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- Behboudi, Afrouz, 1967, et al.
(författare)
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Detailed chromosomal and radiation hybrid mapping in the proximal part of rat Chromosome 10 and gene order comparison with mouse and human.
- 2002
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Ingår i: Mammalian genome : official journal of the International Mammalian Genome Society. - : Springer Science and Business Media LLC. - 0938-8990 .- 1432-1777. ; 13:6, s. 302-9
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Tidskriftsartikel (refereegranskat)abstract
- The rat provides valuable and sometimes unique models of human complex diseases. To fully exploit the rat models in biomedical research, it is important to have access to detailed knowledge of the rat genome organization as well as its relation to the human genome. Rat Chromosome 10 (RNO10) harbors several important cancer-related genes. Deletions in the proximal part of RNO10 were repeatedly found in a rat model for endometrial cancer. To identify functional and positional candidate genes in the affected region, we used radiation hybrid (RH) mapping and single- and dual-color fluorescence in situ hybridization (FISH) techniques to construct a detailed chromosomal map of the proximal part of RNO10. The regional localization of 14 genes, most of them cancer-related ( Grin2a, Gspt1, Crebbp, Gfer, Tsc2, Tpsb1, Il9r, Il4, Irf1, Csf2, Sparc, Tp53, Thra1, Gh1), and of five microsatellite markers ( D10Mit10, D10Rat42, D10Rat50, D10Rat72, and D10Rat165) was determined on RNO10. For a fifteenth gene, Ppm1b, which had previously been assigned to RNO10, the map position was corrected to RNO6q12-q13.
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| 2. |
- Behboudi, Afrouz, 1967, et al.
(författare)
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Evolutionary aspects of the genomic organization of rat chromosome 10.
- 2002
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Ingår i: Cytogenetic and genome research. - : S. Karger. - 1424-8581 .- 1424-859X. ; 96:1-4, s. 52-9
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Tidskriftsartikel (refereegranskat)abstract
- Using FISH and RH mapping a chromosomal map of rat chromosome 10 (RNO10) was constructed. Our mapping data were complemented by other published data and the final map was compared to maps of mouse and human chromosomes. RNO10 contained segments homologous to mouse chromosomes (MMU) 11, 16 and 17, with evolutionary breakpoints between the three segments situated in the proximal part of RNO10. Near one of these breakpoints (between MMU17 and 11) we found evidence for an inversion ancestral to the mouse that was not ancestral to the condition in the rat. Within each of the chromosome segments identified, the gene order appeared to be largely conserved. This conservation was particularly clear in the long MMU11-homologous segment. RNO10 also contained segments homologous to three human chromosomes (HSA5, 16, 17). However, within each segment of conserved synteny were signs of more extensive rearrangements. At least 13 different evolutionary breakpoints were indicated in the rat-human comparison. In contrast to what was found between rat and mouse, the rat-human evolutionary breaks were distributed along the entire length of RNO10.
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| 3. |
- Hammarlund, Kina, et al.
(författare)
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The lived experience of genital warts : The Swedish example
- 2004
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Ingår i: Health Care for Women International. - : Routledge. - 0739-9332 .- 1096-4665. ; 25:5, s. 489-502
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Tidskriftsartikel (refereegranskat)abstract
- Our aim in this study was to analyze and describe young Swedish women's experiences of living with genital warts. Interviews with 10 young women, aged 16-21 years, were interpreted within a lifeworld hermeneutic tradition. The women experience themselves as victims of a disgusting disease. Furthermore, they appear to disregard the fact that their own lifestyles could be a risk factor for contracting venereal infections. On the other hand they get to know their bodies better after the gynecological examinations where the treatment begins. Their loss of innocence is considerable; thus it seems fair to compare this experience with earlier epochs' ideas about loss of virginity due to the first intercourse. Consequently the young women also start looking at themselves as adults, and they take responsibility for the consequences of their sexuality.
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| 4. |
- Johansson, Annelie, et al.
(författare)
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Living with experiences following a myocardial infarction
- 2003
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Ingår i: European Journal of Cardiovascular Nursing. - : Elsevier. - 1474-5151 .- 1873-1953. ; 2:3, s. 229-336
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Tidskriftsartikel (refereegranskat)abstract
- Coronary heart disease is a major cause of sudden death and morbidity in the developed world, as well as a cause of great suffering. Research within this area has primarily focused symptoms, risk factors and treatment. The aim of this paper was to explore women's experiences following a myocardial infarction (MI). Eight women were interviewed; the interviews were audiotaped and transcribed into text and analysed using a phenomenological approach. To explore the meaning that is experienced in the lived world of the patient a method of reflective lifeworld research, based upon phenomenological epistemology has been used. The results indicate that the body is vital for the women in their lifeworlds. After a MI the patient's natural and unreflective relationship with the body and the lived world is interrupted. Uncertainty about life and death as well as the body is experienced as a suffering in the women's lifeworlds. In relation to this, the women's existence is characterised by an uncertainty and a loss of context. It is through reconciliation with their bodies and their illnesses that the women can achieve a sense of well-being and harmony in life. In that process the women can re-establish a natural relationship with their bodies and lifeworlds.
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| 5. |
- Orlenius, Kennert
(författare)
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Gårdagens elever utbildar morgondagens vuxna
- 2004
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Ingår i: Etik i princip och praktik. En antologi om yrkesetik. - Stockholm : Lärarförbundet & Lärarnas Riksförbund. - 918509689X ; , s. 17-25
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Orlenius, Kennert
(författare)
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Individuality and Solidarity : the Role and Goals in Religious Education
- 2004
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Ingår i: Towards a European Perspective on Religious Education. - Skellefteå : Artos och Norma förlag. - 9175802767 ; , s. 157-165
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- When I was born, in 1949, teachers in Sweden were not allowed to teach religion if they did not belong to the Swedish Lutheran Church.1 The name of the subject in school was ‘Christianity’ and religious education was also mainly about Christianity. Religion was in fact seen as a guarantee for security and stability. The society at that time, about fifty years ago, had changed from an agricultural society to an industrial one. This required a disciplined, specialized and rational worker. But during the last fifty years the economy and working life have gone through extensive changes. Nowadays only about 15% are employed in the manufacturing industry in Sweden and there is an increasing demand for a reflective, enterprising human being with power of initiative and personal accountability. As a logical consequence the society sometimes designates as a ‘K-society’ with knowledge, competence, competition, communication and creativity in focus (all words in Swedish being spelled with‘k’ as the first letter)
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