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83400.
  • Lager, Torbjörn, 1959, et al. (författare)
  • Pengines: Web Logic Programming Made Easy
  • 2014
  • Ingår i: Theory and Practice of Logic Programming. - 1471-0684 .- 1475-3081. ; 14:4-5, s. 539-552
  • Tidskriftsartikel (refereegranskat)abstract
    • When developing a (web) interface for a deductive database, functionality required by the client is provided by means of HTTP handlers that wrap the logical data access predicates. These handlers are responsible for converting between client and server data representations and typically include options for paginating results. Designing the web accessible API is difficult because it is hard to predict the exact requirements of clients. Pengines changes this picture. The client provides a Prolog program that selects the required data by accessing the logical API of the server. The pengine infrastructure provides general mechanisms for converting Prolog data and handling Prolog non-determinism. The Pengines library is small (2000 lines Prolog, 150 lines JavaScript). It greatly simplifies defining an AJAX based client for a Prolog program and provides non-deterministic RPC between Prolog processes as well as interaction with Prolog engines similar to Paul Tarau's engines. Pengines are available as a standard package for SWI-Prolog 7.
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