| 66851. |
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| 66852. |
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| 66853. |
- Hillbom, Niklas
(författare)
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The Knossos game board
- 2004
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Ingår i: OpAth. ; 29, s. 39-71
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Tidskriftsartikel (refereegranskat)
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| 66854. |
- Hillen, T., et al.
(författare)
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Birth-jump processes and application to forest fire spotting
- 2015
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Ingår i: Journal of Biological Dynamics. - : Informa UK Limited. - 1751-3766 .- 1751-3758. ; 9, s. 104-127
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Tidskriftsartikel (refereegranskat)abstract
- Birth-jump models are designed to describe population models for which growth and spatial spread cannot be decoupled. A birth-jump model is a nonlinear integro-differential equation. We present two different derivations of this equation, one based on a random walk approach and the other based on a two-compartmental reaction-diffusion model. In the case that the redistribution kernels are highly concentrated, we show that the integro-differential equation can be approximated by a reaction-diffusion equation, in which the proliferation rate contributes to both the diffusion term and the reaction term. We completely solve the corresponding critical domain size problem and the minimal wave speed problem. Birth-jump models can be applied in many areas in mathematical biology. We highlight an application of our results in the context of forest fire spread through spotting. We show that spotting increases the invasion speed of a forest fire front.
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| 66855. |
- Hiller, Adriana Maria
(författare)
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5 frågor till Adriana - Maria Hiller
- 2017
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Ingår i: Lakartidningen. - 0023-7205. ; 114:40, s. 1631-1631
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Tidskriftsartikel (refereegranskat)abstract
- Adriana-Maria Hiller, ST-läkare vid lung- och allergikliniken, Skånes universitetssjukhus, är en av författarna till en artikel om veteberoende ansträngningsutlöst anafylaxi.
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| 66856. |
- Hiller, Adriana-Maria, et al.
(författare)
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Decline in FEV1 and hospitalized exacerbations in individuals with severe alpha-1 antitrypsin deficiency
- 2019
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Ingår i: International Journal of COPD. - 1178-2005. ; 14, s. 1075-1083
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Tidskriftsartikel (refereegranskat)abstract
- Background and aim: The value of the forced expiratory volume in one second (FEV1) is useful in the diagnosis and prognosis of chronic obstructive pulmonary disease (COPD). Previous studies on lung function in individuals with severe alpha-1 antitrypsin deficiency (AATD) have shown a variable annual decline in FEV1 (∆FEV1). The aim of this study was to analyze ∆FEV1 and to identify risk factors for ∆FEV1 in individuals with severe AATD.Material and methods: Data on smoking habits, symptoms, results of lung function tests and exacerbations were obtained from the Swedish AATD Register and the Swedish National Patient Register (SNPR). The ∆FEV1 was analyzed by random-effects modeling and adjusted for age and FEV1 at baseline.Results: One hundred and four (9%) current smokers, 539 (48%) ex-smokers and 489 (43%) never-smokers were included in the study and followed-up from 1991 to 2016. A total of 584 (52%) individuals with severe AATD had COPD at inclusion. The median (IQR) annual severe exacerbation rate was 0.66 (1.4). The adjusted mean ∆FEV1 was significantly higher in the current smokers compared with the ex-smokers and never-smokers (70 [95% CI 56–83] vs 42 [95% CI 36–48] and 32 [95% CI 25–38) mL·yr−1,], in the middle–aged individuals compared with the young individuals (48 [95% CI 41–55] vs 32 [95% CI 18–45] mL·yr−1,), in the individuals with respiratory symptoms at inclusion compared with the asymptomatic individuals (46 [95% CI 40–52] vs 30 [95% CI 22–38]mL·yr−1,), and in the individuals with frequent exacerbations compared with those with infrequent exacerbations (57 [95% CI 47–68] vs 27 [95% CI 17–37] mL·yr−1,).Conclusion: Active smoking, age, respiratory symptoms at baseline and repeated severe exacerbations of COPD are factors associated with an accelerated decline of lung function in individuals with severe AATD.
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| 66857. |
- Hiller, Adriana Maria, et al.
(författare)
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The Clinical Course of Severe Alpha-1-Antitrypsin Deficiency in Patients Identified by Screening
- 2022
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Ingår i: International journal of chronic obstructive pulmonary disease. - 1178-2005. ; 17, s. 43-52
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Tidskriftsartikel (refereegranskat)abstract
- Background: Severe alpha-1-antitrypsin deficiency (AATD) is a genetic condition predisposing to chronic obstructive pulmonary disease (COPD) and liver disease. Its natural course is not well known. Our aim was to study the natural course of AATD by analyzing the clinical course in individuals with severe AATD identified by screening.Materials and Methods: Of the 1585 individuals included in the Swedish AATD register, 377 (24%) were identified by screening and included in this retrospective study. The follow-up time was from the date of inclusion in the register to the first lung transplantation, death or the termination of the study on June 1st, 2016. The risk factors for having a diagnosis of COPD were investigated through a proportional hazards model, adjusted for sex, diagnosis before the age of 14 years, smoking habits, occupational exposure to airway irritants and respiratory symptoms or diseases.Results: At inclusion, 71% of the individuals were asymptomatic, ie, without any respiratory symptoms. Compared to the 156 (41%) ever-smokers, the 221 (59%) never-smokers had better lung function (mean FEV1 98 (SD 18) vs 85 (SD 28) % predicted; p < 0.001), and fewer of them were symptomatic, ie, with respiratory symptoms, at inclusion (20% vs 42%; p < 0.001). They also had a lower annual decline in FEV1 (mean 42 (95% CI 36-47) vs 53 (95% CI 47-60) mL·yr-1; p = 0.011) and better survival than the ever-smokers. The risk factors for having a diagnosis of COPD were the identification of severe AATD at an age of ≥14 years and the presence of respiratory symptoms or diseases.Conclusion: Never-smoking individuals with severe AATD identified by screening have better lung function, fewer symptoms, and better survival compared with the ever-smokers. Screening for AATD at an early age may improve the prognosis of AATD.
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| 66858. |
- Hiller, Gösta, et al.
(författare)
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Regulation of phospholipase C-gamma 2 via phosphatidylinositol 3-kinase in macrophages.
- 2002
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Ingår i: Cellular Signalling. - 1873-3913. ; 14:2, s. 169-173
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Tidskriftsartikel (refereegranskat)abstract
- Phospholipase C-gamma (PLC-gamma) isoforms are thought to be activated by both tyrosine phosphorylation and phosphatidylinositol 3,4,5 trisphosphate (PtdIns 3,4,5 P(3)), the product of phosphatidylinositol 3-kinase (PtdIns 3-kinase). In this study, we show that stimulation of mouse macrophages with either zymosan beads or bacteria (Prevotella intermedia) induced tyrosine phosphorylation of PLC-gamma 2. Zymosan stimulation also induced translocation to membrane and cytoskeleton fractions, which was inhibited by the PtdIns 3-kinase inhibitors wortmannin and LY 294002. However, the tyrosine phosphorylation of PLC-gamma 2 induced by zymosan was not affected by the inhibitors wortmannin and LY 294002. In contrast to zymosan and bacteria, PLC-gamma 2 was not phosphorylated by stimulation with lipopolysaccharide (LPS), phorbol ester or calcium ionophore. Moreover, the PLC-gamma 1 isoform was not detected in mouse macrophages. These data indicate that PtdIns 3-kinase is critical for the translocation but not for the tyrosine phosphorylation of PLC-gamma 2 in mouse macrophages and that the latter may be insufficient for enzyme activation.
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| 66859. |
- Hillerberg, Arne, et al.
(författare)
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Analysis of crack formation and crack growth in concrete by means of fracture mechanics and finite elements
- 1976
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Ingår i: Cement and Concrete Research. - : Elsevier BV. - 0008-8846. ; 6:6, s. 773-782
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Tidskriftsartikel (refereegranskat)abstract
- A method is presented in which fracture mechanics is introduced into finite element analysis by means of a model where stresses are assumed to act across a crack as long as it is narrowly opened. This assumption may be regarded as a way of expressing the energy adsorption GC in the energy balance approach, but it is also in agreement with results of tension tests. As a demonstration the method has been applied to the bending of an unreinforced beam, which has led to an explanation of the difference between bending strength and tensile strength, and of the variation in bending strength with beam depth.
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| 66860. |
- Hillerich, Karla, et al.
(författare)
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Cu particle seeded InP InAs axial nanowire heterostructures
- 2013
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Ingår i: Physica Status Solidi. Rapid Research Letters. - : Wiley. - 1862-6254. ; 7:10, s. 850-854
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate the epitaxial growth of alternating InP-InAs nanowire heterostructures using Cu seed particles in MOVPE. We observe extraordinary early stages in the formation of InAs segments, e.g. three-dimensional nucleation instead of step-flow growth. Furthermore, InAs segments of thin nanowires exhibit extended 4H crystal structure.
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