| 1. |
- Fedele, Renato, et al.
(författare)
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Soliton solutions of the 3D Gross-Pitaevskii equation by a potential control method
- 2010
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Ingår i: New Frontiers in Advanced Plasma Physics. - : AIP. - 9780735408623 ; , s. 61-74
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present a class of three-dimensional solitary waves solutions of the Gross-Pitaevskii (GP) equation, which governs the dynamics of Bose-Einstein condensates (BECs). By imposing an external controlling potential, a desired time-dependent shape of the localized BEC excitation is obtained. The stability of some obtained localized solutions is checked by solving the time-dependent GP equation numerically with analytic solutions as initial conditions. The analytic solutions can be used to design external potentials to control the localized BECs in experiment.
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| 2. |
- Abbas, Syed Adeel, et al.
(författare)
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Spinel-type Na2MoO4 and Na2WO4 as promising optoelectronic materials : First-principle DFT calculations
- 2020
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Ingår i: Chemical Physics. - : Elsevier. - 0301-0104 .- 1873-4421. ; 538
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Tidskriftsartikel (refereegranskat)abstract
- The mechanical, thermodynamic, electronic, and optical properties of Na2MoO4 (NMO) and Na2WO4 (NWO) spinels are elaborated by density functional theory (DFT) based full potential augmented plane wave method (FP-LAPW + lo). Our optimized lattice constants for the studied spinels are in good agreement with that obtained experimentally. The enthalpy of formation ensures the thermodynamic stability of NMO and NWO in the cubic phase. The Born mechanical stability criteria guarantees their mechanical stability, while Poisson ratio (ν) and Pugh's ratio (B/G) infer their brittle behavior. The Debye temperature (θD) is significant for NMO than NWO. The wide bandgap of 3.5 eV for NMO and 4.4 eV for NWO show the maximum absorption in the ultraviolet region that increases their importance for optoelectronic applications. The optical properties are explained in term of dielectric constant, refractive index, absorption of light, reflection, and optical loss factor.
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| 3. |
- Aglago, Elom K., et al.
(författare)
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Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
- 2021
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 13:9
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Tidskriftsartikel (refereegranskat)abstract
- Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
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| 4. |
- Airiskallio, E., et al.
(författare)
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High temperature oxidation of Fe-Al and Fe-Cr-Al alloys : The role of Cr as a chemically active element
- 2010
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Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X .- 1879-0496. ; 52:10, s. 3394-3404
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Tidskriftsartikel (refereegranskat)abstract
- Good high-temperature corrosion resistance of Fe-Al alloys in oxidizing environments is due to the alpha-Al2O3 film which is formed on the surface provided temperature is above 900 degrees C and the Al-content of the alloy exceeds the critical value. Ab initio calculations combined with experiments on Fe-13Al, Fe-18Al, Fe-23Al and Fe-10Cr-10Al alloys show that the beneficial effect of Cr on the oxidation resistance is significantly related to bulk effects. The comparison of experimental and calculated results indicates a clear correlation between the Fe-Cr chemical potential difference and the formation of the protective oxide scales. (C) 2010 Elsevier Ltd. All rights reserved.
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| 5. |
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| 6. |
- Aleksandrova, Elena V, et al.
(författare)
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Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion
- 2023
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally conserved adenine residue 2503 (A2503) of the 23S rRNA by the methyltransferase Cfr. Despite its clinical significance, a sufficient understanding of the molecular mechanisms underlying Cfr-mediated resistance is currently lacking. In this work, we developed a method to express a functionally-active Cfr-methyltransferase in the thermophilic bacterium Thermus thermophilus and report a set of high-resolution structures of the Cfr-modified 70S ribosome containing aminoacyl- and peptidyl-tRNAs. Our structures reveal that an allosteric rearrangement of nucleotide A2062 upon Cfr-methylation of A2503 is likely responsible for the inability of some PTC inhibitors to bind to the ribosome, providing additional insights into the Cfr resistance mechanism. Lastly, by determining the structures of the Cfr-methylated ribosome in complex with the antibiotics iboxamycin and tylosin, we provide the structural bases behind two distinct mechanisms of evading Cfr-mediated resistance.
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| 7. |
- Aleksandrova, Elena V., et al.
(författare)
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Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it
- 2024
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Ingår i: Nature Chemical Biology. - : Springer Nature. - 1552-4450 .- 1552-4469. ; 20:7, s. 867-876
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Tidskriftsartikel (refereegranskat)abstract
- The bacterial ribosome is an essential drug target as many clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent resistance mechanisms to PTC-acting drugs in Gram-positive bacteria is C8-methylation of the universally conserved A2503 nucleobase by Cfr methylase in 23S ribosomal RNA. Despite its clinical importance, a sufficient understanding of the molecular mechanisms underlying Cfr-mediated resistance is currently lacking. Here, we report a set of high-resolution structures of the Cfr-modified 70S ribosome containing aminoacyl- and peptidyl-transfer RNAs. These structures reveal an allosteric rearrangement of nucleotide A2062 upon Cfr-mediated methylation of A2503 that likely contributes to the reduced potency of some PTC inhibitors. Additionally, we provide the structural bases behind two distinct mechanisms of engaging the Cfr-methylated ribosome by the antibiotics iboxamycin and tylosin.
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| 8. |
- Ali, Abukar, 1988, et al.
(författare)
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IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice.
- 2015
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.
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| 9. |
- Ananthanarayanan, G., et al.
(författare)
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Effective straggler mitigation : Attack of the Clones
- 2019
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Ingår i: Proceedings of the 10th USENIX Symposium on Networked Systems Design and Implementation, NSDI 2013. - : USENIX Association. - 9781931971003 ; , s. 185-198
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Konferensbidrag (refereegranskat)abstract
- Small jobs, that are typically run for interactive data analyses in datacenters, continue to be plagued by disproportionately long-running tasks called stragglers. In the production clusters at Facebook and Microsoft Bing, even after applying state-of-the-art straggler mitigation techniques, these latency sensitive jobs have stragglers that are on average 8 times slower than the median task in that job. Such stragglers increase the average job duration by 47%. This is because current mitigation techniques all involve an element of waiting and speculation. We instead propose full cloning of small jobs, avoiding waiting and speculation altogether. Cloning of small jobs only marginally increases utilization because workloads show that while the majority of jobs are small, they only consume a small fraction of the resources. The main challenge of cloning is, however, that extra clones can cause contention for intermediate data. We use a technique, delay assignment, which efficiently avoids such contention. Evaluation of our system, Dolly, using production workloads shows that the small jobs speedup by 34% to 46% after state-of-the-art mitigation techniques have been applied, using just 5% extra resources for cloning.
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| 10. |
- Andersen, U. L., et al.
(författare)
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Quantum information processing with discrete and continuous variables
- 2011
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Ingår i: Optics InfoBase Conference Papers. - 9781557529282
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Konferensbidrag (refereegranskat)abstract
- By means of a hybrid detector we suggest and implement two protocols. We theoretically propose a feasible loophole-free violation of Bell's inequality and we experimentally realize a Hadamard transform of coherent superposition states.
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