| 1. |
- Aasa, Mikael, et al.
(författare)
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Cost and health outcome of primary percutaneous coronary intervention versus thrombolysis in acute ST-segment elevation myocardial infarction-Results of the Swedish Early Decision reperfusion Study (SWEDES) trial.
- 2010
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Ingår i: American heart journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 160:2, s. 322-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In ST-elevation myocardial infarction, primary percutaneous coronary intervention (PCI) has a superior clinical outcome, but it may increase costs in comparison to thrombolysis. The aim of the study was to compare costs, clinical outcome, and quality-adjusted survival between primary PCI and thrombolysis. METHODS: Patients with ST-elevation myocardial infarction were randomized to primary PCI with adjunctive enoxaparin and abciximab (n = 101), or to enoxaparin followed by reteplase (n = 104). Data on the use of health care resources, work loss, and health-related quality of life were collected during a 1-year period. Cost-effectiveness was determined by comparing costs and quality-adjusted survival. The joint distribution of incremental costs and quality-adjusted survival was analyzed using a nonparametric bootstrap approach. RESULTS: Clinical outcome did not differ significantly between the groups. Compared with the group treated with thrombolysis, the cost of interventions was higher in the PCI-treated group ($4,602 vs $3,807; P = .047), as well as the cost of drugs ($1,309 vs $1,202; P = .001), whereas the cost of hospitalization was lower ($7,344 vs $9,278; P = .025). The cost of investigations, outpatient care, and loss of production did not differ significantly between the 2 treatment arms. Total cost and quality-adjusted survival were $25,315 and 0.759 vs $27,819 and 0.728 (both not significant) for the primary PCI and thrombolysis groups, respectively. Based on the 1-year follow-up, bootstrap analysis revealed that in 80%, 88%, and 89% of the replications, the cost per health outcome gained for PCI will be <$0, $50,000, and $100,000 respectively. CONCLUSION: In a 1-year perspective, there was a tendency toward lower costs and better health outcome after primary PCI, resulting in costs for PCI in comparison to thrombolysis that will be below the conventional threshold for cost-effectiveness in 88% of bootstrap replications.
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| 2. |
- Aasa, Mikael, et al.
(författare)
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Risk Reduction for Cardiac Events After Primary Coronary Intervention Compared With Thrombolysis for Acute ST-Elevation Myocardial Infarction (Five-Year Results of the Swedish Early Decision Reperfusion Strategy [SWEDES] Trial).
- 2010
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Ingår i: The American journal of cardiology. - : Elsevier BV. - 1879-1913 .- 0002-9149. ; 106:12, s. 1685-91
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Tidskriftsartikel (refereegranskat)abstract
- Primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction compares favorably to thrombolysis. In previous studies the benefit has been restricted to the early postinfarction period with no additional risk decrease beyond this period. Long-term outcome after use of third-generation thrombolytics and modern adjunctive pharmaceutics in the 2 treatment arms has not been investigated. This study was conducted to compare 5-year outcome after updated regimens of PPCI or thrombolysis. Patients with ST-elevation myocardial infarction were randomized to enoxaparin and abciximab followed by PPCI (n = 101) or enoxaparin followed by reteplase (n = 104), with prehospital initiation of therapy in 42% of patients. Data on survival and major cardiac events were obtained from Swedish national registries after 5.3 years. PPCI resulted in a better outcome with respect to the composite of death or recurrent myocardial infarction (hazard ratio 0.54, confidence interval 0.31 to 0.95) compared to thrombolysis. This was attributed to a significant decrease in cardiac deaths (hazard ratio 0.16, confidence interval 0.04 to 0.74). The difference evolved continuously over the 5-year follow-up. After adjustment for covariates, a significant benefit remained with respect to cardiac death or recurrent infarction but not for the composite of total survival or recurrent myocardial infarction (p = 0.07). The observed differences were not seen in patients in whom therapy was initiated in the prehospital phase. In conclusion, PPCI in combination with enoxaparin and abciximab compares favorably to thrombolysis in combination with enoxaparin with a risk decrease that stretches beyond the early postinfarction period. Prehospital thrombolysis may, however, match PPCI in long-term outcome.
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| 3. |
- Abarenkov, Kessy, et al.
(författare)
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Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard – a report from a May 23-24, 2016 workshop (Gothenburg, Sweden)
- 2016
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Ingår i: MycoKeys. - : Pensoft Publishers. - 1314-4057 .- 1314-4049. ; 16, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Recent molecular studies have identified substantial fungal diversity in indoor environments. Fungi and fungal particles have been linked to a range of potentially unwanted effects in the built environment, including asthma, decay of building materials, and food spoilage. The study of the built mycobiome is hampered by a number of constraints, one of which is the poor state of the metadata annotation of fungal DNA sequences from the built environment in public databases. In order to enable precise interrogation of such data – for example, “retrieve all fungal sequences recovered from bathrooms” – a workshop was organized at the University of Gothenburg (May 23-24, 2016) to annotate public fungal barcode (ITS) sequences according to the MIxS-Built Environment annotation standard (http://gensc.org/mixs/). The 36 participants assembled a total of 45,488 data points from the published literature, including the addition of 8,430 instances of countries of collection from a total of 83 countries, 5,801 instances of building types, and 3,876 instances of surface-air contaminants. The results were implemented in the UNITE database for molecular identification of fungi (http://unite.ut.ee) and were shared with other online resources. Data obtained from human/animal pathogenic fungi will furthermore be verified on culture based metadata for subsequent inclusion in the ISHAM-ITS database (http://its.mycologylab.org).
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| 6. |
- Abdallah, Nancy, et al.
(författare)
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Combinatorial invariance of Kazhdan-Lusztig-Vogan polynomials for fixed point free involutions
- 2018
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Ingår i: Journal of Algebraic Combinatorics. - : SPRINGER. - 0925-9899 .- 1572-9192. ; 47:4, s. 543-560
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Tidskriftsartikel (refereegranskat)abstract
- When acts on the flag variety of , the orbits are in bijection with fixed point free involutions in the symmetric group . In this case, the associated Kazhdan-Lusztig-Vogan polynomials can be indexed by pairs of fixed point free involutions , where denotes the Bruhat order on . We prove that these polynomials are combinatorial invariants in the sense that if is a poset isomorphism of upper intervals in the Bruhat order on fixed point free involutions, then for all v amp;gt;= u.
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| 7. |
- Abdallah, Nancy, et al.
(författare)
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Free resolutions and Lefschetz properties of some Artin Gorenstein rings of codimension four
- 2024
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Ingår i: Journal of symbolic computation. - 0747-7171 .- 1095-855X. ; 121, s. 102257-102257
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Tidskriftsartikel (refereegranskat)abstract
- In (Stanley, 1978), Stanley constructs an example of an Artinian Gorenstein (AG) ring A with non-unimodal H-vector (1,13,12,13,1). Migliore-Zanello show in (Migliore and Zanello, 2017) that for regularity r=4, Stanley's example has the smallest possible codimension c for an AG ring with non-unimodal H-vector.The weak Lefschetz property (WLP) has been much studied for AG rings; it is easy to show that an AG ring with non-unimodal H-vector fails to have WLP. In codimension c=3 it is conjectured that all AG rings have WLP. For c=4, Gondim shows in (Gondim, 2017) that WLP always holds for r≤4 and gives a family where WLP fails for any r≥7, building on Ikeda's example (Ikeda, 1996) of failure for r=5. In this note we study the minimal free resolution of A and relation to Lefschetz properties (both weak and strong) and Jordan type for c=4 and r≤6.
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| 8. |
- Abdallah, Nancy, et al.
(författare)
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Lefschetz properties of some codimension three Artinian Gorenstein algebras
- 2023
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Ingår i: Journal of Algebra. - : Elsevier BV. - 0021-8693 .- 1090-266X. ; 625, s. 28-45
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Tidskriftsartikel (refereegranskat)abstract
- Codimension two Artinian algebras have the strong and weak Lefschetz properties provided the characteristic is zero or greater than the socle degree. It is open to what extent such results might extend to codimension three Artinian Gorenstein algebras. Despite much work, the strong Lefschetz property for codimension three Artinian Gorenstein algebra has remained largely mysterious; our results build on and strengthen some of the previous results. We here show that every standard-graded codimension three Artinian Gorenstein algebra A having maximum value of the Hilbert function at most six has the strong Lefschetz property, provided that the characteristic is zero. When the characteristic is greater than the socle degree of A, we show that A is almost strong Lefschetz, they are strong Lefschetz except in the extremal pair of degrees.
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| 9. |
- Abdallah, Nancy, et al.
(författare)
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Limits of graded Gorenstein algebras of Hilbert function $$(1,3^k,1)$$
- 2024
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Ingår i: European Journal of Mathematics. - 2199-675X .- 2199-6768. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Let R= k [x, y, z], the polynomial ring over a field k. Several of the authors previously classified nets of ternary conics and their specializations over an algebraically closed field, Abdallah et al. (Eur J Math 9(2), Art. No. 22, 2023). We here show that when k is algebraically closed, and considering the Hilbert function sequence T =(1,3(k),1), k >= 2 (i.e. T = (1, 3, 3, ... , 3, 1) where k is the multiplicity of 3), then the family GT parametrizing graded Artinian algebra quotients A = R/I of R having Hilbert function T is irreducible, and G(T) is the closure of the family Gor(T) of Artinian Gorenstein algebras of Hilbert function T. We then classify up to isomorphism the elements of these families Gor(T) and of G(T). Finally, we give examples of codimension 3 Gorenstein sequences, such as (1, 3, 5, 3, 1), for which G(T) has several irreducible components, one being the Zariski closure of Gor(T).
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| 10. |
- Abdallah, Nancy, et al.
(författare)
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Nets in P^2 and Alexander Duality
- 2023
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Ingår i: Discrete & Computational Geometry. - 0179-5376 .- 1432-0444.
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Tidskriftsartikel (refereegranskat)abstract
- A net in P^2 is a configuration of lines A and points X satisfying certain incidence properties. Nets appear in a variety of settings, ranging from quasigroups to combinatorial design to classification of Kac–Moody algebras to cohomology jump loci of hyperplane arrangements. For a matroid M and rank r, we associate a monomial ideal (a monomial variant of the Orlik–Solomon ideal) to the set of flats of M of rank ≤r. In the context of line arrangements in P^2, applying Alexander duality to the resulting ideal yields insight into the combinatorial structure of nets.
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