| 1. |
|
|
| 2. |
- Clementson, Martin, et al.
(författare)
-
Acute scaphoid fractures : Guidelines for diagnosis and treatment
- 2020
-
Ingår i: EFORT Open Reviews. - : Bioscientifica. - 2396-7544 .- 2058-5241. ; 5:2, s. 96-103
-
Tidskriftsartikel (refereegranskat)abstract
- In cases of suspected scaphoid fracture where the initial radiographs are negative, a supplementary MRI, or alternatively CT, should be carried out within three to five days. Fracture classification, assessment of dislocation as well as evaluation of fracture healing is best done on CT with reconstructions in the coronal and sagittal planes, following the longitudinal axis of the scaphoid. After adequate conservative management, union is achieved at six weeks for approximately 90% of nondisplaced or minimally displaced (≤ 0.5 mm) scaphoid waist fractures. Scaphoid waist fractures with moderate displacement (0.5-1.5 mm) can be treated conservatively, but require prolonged cast immobilization for approximately eight to ten weeks. Internal fixation is recommended for all scaphoid waist fractures with dislocation ≥ 1.5 mm. Distal scaphoid fractures can be treated conservatively. The majority heal uneventfully after four to six weeks of immobilization, depending on fracture type. In general, proximal scaphoid fractures should be treated with internal fixation.
|
|
| 3. |
- Kerry, Miriam, et al.
(författare)
-
Multiple antihypertensive use and risk of mortality in residents of aged care services : a prospective cohort study
- 2020
-
Ingår i: Aging Clinical and Experimental Research. - : Springer Science and Business Media LLC. - 1594-0667 .- 1720-8319. ; 32:8, s. 1541-1549
-
Tidskriftsartikel (refereegranskat)abstract
- Aims The objective of this study is to investigate the association between multiple antihypertensive use and mortality in residents with diagnosed hypertension, and whether dementia and frailty modify this association.Methods This is a two-year prospective cohort study of 239 residents with diagnosed hypertension receiving antihypertensive therapy across six residential aged care services in South Australia. Data were obtained from electronic medical records, medication charts and validated assessments. The primary outcome was all-cause mortality and the secondary outcome was cardiovascular-related hospitalizations. Inverse probability weighted Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. Covariates included age, sex, dementia severity, frailty status, Charlson's comorbidity index and cardiovascular comorbidities.Results The study sample (mean age of 88.1 +/- 6.3 years; 79% female) included 70 (29.3%) residents using one antihypertensive and 169 (70.7%) residents using multiple antihypertensives. The crude incidence rates for death were higher in residents using multiple antihypertensives compared with residents using monotherapy (251 and 173/1000 person-years, respectively). After weighting, residents who used multiple antihypertensives had a greater risk of mortality compared with monotherapy (HR 1.40, 95%CI 1.03-1.92). After stratifying by dementia diagnosis and frailty status, the risk only remained significant in residents with diagnosed dementia (HR 1.91, 95%CI 1.20-3.04) and who were most frail (HR 2.52, 95%CI 1.13-5.64). Rate of cardiovascular-related hospitalizations did not differ among residents using multiple compared to monotherapy (rate ratio 0.73, 95%CI 0.32-1.67).Conclusions Multiple antihypertensive use is associated with an increased risk of mortality in residents with diagnosed hypertension, particularly in residents with dementia and among those who are most frail.
|
|
| 4. |
- Wolf, Eva, et al.
(författare)
-
The self-perceived impact of sexual abuse on daily life and general health - an issue to consider in dental care
- 2024
-
Ingår i: Dental Traumatology. - : John Wiley & Sons. - 1600-4469 .- 1600-9657. ; 40:S2, s. 43-52
-
Tidskriftsartikel (refereegranskat)abstract
- Background/Aim: To analyse, from the perspective of adults with a history of sexual abuse, the impact of the experience on their general health and well-being.Material and Methods: The participants comprised 12 strategically selected informants (10 women), aged 19-56; all sexually abused during child- and/or adulthood. They were interviewed in-depth and encouraged to describe the impact of the sexual abuse on their daily lives. The consequences of sexual abuse on oral health have previously been reported. The interviews were recorded digitally, transcribed verbatim and analysed according to qualitative content analysis with an inductive approach.Results: The overall theme illustrating the latent content was Sexual abuse experience-limiting long-term consequences, always present in body and mind. The first category covering the manifest content was 'A lost foothold', with two subcategories: (i) emotional repercussions and (ii) physical health repercussions. The second category was 'The significance of distance to trauma', with two subcategories (i) keeping a distance and tending to escape and (ii) processing the trauma experience-a struggle towards balance.Conclusions: A history of sexual abuse cannot be understood in isolation: the long-term repercussions pervade daily life. However, after disclosure of the abuse and processing the trauma, it is possible to ameliorate some of the negative effects. In this context, the dental setting emerges as a potentially important venue for disclosure as almost every person, sooner or later, visits the dentist.
|
|
| 5. |
- Strokan, N.B., et al.
(författare)
-
Detection of strongly and weakly ionizing radiation by triode structure based on SIC films
- 2003
-
Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 93:9, s. 5714-5719
-
Tidskriftsartikel (refereegranskat)abstract
- The detection of strongly and weakly ionizing radiation by triode structure based on silicon carbide (SiC) films was discussed. The possibility of alpha particle spectrometry in spite of slow carrier transport via diffusion was demonstrated. Analysis showed that the signal generated by weakly ionizing radiation incident on a film had low amplitude.
|
|
| 6. |
- Wang, Chuan, et al.
(författare)
-
Integrated conceptual design of heating system at a Swedish mining company
- 2009
-
Ingår i: Pres09 - 12th Conference Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction. - : AIDIC Servizi S.r.l.. - 9788895608044 ; , s. 129-134
-
Konferensbidrag (refereegranskat)abstract
- LKAB Malmberget is a Swedish mining site located at Malmberget, Sweden. Seven boiler centers are located on north part of Malmberget. There are no connections in between these boiler centers, meaning that it is a decentralized heating system. The heat generated is to heat up buildings and for mine ventilation mainly during the cold periods. The heat is mainly provided from electric and oil boilers. However, most boilers under use are over 20 years old, and it is time to retrofit the boiler system and infrastructure. The purpose of this work is to design and optimize the heating system by the integrated concept. An optimization model based on the mixed integer linear programming (MlLP) has been developed to minimize the total heat production cost, including operation cost and investment cost. The model can be used to calculate how a given heat demand can be satisfied at the lowest possible cost. Four different technical options have been considered in a new centralized heating system. On the basis of data input and assumptions, modeling results indicate that a lower cost could be achieved when a waste heat recovery boiler is installed at the old pelletization plant to recover sensible heat from flue gas. This will lead to a remarkable electricity saving (around 70% saving) compared to the reference case. It has also been noticed that in the optimized cases, oil boilers should not be operated due to a higher price compared to electricity, and by estimation an annual reduction of 3000 ton CO2 and 4.5 ton NOx could be achieved.
|
|
| 7. |
- Carlbäck, Mats, 1965-
(författare)
-
To Be or Not to Be . . . : Brand Affiliation in the Hotel Industry
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A large proportion of any business’s value comprises intangible assets, and for many businesses a considerable part of these assets' value is attributable to brands with which businesses affiliate. In light of increasing affiliation of hotel properties with hotel chains and the increasing importance of branding in the hospitality industry, senior managers/owners should be aware of the importance of concepts such as brand equity and brand value and, better yet, incorporate them into their strategic decision-making processes. The extent to which hotel management scholars and industry practitioners understand or use the concept of brand value attributable to affiliation (BVAA) is, however, limited.The aim of this research project is to increase our understanding of the costs and benefits connected with operating a hotel independently or as part of an affiliation, using both quantitative and qualitative methods. Such an understanding could be used to spur further research but should also be directly applicable by the practitioners.The results of this research indicate that affiliating with a brand matters to managers/owners in the hotel industry, but also that brand-related concepts are used only to a limited extent. One of the studies comprising this dissertation, which included 51,000 hotels in the U.S. during a full economic cycle, suggests that affiliated hotels produced better financial performance than unaffiliated hotels, especially during the global economic recession of 2007–2009. On the other hand, the results from a study of hotels and organisations in Sweden suggest that brand value–related information attributable to affiliation is not used to any large extent in the industry. In the third study, a method for financially evaluating BVAA is developed, making it possible not only to measure whether affiliating produces a positiveBVAA, but also to demonstrate a practical method for financially assessing a current affiliation and the various affiliation options. Consequently, these findings should contribute new ways of treating the strategic question of affiliation.
|
|
| 8. |
- Stavenow, Lars, et al.
(författare)
-
Effects of polycyclic aromatic hydrocarbons on proliferation, collagen secretion and viability of arterial smooth muscle cells in culture
- 1988
-
Ingår i: Artery. - 0098-6127. ; 15:2, s. 94-108
-
Tidskriftsartikel (refereegranskat)abstract
- Previous reports have suggested a role for polycyclic aromatic hydrocarbons in the pathogenesis of atherosclerosis. Therefore, the effects of benzpyren (BP) and dimethylbenzanthracene (DMBA) on the arterial smooth muscle cell (SMC) in culture were studied. DMBA increased the proliferation of bovine and rabbit SMC but not of human embryonal fibroblasts or human SMC. BP did not significantly influence the cell number of bovine SMC. The secretion of newly synthesized collagen was always decreased when SMC were exposed to BP or DMBA. When BP or DMBA were added to SMC in plasma with high lipid levels compared to low levels, a decrease in total cellular DNA was seen together with a relatively higher collagen secretion. The same effects were noted when SMC had been preincubated with platelet factors compared to serum free medium, i.e. diminished cellular DNA and increased collagen secretion after BP or DMBA exposure. Cell death, measured as release of prelabelled 3H-thymidine from cell layers, was increased after exposure to BP 10 micrograms/ml while DMBA 0.05-0.1 microgram/ml led to a significantly lesser cell death compared to controls in serum free media. It was also shown that SMC exposed to DMBA might release mitogenic factors to conditioned media. It is concluded that, depending on the mode of administration, the polycyclic aromatic hydrocarbons BP and DMBA may induce different effects on arterial SMC in vitro as increased or decreased toxicity and collagen secretion, and increased proliferation and that these effects might be of importance in the pathogenesis of atherosclerosis.
|
|
| 9. |
- Chaudhuri, K. Ray, et al.
(författare)
-
Improved Sleep Correlates with Improved Quality of Life and Motor Symptoms with Foslevodopa/Foscarbidopa
- 2024
-
Ingår i: MOVEMENT DISORDERS CLINICAL PRACTICE. - 2330-1619.
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives: Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167). Methods: Pearson correlations between sleep (Parkinson's Disease Sleep Scale-2 [PDSS-2]) and quality of life (QoL; Parkinson's Disease Questionnaire-39), motor experiences of daily living (m-EDL; Movement Disorder Society-Unified Parkinson's Disease Scale Part II), and "Off"/"On" times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS-2 score. Results: Baseline sleep correlated moderately with QoL (r = 0.44, P < 0.001) and weakly with m-EDL (r = 0.28; P < 0.001). Sleep improvement weakly correlated with improved "Off" time (r = 0.37; P < 0.001) and QoL (r = 0.36; P < 0.001). Regression analyses demonstrated significant positive associations for improved sleep, "Off" time, QoL, and m-EDL. Conclusions: Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and "Off" time.
|
|
| 10. |
- Wang, Cong, et al.
(författare)
-
Inhibition of Wnt/beta-catenin signaling promotes epithelial differentiation of mesenchymal stem cells and repairs bleomycin-induced lung injury
- 2014
-
Ingår i: American Journal of Physiology-Cell Physiology. - : American Physiological Society. - 0363-6143 .- 1522-1563. ; 307:3, s. C234-C244
-
Tidskriftsartikel (refereegranskat)abstract
- Idiopathic pulmonary fibrosis is a progressive lung disorder of unknown etiology. Previous studies have shown that aberrant activation of the Wnt/beta-catenin signaling cascade occurs in lungs of patients with idiopathic pulmonary fibrosis. Given the important roles of the Wnt/beta-catenin signaling pathway in the development of pulmonary fibrosis, we targeted this pathway for the intervention of pulmonary fibrosis with XAV939, a small molecule that specifically inhibits Tankyrase 1/2, eventually leading to the degradation of beta-catenin and suppression of the Wnt/beta-catenin signaling pathway. Our results demonstrated that XAV939 significantly inhibited the activation of Wnt/beta-catenin signaling and attenuated bleomycin-induced lung fibrosis in mice, and thus improved the survival of mice with lung injury. Interestingly, previous investigations have confirmed that endogenous and exogenous mesenchymal stem cells could be recruited to the injured lung, although the exact effects of these cells are debatable. To determine the effect of Wnt/beta-catenin signaling in the epithelial differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs), we established a coculture system that contains BM-MSCs and alveolar type II epithelial cells. The in vitro experiments demonstrated that XAV939 could promote the differentiation of BM-MSCs into an epithelium-like phenotype in the coculture system. We also found that XAV939 could inhibit the proliferation and myofibroblast differentiation of NIH/3T3 fibroblasts. This work supports that inhibition of the Wnt/beta-catenin signaling pathway may be exploited for the treatment of idiopathic pulmonary fibrosis for which effective treatment strategies are still lacking.
|
|
