| 241. |
- de Fine Licht, Karl, 1979, et al.
(författare)
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Defining “Social Sustainability”: Towards a Sustainable Solution to the Conceptual Confusion
- 2019
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Ingår i: Etikk i Praksis. - : Norwegian University of Science and Technology (NTNU) Library. - 1890-3991 .- 1890-4009. ; 13:2, s. 21-39
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Tidskriftsartikel (refereegranskat)abstract
- The interest in "social sustainability" has recently increased in the field of urban development. We want societies, cities, and neighborhoods to be economically and environmentally sustainable, but we also want urban areas that are safe, diverse, walkable, and relaxing, just to mention a few examples. Strikingly, however, there is no consensus regarding what definition of "social sustainability" should be employed. Additionally, some people are skeptical about the prospect of finding a useful definition at all and claim it is impossible to satisfactorily define the concept for various reasons, such as its complexity. A potential first step towards navigating this conceptual maze is to provide desiderata for a definition of social sustainability. We defend a list of nine desiderata and thereby create a theoretical framework for analyzing and constructing a definition of "social sustainability". We also examine the skeptical arguments and find that it is premature to conclude that the goal of finding a useful definition is hopeless. With the criteria in place, the future debate can proceed by assessing definitions of "social sustainability" in a more structured and transparent manner. This activity is of upmost importance if we want to create just cities.
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| 242. |
- De Guglielmo, Domenico, et al.
(författare)
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Analysis and Experimental Evaluation of IEEE 802.15.4e TSCH CSMA-CA Algorithm
- 2017
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 66:2, s. 1573-1588
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Tidskriftsartikel (refereegranskat)abstract
- Time-slotted channel hopping (TSCH) is one of the medium access control (MAC) behavior modes defined in the IEEE 802.15.4e standard. It combines time-slotted access and channel hopping, thus providing predictable latency, energy efficiency, communication reliability, and high network capacity. TSCH provides both dedicated and shared links. The latter is special slots assigned to more than one transmitter, whose concurrent access is regulated by a carrier-sense multiple access with collision avoidance (CSMA-CA) algorithm. In this paper, we develop an analytical model of the TSCH CSMA-CA algorithm to predict the performance experienced by nodes when using shared links. The model allows for deriving a number of metrics, such as delivery probability, packet latency, and energy consumption of nodes. Moreover, it considers the capture effect (CE) that typically occurs in real wireless networks. We validate the model through simulation experiments and measurements in a real testbed. Our results show that the model is very accurate. Furthermore, we found that the CE plays a fundamental role as it can significantly improve the performance experienced by nodes.
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| 243. |
- De Marchi, Tommaso, et al.
(författare)
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Proteogenomics decodes the evolution of human ipsilateral breast cancer
- 2023
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 6:1
-
Tidskriftsartikel (refereegranskat)abstract
- Ipsilateral breast tumor recurrence (IBTR) is a clinically important event, where an isolated in-breast recurrence is a potentially curable event but associated with an increased risk of distant metastasis and breast cancer death. It remains unclear if IBTRs are associated with molecular changes that can be explored as a resource for precision medicine strategies. Here, we employed proteogenomics to analyze a cohort of 27 primary breast cancers and their matched IBTRs to define proteogenomic determinants of molecular tumor evolution. Our analyses revealed a relationship between hormonal receptors status and proliferation levels resulting in the gain of somatic mutations and copy number. This in turn re-programmed the transcriptome and proteome towards a highly replicating and genomically unstable IBTRs, possibly enhanced by APOBEC3B. In order to investigate the origins of IBTRs, a second analysis that included primaries with no recurrence pinpointed proliferation and immune infiltration as predictive of IBTR. In conclusion, our study shows that breast tumors evolve into different IBTRs depending on hormonal status and proliferation and that immune cell infiltration and Ki-67 are significantly elevated in primary tumors that develop IBTR. These results can serve as a starting point to explore markers to predict IBTR formation and stratify patients for adjuvant therapy.
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| 244. |
- De Nutte, R., et al.
(författare)
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Nucleosynthesis in AGB Stars Traced by Oxygen Isotopic Ratios
- 2015
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Ingår i: Conference on Why Galaxies Care About AGB Stars III: A Closer Look in Space and Time, Vienna, 28- July - 1 Aug. 2014: (Astronomical Society of the Pacific Conference Series). - : ASTRONOMICAL SOC PACIFIC. - 9781583818794 ; 497, s. 289-294, s. 289-294
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Konferensbidrag (refereegranskat)abstract
- Isotopic ratios are by far the best diagnostic tracers of the stellar origin of elements, as they are very sensitive to the precise conditions in the nuclear burning regions. They allow us to give direct constraints on stellar evolution models and on the progenitor mass. However, up to now different isotopic ratios have been well constrained for only a handful of Asymptotic Giant Branch (AGB) stars. We present new data on isotopologue lines of a well-selected sample of AGB stars, covering the three spectral classes of C-, S- and M-type stars. We report on the first efforts made in determining accurate isotopologue fractions, focusing on oxygen isotopes which are a crucial tracer of the poorly constrained extra mixing processes in stellar atmospheres.
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| 245. |
- De Nutte, R., et al.
(författare)
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Nucleosynthesis in AGB stars traced by oxygen isotopic ratios I. Determining the stellar initial mass by means of the O-17/O-18 ratio
- 2017
-
Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 600
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. We seek to investigate the O-17/O-18 ratio for a sample of AGB stars containing M-, S-, and C-type stars. These ratios are evaluated in relation to fundamental stellar evolution parameters: the stellar initial mass and pulsation period.Methods. Circumstellar (CO)-C-13-O-16, (CO)-C-12-O-17, and (CO)-C-12-O-18 line observations were obtained for a sample of nine stars with various single-dish long-wavelength facilities. Line intensity ratios are shown to relate directly to the surface O-17/O-18 abundance ratio.Results. Stellar evolution models predict the O-17/O-18 ratio to be a sensitive function of initial mass and to remain constant throughout the entire TP-AGB phase for stars initially less massive than 5 M-circle dot. This makes the measured ratio a probe of the initial stellar mass.Conclusions. Observed O-17/O-18 ratios are found to be well in the range predicted by stellar evolution models that do not consider convective overshooting. From this, accurate initial mass estimates are calculated for seven sources. For the remaining two sources, there are two mass solutions, although there is a larger probability that the low-mass solution is correct. Finally, we present hints at a possible separation between M/S- and C-type stars when comparing the O-17/O-18 ratio to the stellar pulsation period.
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| 246. |
- Derogar, Maryam, et al.
(författare)
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Preparedness for side effects and bother in symptomatic men after radical prostatectomy in a prospective, non-randomized trial
- 2016
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 55:12, s. 1467-1476
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Many clinicians believe that preparedness before surgery for possible post-surgery side effects reduces the level of bother experienced from urinary incontinence and decreased sexual health after surgery. There are no published studies evaluating this belief. Therefore, we aimed to study the level of preparedness before radical prostatectomy and the level of bother experienced from urinary incontinence and decreased sexual health after surgery. MATERIAL AND METHODS: We prospectively collected data from a non-selected group of men undergoing radical prostatectomy in 14 centers between 2008 and 2011. Before surgery, we asked about preparedness for surgery-induced urinary problems and decreased sexual health. One year after surgery, we asked about bother caused by urinary incontinence and erectile dysfunction. As a measure of the association between preparedness and bothersomeness we modeled odds ratios (ORs) by means of logistic regression. RESULTS: Altogether 1372 men had urinary incontinence one year after surgery as well as had no urinary leakage or a small urinary dribble before surgery. Among these men, low preparedness was associated with bother resulting from urinary incontinence [OR 2.84; 95% confidence interval (CI) 1.59-5.10]. In a separate analysis of 1657 men we found a strong association between preparedness for decreased sexual health and experiencing bother from erectile dysfunction (OR 5.92; 95% CI 3.32-10.55). CONCLUSION: In this large-sized prospective trial, we found that preparedness before surgery for urinary problems or sexual side effects decreases bother from urinary incontinence and erectile dysfunction one year after surgery.
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| 247. |
- Dessirier, Benoît, et al.
(författare)
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Modeling early in situ wetting of a compacted bentonite buffer installed in low permeable crystalline bedrock
- 2016
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Ingår i: Water resources research. - 0043-1397 .- 1944-7973. ; 52:8, s. 6207-6221
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Tidskriftsartikel (refereegranskat)abstract
- The repository concept for geological disposal of spent nuclear fuel in Sweden and Finland is planned to be constructed in sparsely fractured crystalline bedrock and with an engineered bentonite buffer to embed the waste canisters. An important stage in such a deep repository is the postclosure phase following the deposition and the backfilling operations when the initially unsaturated buffer material gets hydrated by the groundwater delivered by the natural bedrock. We use numerical simulations to interpret observations on buffer wetting gathered during an in situ campaign, the Bentonite Rock Interaction Experiment, in which unsaturated bentonite columns were introduced into deposition holes in the floor of a 417 m deep tunnel at the Aspo Hard Rock Laboratory in Sweden. Our objectives are to assess the performance of state-of-the-art flow models in reproducing the buffer wetting process and to investigate to which extent dependable predictions of buffer wetting times and saturation patterns can be made based on information collected prior to buffer insertion. This would be important for preventing insertion into unsuitable bedrock environments. Field data and modeling results indicate the development of a de-saturated zone in the rock and show that in most cases, the presence or absence of fractures and flow heterogeneity are more important factors for correct wetting predictions than the total inflow. For instance, for an equal open-hole inflow value, homogeneous inflow yields much more rapid buffer wetting than cases where fractures are represented explicitly thus creating heterogeneous inflow distributions.
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| 248. |
- Di Marco, Igor, et al.
(författare)
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Electron correlations in MnxGa1-xAs as seen by resonant electron spectroscopy and dynamical mean field theory
- 2013
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 4, s. 6-
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Tidskriftsartikel (refereegranskat)abstract
- After two decades since the discovery of ferromagnetism in manganese-doped gallium arsenide, its origin is still debated, and many doubts are related to the electronic structure. Here we report an experimental and theoretical study of the valence electron spectrum of manganese-doped gallium arsenide. The experimental data are obtained through the differences between off- and on-resonance photo emission data. The theoretical spectrum is calculated by means of a combination of density-functional theory in the local density approximation and dynamical mean field theory, using exact diagonalization as impurity solver. Theory is found to accurately reproduce measured data and illustrates the importance of correlation effects. Our results demonstrate that the manganese states extend over a broad range of energy, including the top of the valence band, and that no impurity band splits-off from the valence band edge, whereas the induced holes seem located primarily around the manganese impurity.
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| 249. |
- Diamanti, Klev, 1987-, et al.
(författare)
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Single nucleus transcriptomics data integration recapitulates the major cell types in human liver
- 2021
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Ingår i: Hepatology Research. - : Wiley. - 1386-6346 .- 1872-034X. ; 51:2, s. 233-238
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Tidskriftsartikel (refereegranskat)abstract
- Hepatology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Hepatology Aim: The aim of this study was to explore the benefits of data integration from different platforms for single nucleus transcriptomics profiling to characterize cell populations in human liver. Methods: We generated single-nucleus RNA sequencing data from Chromium 10X Genomics and Drop-seq for a human liver sample. We utilized state of the art bioinformatics tools to undertake a rigorous quality control and to integrate the data into a common space summarizing the gene expression variation from the respective platforms, while accounting for known and unknown confounding factors. Results: Analysis of single nuclei transcriptomes from both 10X and Drop-seq allowed identification of the major liver cell types, while the integrated set obtained enough statistical power to separate a small population of inactive hepatic stellate cells that was not characterized in either of the platforms. Conclusions: Integration of droplet-based single nucleus transcriptomics data enabled identification of a small cluster of inactive hepatic stellate cells that highlights the potential of our approach. We suggest single-nucleus RNA sequencing integrative approaches could be utilized to design larger and cost-effective studies.
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| 250. |
- Dierckx, Anke, 1986, et al.
(författare)
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Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA
- 2011
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 39:10, s. 4513-4524
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Tidskriftsartikel (refereegranskat)abstract
- To increase the diversity of fluorescent base analogues with improved properties, we here present the straightforward click-chemistry-based synthesis of a novel fluorescent adenine-analogue triazole adenine (A(T)) and its photophysical characterization inside DNA. A(T) shows promising properties compared to the widely used adenine analogue 2-aminopurine. Quantum yields reach > 20% and > 5% in single- and double-stranded DNA, respectively, and show dependence on neighbouring bases. Moreover, A(T) shows only a minor destabilization of DNA duplexes, comparable to 2-aminopurine, and circular dichroism investigations suggest that A(T) only causes minimal structural perturbations to normal B-DNA. Furthermore, we find that A(T) shows favourable base-pairing properties with thymine and more surprisingly also with normal adenine. In conclusion, A(T) shows strong potential as a new fluorescent adenine analogue for monitoring changes within its microenvironment in DNA.
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