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- Behboudi, Afrouz, 1967, et al.
(författare)
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Evolutionary aspects of the genomic organization of rat chromosome 10.
- 2002
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Ingår i: Cytogenetic and genome research. - : S. Karger. - 1424-8581 .- 1424-859X. ; 96:1-4, s. 52-9
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Tidskriftsartikel (refereegranskat)abstract
- Using FISH and RH mapping a chromosomal map of rat chromosome 10 (RNO10) was constructed. Our mapping data were complemented by other published data and the final map was compared to maps of mouse and human chromosomes. RNO10 contained segments homologous to mouse chromosomes (MMU) 11, 16 and 17, with evolutionary breakpoints between the three segments situated in the proximal part of RNO10. Near one of these breakpoints (between MMU17 and 11) we found evidence for an inversion ancestral to the mouse that was not ancestral to the condition in the rat. Within each of the chromosome segments identified, the gene order appeared to be largely conserved. This conservation was particularly clear in the long MMU11-homologous segment. RNO10 also contained segments homologous to three human chromosomes (HSA5, 16, 17). However, within each segment of conserved synteny were signs of more extensive rearrangements. At least 13 different evolutionary breakpoints were indicated in the rat-human comparison. In contrast to what was found between rat and mouse, the rat-human evolutionary breaks were distributed along the entire length of RNO10.
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| 3. |
- Hallnäs, Lars, 1950
(författare)
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The dark room fashion show
- 2004
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Ingår i: The Nordic Textile Journal. - : University College of Borås. The Swedish School of Textiles. - 1404-2487.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Nilsson, Sven, et al.
(författare)
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Rat–Mouse and Rat–Human Comparative Maps Based on Gene Homology and High-Resolution Zoo-FISH
- 2001
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Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 74:3, s. 287-98
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Tidskriftsartikel (refereegranskat)abstract
- The laboratory rat, Rattus norvegicus, and the laboratory mouse, Mus musculus, are key animal models in biomedical research. A deeper understanding of the genetic interrelationsships between Homo sapiens and these two rodent species is desirable for extending the usefulness of the animal models. We present comprehensive rat–human and rat–mouse comparative maps, based on 1090 gene homology assignments available for rat genes. Radiation hybrid, FISH, and zoo-FISH mapping data have been integrated to produce comparative maps that are estimated to comprise 83–100% of the conserved regions between rat and mouse and 66–82% of the conserved regions between rat and human. The rat–mouse zoo-FISH analysis, supported by data for individual genes, revealed nine previously undetected conserved regions compared to earlier reports. Since there is almost complete genome coverage in the rat–mouse comparative map, we conclude that it is feasible to make accurate predictions of gene positions in the rat based on gene locations in the mouse.
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| 10. |
- Plos, Mario, 1963, et al.
(författare)
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Finite Element Analysis of the New Svinesund Bridge: Design model conversion and analysis of the arch launching
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- During the construction of the New Svinesund Bridge, a monitoring project is conducted on behalf of the Swedish road administration (Vägverket). The Royal Institute of Technology (KTH) is leading this project and is responsible for instrumentation, analysis and documentation in the project. As a part of the monitoring project, a finite element model was accomplished at Chalmers University of Technology, department of structural Engineering and Mechanics. Parallel to the monitoring project, a project concerning bridge assessment and maintenance based on FE analysis and field measurements was initiated at Chalmers University of Technology (Chalmers) on behalf of the Swedish road administration (Vägverket) and the Swedish railway administration (Banverket). The FE model was further developed within this project. The model is intended to be used both by the Royal Institute and Chalmers in their further work with the bridge.A finite element (FE) model of the New Svinesund Bridge was developed, and a simplified analysis of the construction of the bridge was made. The FE model was based on the structural model made by the bridge contractor, Bilfinger Berger (2004). The FE model was verified through comparisons with results obtained from the contractor, using the design model of the bridge. Eigenfrequencies and eigenmodes for different stages during the arch launching were calculated. These were found to correspond reasonably well to what was calculated by Bilfinger Berger, even though the FE analysis gave a little lower eigenfrequencies. The completed bridge was analysed for distributed external loads on the carriageways. The sectional moments and forces in the arch, obtained in the FE analysis showed a good agreement with the results from Bilfinger Berger. The deformations of the arch showed a reasonably good agreement between the models.
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