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- Gustafsson, Åsa, et al.
(author)
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Mice with established airway inflammation exert differential cellular responses to inhaled hematite nanoparticles than healthy mice
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Other publication (other academic/artistic)abstract
- The aim of this study was to investigate the inflammatory and immunological responses in the airways and the lung-draining lymph nodes, following lung exposure to hematite nanoparticles (NPs). The responses to hematite NPs were evaluated in both non-sensitized healthy mice, and allergen-sensitized mice, in which the latter represent a group of sensitive individuals with allergic airway disease. This allergic airway disease was induced by sensitization and aerosol challenge to a respiratory allergen resulting in an established eosinophilic and lymphocytic airway inflammation at the time of NP exposure. The mice received either hematite NPs or vehicle (PBS) intratracheally and the cellular responses were evaluated on day 1, 2, and 7, following exposure.Intratracheal instillation of hematite NPs induced an increase of neutrophils, eosinophils, and lymphocytes in the airways of non-sensitized mice on day 1 and 2 following exposure. At these time-points the lymphocytes in the lymph nodes were also increased. In contrast, exposure to hematite NPs in sensitized mice induced a rapid and unspecific cellular reduction in the alveolar space on the first day after exposure. A similar decrease of lymphocytes was also observed in the mediastinal lymph nodes draining the airways. The study did not indicate a reduction of inflammatory cells in the lung tissue or a translocation of cells from alveolar space to lung tissue. Although, mucociliary cellular clearance could be a possible explanation, our finding of cellular decrease also in lung draining lymph nodes point at cell death as the most likely cause to this unspecific cellular reduction.The results indicate that cells in the airways and lymph nodes of individuals with established airway inflammation undergo cell death when exposed to iron oxide NPs. A possible reason to the toxic response is extensive generation of reactive oxygen species (ROS) in the pro-oxidative environment of inflamed airways, which is further catalyzed by Fe ions released by the hematite NPs, or by generation of ROS at the surface of the NPs. Such cell toxic response was not detected in healthy non-sensitized individuals. This study clearly demonstrates the different response of sensitized and non-sensitized mice, and highlights the importance of including individuals with respiratory disorders, such as allergic asthma, when evaluating health effects of inhaled nanomaterials.
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| 2. |
- Ahlberg, Mona, 1966-
(author)
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Being cared for in an Intensive Care Unit – family functioning and support
- 2022
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Doctoral thesis (other academic/artistic)abstract
- When COVID-19 came as an uninvited guest into our everyday lives, nursing in intensive care was affected and thus the studies contain data from both before and during the COVID-19 pandemic.Before the pandemic, most intensive care units, which care for patients with critical illness in a technical setting, allowed family members to visit the patient 24 hours a day. The intensive care unit is a stressful and frightening environment for both the patient and their family. They can be affected both mentally and physically, showing symptoms such as difficulty sleeping, stress and depression. The intensive cared patient often does not remember anything from the time they were cared for in the intensive care unit, and the family needs to explain and recount this unconscious time. During the pandemic, this changed, with restrictions and limited opportunities to visit the hospital and patient due to virus outbreaks. Family members received information about the patient's medical condition by phone from a physician. The overall aim of this thesis was to explore and conceptualise the family functioning of families with a family member treated in the intensive care unit. There was also an intention to describe and evaluate how an intervention affects the family and individual family members in families where a family member received intensive care.In these studies, qualitative, quantitative, as well as mixed methods were utilised. Participants were adult intensive cared patients from seven intensive care clinics, and their families. The results examined between families are based on the patient and family characteristics. The results from study I show that families who have experienced COVID-19 and with a family member who was cared for in an intensive care unit, have existential thoughts. Study II shows no major impact on family function between families, but the answers differ within the families who experienced intensive care. In study III, concerning families experiencing intensive care and attending family health conversations, there was an awareness of family function. The conversations brought the family closer together, through improved understanding of each other. In study IV family functioning, hope and sense of coherence were com-pared among the participants in two intervention groups: Family health conversations and support group conversations. Family functioning and hope were higher in the group that participated in the family health conversations and comprehensibility, meaningfulness and vitality were higher among the participants in the support group conversation. By exploring how family function affects the individual family member and the family as a unit during critical illness and intensive care, new ways of working can be strengthened in the care of patients and their families.
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| 3. |
- Andersson, Egil, et al.
(author)
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Single-photon core-valence double ionization of molecular oxygen
- 2008
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In: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 78, s. 023409-
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Journal article (peer-reviewed)abstract
- Single-photon core-valence double ionization of molecular oxygen has been studied using a magnetic bottle time-of-flight electron coincidence spectrometer. The K-1V-1 double ionization electron spectrum of O-2 is reported and is assigned with the aid of ab initio calculations. A direct comparison of the core-valence double ionization electron spectra with the conventional valence band photoelectron spectrum is made. The lowest core-valence double ionization energy is found to be 571.6 eV and is associated with a (3)Pi dicationic state.
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| 4. |
- Andersson, Åsa, et al.
(author)
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En etnologisk odyssé till Budapest
- 2001
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In: FU-Mummel, vt -2001. Etnologiska Institutionen, Göteborgs universitet.
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Journal article (peer-reviewed)
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| 5. |
- Arslan, Alan A, et al.
(author)
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Circulating vitamin d and risk of epithelial ovarian cancer
- 2009
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In: Journal of oncology. - : Hindawi Limited. - 1687-8450 .- 1687-8469. ; 2009, s. 672492-672500
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Journal article (peer-reviewed)abstract
- We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59-2.01). In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.
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| 9. |
- Bolmsvik, Åsa, 1975-
(author)
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Structural-acoustic vibrations in wooden assemblies : Experimental modal analysis and finite element modelling
- 2013
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Doctoral thesis (other academic/artistic)abstract
- This doctoral thesis concerns flanking transmission in light weight, wooden multi-storey buildings within the low frequency, primarily 20-120 Hz. The overall aim is to investigate how the finite element method can contribute in the design phase to evaluate different junctions regarding flanking transmission.Two field measurements of accelerations in light weight wooden buildings have been evaluated. In these, two sources; a stepping machine, and an electrodynamic shaker, were used. The shaker was shown to give more detailed information. However, since a light weight structure in field exhibit energy losses to surrounding building parts, reliable damping estimates were difficult to obtain.In addition, two laboratory measurements were made. These were evaluated using experimental modal analysis, giving the eigenmodes and the damping of the structures. The damping for these particular structures varies significantly with frequency, especially when an elastomer is used in the floor-wall junction. The overall damping is also higher when elastomers are used in the floor-wall junction in comparison to a screwed junction. By analysing the eigenmodes, using the modal assurance criterion, of the same structure with two types of junctions it was concluded that the modes become significantly different. Thereby the overall behavior differs.Several finite element models representing both the field and laboratory test setups have been made. The junctions between the building blocks in the models have been modeled using tie or springs and dashpots. Visual observation and the modal assurance criterion show that there is more rotational stiffness in the test structures than in the models.The findings in this doctoral thesis add understanding to how modern joints in wooden constructions can be represented by FE modelling. They will contribute in developing FE models that can be used to see the acoustic effects prior to building an entire house. However, further research is still needed.
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| 10. |
- Brinne Roos, Johanna, 1976-
(author)
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Electron Recombination with Small Molecular Ions
- 2007
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Licentiate thesis (other academic/artistic)abstract
- In this thesis I have theoretically studied electron recombination processes with small molecular ions. In these kind of processes resonant states are involved. To calculate the potential energy for these states as a function of internuclear distance, structure calculations and scattering calculations have to be performed. So far I have been studying the ion-pair formation with in electron recombination with H3+. The cross section for this process has been calculated using different kind of models, both a time dependent quantum mechanical and a semiclassical. I have also studied the direct process of dissociative recombination of HF+. To calculate the total cross section for this process, we have performed wave packet propagation on thirty resonant states and summed up the individual cross sections for these states. The cross sections for both these processes have a similar appearance to those measured experimentally in the ion storage ring CRYRING in Stockholm.
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