| 1. |
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Airline Economics in Europe
- 2019
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- In recent years, the European air transport industry has seen a number of important changes, with more on the horizon. This comprehensive work presents a multi-faceted analysis of the air industry in Europe, how it has developed in recent years, and how it is set to develop further into the future. The work brings together leading experts in the field from across the continent to address the burning issues affecting this significant sector of the European transportation arena. It begins with a scene-setting contribution that outlines the detail of the regulatory context within which the European airline sector operates. We then move on to look at some of the strategic responses to this evolving regulatory context. In this respect, the specifics of some relevant business models, the competitive context (particularly with respect to pricing and profitability), changes in the productivity of European airlines relative to the global industry and the issue of joint ventures in the transatlantic market are all dealt with in some detail. The focus then shifts to the analysis of more niche sectors within the European aviation sector, specifically the business aviation and air cargo markets. The volume finishes with more specific works which address key issues in today’s European airline market, namely the adoption of new propulsion technology and the ever-present environmental impacts associated with aircraft noise.
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| 2. |
- Baltar, Federico, et al.
(författare)
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High dissolved extracellular enzymatic activity in the deep Central Atlantic Ocean
- 2010
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Ingår i: Aquatic Microbial Ecology. - : Inter-Research Science Center. - 0948-3055 .- 1616-1564. ; 58:3, s. 287-302
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Tidskriftsartikel (refereegranskat)abstract
- The distribution of prokaryotic abundance (PA), prokaryotic heterotrophic production (PHP), and suspended particulate organic material (POM), as well as total and dissolved (operationally defined as passing through 0.2 mu m pore size filters) potential extracellular enzymatic activities (EEA; alpha- and beta-glucosidase [AGase and BGase], leucine aminopeptidase [LAPase], and alkaline phosphatase [APase]) were determined in the meso- and bathypelagic waters of the (sub)tropical Atlantic along an eastern zonal transatlantic transect and a western N-S transect. Significant differences between both transects were found for POM concentration but not for PA, PHP (except in the subsurface and oxygen minimum layer), and dissolved and total EEA. PHP decreased by 3 orders of magnitude from the lower euphotic zone to bathypelagic waters, while PA and cell-specific PHP decreased only by 1 and 2 orders of magnitude, respectively. The proportion of the dissolved to the total EEA was high in the dark ocean for all the enzymes, ranging from 54 to 100, 56 to 100, 65 to 100 and 57 to 97 % for AGase, BGase, LAPase and APase, respectively. The kinetic parameters (V-max, and K-m) of both the dissolved and total fractions of LAPase and APase were very similar throughout the water column, suggesting a similar origin for both dissolved and particulate EEA. Significant correlations of both dissolved and total EEA were found with prokaryotic metabolism and the POM pool. Based on the previous notion that the fraction of dissolved EEA is higher in particle-attached than in free-living microbes, our results suggest that microbial activity in the dark ocean occurs mainly on colloidal and particulate material. This is in agreement with recent genomic evidence. However, these colloidal and particulate materials are prone to disruption during the sampling process. Hence, more selective sampling techniques are needed to specifically collect these deep-water aggregates that probably represent hotspots of microbial activity in the deep ocean.
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| 3. |
- Buckholtz, B., et al.
(författare)
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Remote equipment security in cloud manufacturing systems
- 2016
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Ingår i: International Journal of Manufacturing Research. - : Inderscience Enterprises Ltd.. - 1750-0591. ; 11:2, s. 126-143
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Tidskriftsartikel (refereegranskat)abstract
- With the growing development of cloud manufacturing (CM) applications in industry, one concern potential users have is security of the data, remote machines and operators. Potential security risks in communication with remotely operated manufacturing equipment have been of recent interest. The purpose of this paper is to provide an overview of security measures being considered to ensure the protection of data being sent to physical machines in a CM system. Topics covered include: internet of things, remote equipment control, security concerns in remote equipment control, existing proposed security measures for remote equipment control, and the future outlook of remote equipment control and security in CM systems.
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| 4. |
- Ferrari, Camilla, et al.
(författare)
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Alzheimer's Disease Progression : Factors Influencing Cognitive Decline
- 2018
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 61:2, s. 785-791
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Tidskriftsartikel (refereegranskat)abstract
- Background:Alzheimer's disease (AD) patients present high variability in the rate of cognitive decline. Despite the wide knowledge on factors influencing dementia risk, little is known on what accounts for AD progression. Previous studies on this topic have mainly analyzed each factor separately without taking into account the interaction between genetic and non-genetic factors.Objective:The aim of the present study is to evaluate the role of demographic, clinical, therapeutic, and genetic factors and their interaction on cognitive decline among newly diagnosed AD patients.Methods:We retrospectively selected 160 AD patients diagnosed at the Neurology Unit of Careggi University Hospital of Florence. We evaluated the occurrence of rapid cognitive changes defined as the worsening of more than four points at the Mini-Mental State Examination after 2-year follow up period.Results:Among the 160 AD patients, 50% presented rapid disease progression. Extrapyramidal signs at disease onset were predictors of worse outcome (OR 2.2), especially among Apolipoprotein E (APOE) epsilon 4 allele carriers, while the presence of family history for dementia decreased the risk of rapid progression by about 50%. Higher educated epsilon 4-carriers showed a slower AD progression. We identified the chronic use of aspirin as potential secondary preventative strategy for the non epsilon 4-carriers.Conclusion:At dementia onset, some clinical and demographic data can be predictors of future progression. The outcomes of the present study support the already hypothesized interaction between genetic and non-genetic factors during disease course and suggest genetic-based approaches.
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| 5. |
- Fonseca, Daniela, et al.
(författare)
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Sustainable OrganoCatalyzed Enantioselective Catalytic Michael Additions in Betaine derived Deep Eutectic Solvents
- 2023
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Ingår i: SynOpen. - : Georg Thieme Verlag. - 2509-9396. ; 7:3, s. 374-
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Tidskriftsartikel (refereegranskat)abstract
- The catalyst cinchonidine-squaramide was immobilized within three different deep eutectic solvents (DES): (Betaine: D-Sorbitol: Water), (Betaine: D-Xylitol: Water) and (Betaine: D-Mannitol: Water) and evaluated in a well-known asymmetric Michael addition. These reactions provided excellent yields (up to 99%) and enantioselectivities (up to 98%) using only 1 mol% of catalyst. It was also possible to achieve 9 cycles in reactions with DES (Betaine: D-Sorbitol: Water), proving the high recyclability of this system. In the reactions realized with only 0.5 mol% of catalyst, it was possible to achieve 5 cycles and the products were obtained with high yields (up to 95%) and excellent enantioselectivities (up to 94%), using DES (Betaine: D-Sorbitol: Water)..
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| 6. |
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| 7. |
- Hogenboom, Katja, 1976-
(författare)
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Hacking the code
- 2014
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Annan publikation (populärvet., debatt m.m.)
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| 8. |
- Huang, Jiayu, et al.
(författare)
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A Reconfigurable Near-Sensor Processor for Anomaly Detection in Limb Prostheses
- 2024
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Ingår i: IEEE Transactions on Biomedical Circuits and Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 1932-4545 .- 1940-9990. ; , s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a reconfigurable near-sensor anomaly detection processor to real-time monitor the potential anomalous behaviors of amputees with limb prostheses. The processor is low-power, low-latency, and suitable for equipment on the prostheses and comprises a reconfigurable Variational Autoencoder (VAE), a scalable Self-Organizing Map (SOM) Array, and a window-size-adjustable Markov Chain, which can implement an integrated miniaturized anomaly detection system. With the reconfigurable VAE, the proposed processor can support up to 64 sensor sampling channels programmable by global configuration, which can meet the anomaly detection requirements in different scenarios. A scalable SOM array allows for the selection of different sizes based on the complexity of the data. Unlike traditional time accumulation-based anomaly detection methods, the Markov Chain is utilized to detect time-series-based anomalous data. The processor is designed and fabricated in a UMC 40-nm LP technology with a core area of 1.49 mm2 and a power consumption of 1.81 mW. It achieves real-time detection performance with 0.933 average F1 Score for the FSP dataset within 24.22 s, and 0.956 average F1 Score for the SFDLA-12 dataset within 30.48 s, respectively. The energy dissipation of detection for each input feature is 43.84 nJ with the FSP dataset, and 55.17 nJ with the SFDLA-12 dataset. Compared with ARM Cortex-M4 and ARM Cortex-M33 microcontrollers, the processor achieves energy and area efficiency improvements ranging from 257×, 193× and 11×, 8×, respectively. IEEE
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| 9. |
- Hugerth, Luisa W, et al.
(författare)
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Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome
- 2020
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Ingår i: mSphere. - : American Society for Microbiology. - 2379-5042. ; 5:6
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Tidskriftsartikel (refereegranskat)abstract
- The vaginal microbiome has been connected to a wide range of health outcomes. This has led to a thriving research environment but also to the use of conflicting methodologies to study its microbial composition. Here, we systematically assessed best practices for the sequencing-based characterization of the human vaginal microbiome. As far as 16S rRNA gene sequencing is concerned, the V1-V3 region performed best in silico, but limitations of current sequencing technologies meant that the V3-V4 region performed equally well. Both approaches presented very good agreement with qPCR quantification of key taxa, provided that an appropriate bioinformatic pipeline was used. Shotgun metagenomic sequencing presents an interesting alternative to 16S rRNA gene amplification and sequencing but requires deeper sequencing and more bioinformatic expertise and infrastructure. We assessed different tools for the removal of host reads and the taxonomic annotation of metagenomic reads, including a new, easy-to-build and -use reference database of vaginal taxa. This curated database performed as well as the best-performing previously published strategies. Despite the many advantages of shotgun sequencing, none of the shotgun approaches assessed here agreed with the qPCR data as well as the 16S rRNA gene sequencing.IMPORTANCE The vaginal microbiome has been connected to various aspects of host health, including susceptibility to sexually transmitted infections as well as gynecological cancers and pregnancy outcomes. This has led to a thriving research environment but also to conflicting available methodologies, including many studies that do not report their molecular biological and bioinformatic methods in sufficient detail to be considered reproducible. This can lead to conflicting messages and delay progress from descriptive to intervention studies. By systematically assessing best practices for the characterization of the human vaginal microbiome, this study will enable past studies to be assessed more critically and assist future studies in the selection of appropriate methods for their specific research questions.
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