| 941. |
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| 942. |
- Gustavsson, Elin, et al.
(författare)
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Surrogate antigens as targets for proteome-wide binder selection
- 2011
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Ingår i: New Biotechnology. - : Elsevier BV. - 1871-6784 .- 1876-4347. ; 28:4, s. 302-311
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Tidskriftsartikel (refereegranskat)abstract
- In the last decade, many initiatives have been taken to develop antibodies for proteome-wide studies, as well as characterization and validation of clinically relevant disease biomarkers. Phage display offers many advantages compared to conventional antibody generation by immunization and hybridoma technology, since it is an unlimited resource of affinity reagents without batch-to-batch variation and is amendable for high throughput. One of the major bottlenecks to proteome-wide binder selection is the limited supply of suitable target antigens representative of the human proteome. Here, we provide proof of principle of using easily accessible, cancer-associated protein epitope signature tags (PrESTs), routinely generated within the Human Protein Atlas project, as surrogate antigens in phage selectionsfor the retrieval of target specific binders. These binders were subsequently tested in western blot, immunohistochemistry and protein microarray application to demonstrate their functionality.
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| 943. |
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| 944. |
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| 945. |
- Haghbin, Saeid, 1977, et al.
(författare)
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An Integrated 20-kW Motor Drive and Isolated Battery Charger for Plug-In Vehicles
- 2013
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Ingår i: IEEE transactions on power electronics. - 0885-8993 .- 1941-0107. ; 28:8, s. 4013-4029
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Tidskriftsartikel (refereegranskat)abstract
- For vehicles using grid power to charge the battery, traction circuit components are not normally engaged during the charging time, so there is a possibility to use them in the charger circuit to have an on-board integrated motor drive and battery charger. An isolated high-power three-phase integrated motor drive and charger based on a split-phase permanent magnet motor is presented in this paper. The motor winding connections are reversible by a relay-based switching device for traction and battery charging. In traction mode, the motor is a classical three-phase motor, but in charging mode it is a rotating isolating transformer providing a three-phase voltage source for the inverter to charge the battery. A mathematical model of the motor with six stator windings is presented for an arbitrary phase shift in windings. For the charging mode, the split-phase motor grid synchronization process and charge control are explained including the developed controller. A 20-kW system is designed and implemented to verify the proper operation of the proposed system. Simulation and practical results are provided to show the system performance in terms of functionality, dynamic response, and efficiency. Moreover, some discussions, recommendations, and limitations are provided to give more practical insights.
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| 946. |
- Hallonsten, Olof, et al.
(författare)
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Analyzing structural stratification in the Swedish higher education system : data contextualization with policy-history analysis
- 2013
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Ingår i: Journal of The American Society For Information Science And Technology. - : Wiley. - 1532-2882 .- 1532-2890. ; 64:3, s. 574-586
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Tidskriftsartikel (refereegranskat)abstract
- 20th century massification of higher education and research in academia is said to have produced structurally stratified higher education systems in many countries. Most manifestly, the research mission of universities appears to be divisive. Authors have claimed that the Swedish system, while formally unified, has developed into a binary state, and statistics seem to support this conclusion. This article makes use of a comprehensive statistical data source on Swedish higher education institutions to illustrate stratification, and uses literature on Swedish research policy history to contextualize the statistics. Highlighting the opportunities as well as constraints of the data, the article argues that there is great merit in combining statistics with a qualitative analysis when studying the structural characteristics of national higher education systems. Not least the article shows that it is an over-simplification to describe the Swedish system as binary; the stratification is more complex. On basis of the analysis, the article also argues that while global trends certainly influence national developments, higher education systems have country-specific features that may enrich the understanding of how systems evolve and therefore should be analyzed as part of a broader study of the increasingly globalized academic system.
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| 947. |
- Hallonsten, Olof
(författare)
-
Big Science Transformed : Science, Politics and Organization in Europe and the United States
- 2016
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Bok (refereegranskat)abstract
- This book analyses the emergence of a transformed Big Science in Europe and the United States, using both historical and sociological perspectives. It shows how technology-intensive natural sciences grew to a prominent position in Western societies during the post-World War II era, and how their development cohered with both technological and social developments. At the helm of post-war science are large-scale projects, primarily in physics, which receive substantial funds from the public purse. Big Science Transformed shows how these projects, popularly called 'Big Science', have become symbols of progress. It analyses changes to the political and sociological frameworks surrounding publicly-funding science, and their impact on a number of new accelerator and reactor-based facilities that have come to prominence in materials science and the life sciences. Interdisciplinary in scope, this book will be of great interest to historians, sociologists and philosophers of science.
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| 948. |
- Hallonsten, Olof, et al.
(författare)
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Commissioning the University of Excellence : Swedish research policy and new public research funding programmes
- 2012
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Ingår i: Quality in Higher Education. - : Informa UK Limited. - 1353-8322 .- 1470-1081. ; 18:3, s. 367-381
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Tidskriftsartikel (refereegranskat)abstract
- In many countries, current research policy is dominated by managerialism and excellence, manifesting the aim of making universities into national strategic assets in the globally competitive knowledge economy. This article discusses these policy trends and their mirror in recent developments in public funding for academic research, with special attention to Sweden. A review of the language in three consecutive Swedish governmental research bills from the past 10 years shows a clear policy shift towards the promotion of excellence and strategic priority on the level of higher education institutions. Reforms to the funding system, especially the launch of specific strategic excellence funding programmes, are introduced to put the policy in practice. While the policy shift itself might be discursive, the changes to the funding system clearly show a determination on behalf of the Swedish government to increase strategic profiling and the pursuit of excellence in research on behalf of universities. © 2012 Copyright Taylor and Francis Group, LLC.
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| 949. |
- Hallonsten, Olof, et al.
(författare)
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Formation and expansion of a new organizational field in experimental science
- 2015
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Ingår i: Science and Public Policy. - : Oxford University Press (OUP). - 1471-5430 .- 0302-3427. ; 42:6, s. 841-854
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines the formation and expansion of a new organizational field in experimental science: synchrotron radiation laboratories. These labs were once peripheral servants of some specialisms of solid-state physics, but over the 40 years studied they have grown into a worldwide generic resource for tens of thousands of users in a broad spectrum of disciplines. The paper uses insights primarily from historical institutionalism, but also neo-institutional theory, to analyze the formation and expansion of the organizational field of synchrotron radiation laboratories, and thus contributes to the analysis of the rather dramatic growth of this tool for experimental science from a small-scale lab curiosity to a generic research technology. But the key contribution of the paper is to provide insights into multi-level and multi-dimensional change in science systems by analyzing the emergence and expansion of a new organizational field in experimental science, which has implications not least for science policy.
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| 950. |
- Hallonsten, Olof
(författare)
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Growing Big Science in a Small Country : MAX-lab and the Swedish Research Policy System
- 2011
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Ingår i: Historical Studies in the Natural Sciences. - : University of California Press. - 1939-1811 .- 1939-182X. ; 41:2, s. 179-215
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Tidskriftsartikel (refereegranskat)abstract
- MAX-lab is a Swedish national synchrotron radiation facility, first established as a small-scale university project in the late 1970s and then gradually developed into a national and international user facility. This article presents a historical study of MAXlab that illustrates the decentralized character of the Swedish science policy system and especially its lack of aggregation mechanisms for strategically important initiatives such as the establishment of large research infrastructures. The dominating university sector and the absence of strong central governance structures have made Swedish science policy pluralistic, driven from the bottom up, and decentralized. The genesis and development of MAX-lab, while remarkable when compared to other such facilities internationally, is symptomatically Swedish-it has grown from the bottom up and step by step, and thereby managed to become a respected national and international user facility despite unfavorable conditions. The patchy funding model and the lack of coherent policymaking has led to underfunding and an opaque organizational structure, but MAX-lab and its users have nonetheless been of high quality. This article argues that the determination, patience, adaptivity, and, to some extent, ingenuity of the people involved in MAX-lab have compensated for systemic shortcomings and enabled the laboratory to succeed despite the unfavorable conditions.
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