| 1. |
- Carlson, Lars A., et al.
(författare)
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A case of massive hypertriglyceridemia corrected by nicotinic acid or nicotinamide therapy
- 1972
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 16:3, s. 359-368
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Tidskriftsartikel (refereegranskat)abstract
- A case of massive hypertriglyceridemia with fasting plasma triglycerides around 100 mmoles/l is described. Large amounts of chylomicra were present in fasting plasma and the amounts of low-density and high-density lipoproteins were very low. Postheparin plasma lipolytic activity was normal and intravenous heparin rapidly cleared the patient's abnormally prolonged alimentary lipemia with a concomitant rise in plasma free fatty acid levels.Nicotinic acid or nictotinamide given in doses of 3 g or more daily reduced plasma triglyceride levels to about 2–3 mmoles/1 and raised the reduced levels of low and high-density lipoproteins. The mode of onset of this therapeutic effect was slow and the effect persisted for several weeks after withdrawal of either nicotinic acid or nicotinamide.The pathogenesis of the hypertriglyceridemia as well as the mode of action of nicotinic acid and nicotinamide is discussed.
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| 2. |
- Carlson, Lars A., et al.
(författare)
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Effect of chlorophenoxyisobutyric acid (CPIB) on fat-mobilizing lipolysis and cyclic AMP levels in rat epididymal fat
- 1972
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 16:3, s. 349-357
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Tidskriftsartikel (refereegranskat)abstract
- High concentrations of chlorophenoxyisobutyric acid (CPIB) reduced basal glycerol release from rat epididymal fat pads in vitro and antagonized the lipolytic effects of noradrenaline. Furthermore, very high concentrations of CPIB significantly antagonized the effects or noradrenaline or ACTH on cyclic AMP accumulation by isolated rat adipocytes. These data are not incompatible with the hypothesis that a primary mechanism in the hypolipidemic action of CPIB is to lower the levels of cyclic AMP in adipose tissue, resulting in decreased hormone-sensitive lipase activity and/or increased lipoprotein lipase activity.
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| 3. |
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| 4. |
- Ingemarsson, Linda, 1972, et al.
(författare)
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Oxidation behavior of a Mo (Si, Al)(2)-based composite at 300-1000 degrees C
- 2010
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Ingår i: Intermetallics. - : Elsevier BV. - 0966-9795 .- 1879-0216. ; 18:4, s. 633-640
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Tidskriftsartikel (refereegranskat)abstract
- The oxidation behavior of a Mo (Si,Al)(2)-based composite of Mo(Si,Al)(2), Al2O3 and Mo-5(Si,Al)(3) (Kanthal Super ER) in synthetic air was investigated. The samples were oxidized isothermally for up to 72 h at 300-1000 degrees C using a thermobalance. The microstructure was analyzed by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Auger Electron Spectroscopy (AES) depth profiling. Broad ion beam milling (BIB) was used to prepare cross-sections. Oxidation behavior depended strongly on the composition of the substrate which consisted of a Mo(Si,Al)(2) matrix and the minority phases Mo-5(Si,Al)(3) and Al2O3. At 300-500 degrees C the mass gains were small with parabolic kinetics, oxidation resulting in a mixture of oxides that reflects the substrate composition. At 600 and 700 degrees C the oxide scale is thin and protective and depleted in molybdenum, a mass loss occurring due to MoO3 vaporization. At 1000 degrees C a protective alpha-alumina scale forms.
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| 5. |
- Persson, Daniel, 1972, et al.
(författare)
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Vesicle size-dependent translocation of penetratin analogs across lipid membranes
- 2004
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Ingår i: Biochimica et Biophysica Acta - Biomembranes. - : Elsevier BV. - 1879-2642 .- 0005-2736. ; 1665:1-2, s. 142-155
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Tidskriftsartikel (refereegranskat)abstract
- The recent discoveries of serious artifacts associated with the use of cell fixation in studies of the cellular uptake of cell-penetrating peptides (CPPs) have prompted a reevaluation of the current understanding of peptide-mediated cellular delivery. Following a report on the differential cellular uptake of a number of penetratin analogs in unfixed cells, we here investigate their membrane translocation abilities in large and giant unilamellar vesicles (LUVs and GUVs, respectively). Surprisingly, in contrast to the behavior in living cells, all peptides readily entered the giant vesicles ( > 1 μm) as proved by confocal microscopy, while none of them could cross the membranes of LUVs (100 nm). For determination of the location of the peptides in the LUVs, a new concept was introduced, based on sensitive resonance energy transfer (RET) measurements of the enhanced fluorescence of acceptor fluorophores present solely in the inner leaflet. An easily adopted method to prepare such asymmetrically labeled liposomes is described. The membrane insertion depths of the tryptophan moieties of the peptides were determined by use of brominated lipids and found to be very similar for all of the peptides studied. We also demonstrate that infrared spectroscopy on the lipid carbonyl stretch vibration peak is a convenient technique to determine phospholipid concentration. © 2004 Elsevier B.V. All rights reserved.
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| 6. |
- Gripeteg, Lena, 1970, et al.
(författare)
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Concomitant Associations of Healthy Food Intake and Cardiorespiratory Fitness With Coronary Artery Calcium
- 2018
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Ingår i: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 122:4, s. 560-564
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Tidskriftsartikel (refereegranskat)abstract
- Conflicting findings remain regarding associations between lifestyle behaviors and coronary artery calcium (CAC). We investigated concomitant associations of healthy food intake and cardiorespiratory fitness (CRF) with CAC. Data from 706 men and women 50 to 64 years old from the Swedish SCAPIS pilot trial were analyzed. A CAC score was calculated using the Agatston method. A Healthy Food Index (HFI) was established using data from a web-based food frequency questionnaire. CRF was assessed from a bike exercise test. Regression analyses were performed with occurrence of CAC (dichotomous) and level of CAC score in patients with CAC (continuous) as outcomes. 58% had 0 CAC score. HFI was significantly associated with having no CAC (standardized coefficient β = 0.18, p <0.001) but not with level of CAC score (β = −0.09, p = 0.34). CRF showed no significant association with having no CAC (β = −0.08, p = 0.12) or with the level of CAC score (β = −0.04, p = 0.64). However, there was an interaction between HFI and CRF (β = −0.23, p = 0.02); for increasing levels of CRF there was stronger negative association between HFI and level of CAC score, reaching β = −0.48, p = 0.045 for the highest CRF level. In conclusion, these results emphasize the importance of a healthy food intake in combination with higher CRF to counteract CAC development.
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| 7. |
- Larsson, Christel, 1972-, et al.
(författare)
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Lifestyle-related characteristics of adolescent low-meat-consumers and omnivores in Sweden and Norway
- 2002
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Ingår i: Journal of Adolescent Health. - 1054-139X .- 1879-1972. ; 31:2, s. 190-198
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Tidskriftsartikel (refereegranskat)abstract
- Methods: A total of 2041 students (578 from Umeå, Sweden; 504 from Stockholm, Sweden; and 959 from Bergen, Norway), with a mean age of 15.5 years, completed a questionnaire. Information was collected about physical characteristics, and health, family situation, social, exercise, alcohol, and tobacco habits. The response rate was 95% in Umeå, 91% in Stockholm, and 83% in Bergen. Statistical analyses included Chi-square and Mann-Whitney U tests.Results: There was no reported difference between low-meat consumers and omnivores with respect to alcohol use, smoking, weight, or amount of exercise. Female low-meat consumers more frequently used smokeless tobacco, reported having more sick days during the last year, attached less importance to “being healthy,” and had been depressed more often than female omnivores. Male low-meat consumers reported, to a greater extent than male omnivores, having been tired without reason, having often had headaches and having been depressed. Female low-meat consumers had parents with a higher average level of education than did female omnivores and more often spent time with friends after school.Conclusions: Vegetarianism or low-meat consumption is mainly a female phenomenon among adolescents in this study. The study indicates that the lifestyle of young low-meat consumers differs from the lifestyle found in previous studies of vegetarians with respect to the respondents’ exercise habits, their perception of their own health, and their use of alcohol and tobacco. Contrary to findings from other studies, adherence to a low-meat diet may not correlate with other health promotion practices among adolescents in Sweden and Norway.
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| 8. |
- Bensow, Rickard, 1972, et al.
(författare)
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Residual Based VMS Subgrid Modeling for Vortex Flows
- 2009
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Ingår i: Computer Methods in Applied Mechanics and Engineering. - : Elsevier BV. - 0045-7825 .- 1879-2138. ; 199:13-16, s. 802-809
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a residual based subgrid modeling approach for Large Eddy Simulations (LES) based on the variational multiscale method as a cure for the problem of preservation of vortices in numerical flow simulation. This approach combines a splitting of the non-linear term in the Navier–Stokes equations into strain and vorticity with a residual based modeling of the subgrid problems. The benefit is that certain driving phenomena, normally not present in subgrid modeling, e.g. vortex stretching, can be seen in the equations.Here, we focus on two of the subgrid terms arising from the subgrid scale problem. The effect of the two terms are illustrated in an LES of a three dimensional flow around a wing where the main feature is the formation and preservation of a tip vortex, an important phenomenon in many aerodynamic and hydrodynamical applications. We see that the addition of the new subgrid terms correctly counteracts the dissipative effect, arising from numerics and turbulence modeling, on the vortex and thus strongly improves prediction of the tip vortex.
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| 9. |
- Boström, Magnus, 1972-, et al.
(författare)
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Sustainable and responsible supply chain governance : challenges and opportunities
- 2015
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Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 107, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- This paper introduces the Special Volume on sustainable and responsible supply chain governance. As globalized supply chains cross multiple regulatory borders, the firms involved in these chains come under increasing pressure from consumers, NGOs and governments to accept responsibility for social and environmental matters beyond their immediate organizational boundaries. Governance arrangements for global supply chains are therefore increasingly faced with sustainability requirements of production and consumption. Our primary objectives for this introductory paper are to explore the governance challenges that globalized supply chains and networks face in becoming sustainable and responsible, and thence to identify opportunities for promoting sustainable and responsible governance. In doing so, we draw on 16 articles published in this Special Volume of the Journal of Cleaner Production as well as upon the broader sustainable supply chain governance literature. We argue that the border-crossing nature of global supply chains comes with six major challenges (or gaps) in sustainability governance and that firms and others attempt to address these using a range of tools including eco-labels, codes of conduct, auditing procedures, product information systems, procurement guidelines, and eco-branding. However, these tools are not sufficient, by themselves, to bridge the geographical, informational, communication, compliance, power and legitimacy gaps that challenge sustainable global chains. What else is required? The articles in this Special Volume suggest that coalition and institution building on a broader scale is essential through, for example, the development of inclusive multi-stakeholder coalitions; flexibility to adapt global governance arrangements to local social and ecological contexts of production and consumption; supplementing effective monitoring and enforcement mechanisms with education and other programs to build compliance capacity; and integration of reflexive learning to improve governance arrangements over time.
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| 10. |
- Bradshaw, Clare, 1972-, et al.
(författare)
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Effects of bottom trawling and environmental factors on benthic bacteria, meiofauna and macrofauna communities and benthic ecosystem processes
- 2024
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Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 921
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Tidskriftsartikel (refereegranskat)abstract
- Soft sediment marine benthic ecosystems comprise a diverse community of bacteria, meiofauna and macrofauna, which together support a range of ecosystem processes such as biogeochemical cycling. These ecosystems are also fishing grounds for demersal species that are often caught using bottom trawling. This fishing method can have deleterious effects on benthic communities by causing injury or mortality, and through alteration of sediment properties that in turn influence community structure. Although the impacts of bottom trawling on macrofauna are relatively well studied, less is known about the responses of meiofauna and bacteria to such disturbances, or how bottom trawling impacts benthic ecosystem processes. Quantifying trawling impacts against a background of natural environmental variability is also a challenge. To address these questions, we examined effects of bottom trawling and a range of environmental variables (e. g. water chemistry and physical and biochemical surface sediment properties) on a) bacterial, meiofaunal and macrofaunal community structure and b) benthic ecosystem processes (nutrient fluxes, extracellular enzyme activities and carbon turnover and degradation rates). We also investigated the link between the benthic macrofauna community and the same ecosystem processes. While there was a significant effect of bottom trawling intensity on macrofaunal community structure, the same was not seen for bacterial or meiofaunal community composition, which were more affected by environmental factors, such as surface sediment properties. The labile component of the surface sediment carbon pool was higher at highly trawled sites. Carbon degradation rates, extracellular enzyme activities, oxygen fluxes and some nutrient fluxes were significantly affected by trawling, but ecosystem processes were also strongly linked to the abundance of key bioturbators (Macoma balthica, Halicryptus spinulosus, Scoloplos armiger and Pontoporeia femorata). Although benthic ecosystems were affected by a combination of trawling and natural variability, disentangling these showed that the anthropogenic effects were clearest on the larger component of the community, i.e. macrofauna composition, and on ecosystem processes related to sedimentary carbon.
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