| 1. |
- Malmgren, Linnea, et al.
(författare)
-
The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation.
- 2023
-
Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 293:3, s. 293-308
-
Tidskriftsartikel (refereegranskat)abstract
- Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
|
|
| 2. |
- Ask, Per, et al.
(författare)
-
A SHORT-TIME-DELAY URINARY FLOWMETER
- 1985
-
Ingår i: Neurourology and Urodynamics. - : Wiley. - 0733-2467 .- 1520-6777. ; 4:3, s. 247-256
-
Tidskriftsartikel (refereegranskat)abstract
- A urinary flowmeter has been designed, using a quickly rotating disc and a balance principle. The flowmeter has a fast and accurate response to changing flows. The time delay of the flowmeter is less than about 0.25 s. The improved accuracy in recording urinary flow using the presented flowmeter should make it possible to extract more information from the detrusor pressure and urinary flow relations, relevant for assessing lower urinary tract function.
|
|
| 3. |
|
|
| 4. |
- Hobro, Sture, et al.
(författare)
-
Dialysis as a Novel Adjuvant Treatment for Malignant Cancers
- 2022
-
Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:20
-
Forskningsöversikt (refereegranskat)abstract
- Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—thereby forcing ATP production through the Krebs cycle. By the force of dialysis, the cancer cells will be deprived of their preferred fermentable fuels, disrupting major metabolic pathways important for the ability of the cancer cells to survive. Dialysis has the potential to reduce glucose levels below physiological levels, concurrently increase blood ketone body levels and reduce glutamine levels, which may further reinforce the impact of the KC. Importantly, ketones also induce epigenetic changes imposed by histone deacetylates (HDAC) activity (Class I and Class IIa) known to play an important role in cancer metabolism. Thus, dialysis could be an impactful and safe adjuvant treatment, sensitizing cancer cells to traditional cancer treatments (TCTs), potentially making these significantly more efficient.
|
|
| 5. |
- Johansson, Anders, et al.
(författare)
-
Countable state shifts and uniqueness of g-measures
- 2007
-
Ingår i: American Journal of Mathematics. - : Project Muse. - 0002-9327 .- 1080-6377. ; 129:6, s. 1501-1511
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a new approach to studying g-measures which is based upon local absolute continuity. We extend an earlier result that square summability of variations of g ensures uniqueness of g-measures. The first extension is to the case of countably many symbols. The second extension is to some cases where g >= 0, relaxing the earlier requirement that inf g > 0.
|
|
| 6. |
- Johansson, Anders, 1960-, et al.
(författare)
-
Ergodic Theory of Kusuoka Measures
- 2017
-
Ingår i: Journal of Fractal Geometry. - : European Mathematical Society Publishing House. - 2308-1309 .- 2308-1317. ; 4:2, s. 185-214
-
Tidskriftsartikel (refereegranskat)abstract
- In the analysis on self-similar fractal sets, the Kusuoka measure plays an important role. Here we investigate the Kusuoka measure from an ergodic theoretic viewpoint, seen as an invariant measure on a symbolic space. Our investigation shows that the Kusuoka measure generalizes Bernoulli measures and their properties to higher dimensions of an underlying finite dimensional vector space. Our main result is that the transfer operator on functions has a spectral gap when restricted to a certain Banach space that contains the Hölder continuous functions, as well as the highly discontinuous g" role="presentation">g-function associated to the Kusuoka measure. As a consequence, we obtain exponential decay of correlations. In addition, we provide some explicit rates of convergence for a family of generalized Sierpinski gaskets.
|
|
| 7. |
|
|
| 8. |
- Johansson, Anders, 1960-, et al.
(författare)
-
Multifractal analysis of non-uniformly hyperbolic systems
- 2010
-
Ingår i: Israel Journal of Mathematics. - : Springer. - 0021-2172 .- 1565-8511. ; 177:1, s. 125-144
-
Tidskriftsartikel (refereegranskat)abstract
- We prove a multifractal formalismfor Birkhoff averages of continuous functions in the case of some non-uniformly hyperbolic maps, which includes interval examples such as the Manneville-Pomeau map.
|
|
| 9. |
- Johansson, Anders, 1960-, et al.
(författare)
-
Phase transitions in long-range Ising models and an optimal condition for factors of g-measures
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We weaken the assumption of summable variations in a paper by Verbitskiy \cite{verb} to a weaker condition, Berbee's condition, in order for a 1-block factor (a single site renormalisation) of the full shift space on finitely many symbols to have a $g$-measure with a continuous $g$-function. But we also prove by means of a counterexample, that this condition is (within constants) optimal. The counterexample is based on the second of our main results, where we prove that there is an inverse critical temperature in a one-sided long-range Ising model which is at most 8 times the critical inverse temperature for the (two-sided) Ising model with long-range interactions.
|
|
| 10. |
- Johansson, Anders, 1960-, et al.
(författare)
-
Phase transitions in long-range Ising models and an optimal condition for factors of g-measures
- 2019
-
Ingår i: Ergodic Theory and Dynamical Systems. - : Cambridge University Press. - 0143-3857 .- 1469-4417. ; 39:5, s. 1317-1330
-
Tidskriftsartikel (refereegranskat)abstract
- We weaken the assumption of summable variations in a paper by Verbitskiy [On factors of g-measures. Indag. Math. (N.S.) 22 (2011), 315-329] to a weaker condition, Berbee's condition, in order for a one-block factor (a single-site renormalization) of the full shift space on finitely many symbols to have a g-measure with a continuous g-function. But we also prove by means of a counterexample that this condition is (within constants) optimal. The counterexample is based on the second of our main results, where we prove that there is a critical inverse temperature in a one-sided long-range Ising model which is at most eight times the critical inverse temperature for the (two-sided) Ising model with long-range interactions.
|
|
