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- Moore, P. R., et al.
(författare)
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Virtual engineering : an integrated approach to agile manufacturing machinery design and control
- 2003
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Ingår i: Mechatronics (Oxford). - : BioMed Central Ltd.. - 0957-4158 .- 1873-4006. ; 13:10, s. 1105-1121
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Tidskriftsartikel (refereegranskat)abstract
- A virtual manufacturing approach for designing, programming, testing, verifying and deploying control systems for agile modular manufacturing machinery are proposed in this paper. It introduces the concepts, operations, mechanisms and implementation techniques for integrating simulation environments and distributed control system environments so that the control logic programs that have been programmed and verified in the virtual environment can be seamlessly transferred to the distributed control system environment for controlling the real devices. The approach looks to exploit simulation in a much wider range of applications with great advantages in the design and development of manufacturing machine systems. In particular, it facilitates the verification of the runtime support applications using the simulation model before they are applied to the real system. Mechanisms that allow runtime data to be collected during operation of the real machinery to calibrate the simulation models are also proposed. The system implemented delivers a powerful set of software tools for realising agile modular manufacturing systems.
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- Ng, Amos, et al.
(författare)
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Virtual manufacturing for press line monitoring and diagnostics
- 2008
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Ingår i: International journal of machine tools & manufacture. - : Elsevier. - 0890-6955 .- 1879-2170. ; 48:5, s. 565-575
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Tidskriftsartikel (refereegranskat)abstract
- Virtual manufacturing, or manufacturing simulation, can be divided into three domains: product domain, process domain, and resource domain. This paper focuses on the use of virtual manufacturing for press line monitoring and diagnostics. It contains an introduction to virtual manufacturing, divided into a general part on modelling and simulation, verification, validation and acceptance, and the division into the three domains, as well as a specific part on the use of simulation in these domains for sheet metal products, processes and processing equipment. The main software tools discussed in this paper are discrete event simulation and computer-aided robotics; the designed and implemented machine service support system is an example of advanced use of three-dimensional (3-D) graphical simulation in the resource domain. This system offers remote on-line monitoring and diagnostics functions as well as media player-type functions such as replay that allow a service and maintenance expert to analyse disturbances that occur at remote locations. A key feature of the system is 3-D graphical simulation with I/O synchronisation. This type of system is particularly useful for system integrators and machine builders that install press lines and press cells world-wide and need to guarantee a high level of availability of the installed machinery.
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- Partonen, Timo, et al.
(författare)
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Three circadian clock genes Per2, Arnt1, and Npas2 contribute to winter depression
- 2007
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Ingår i: Annals of Medicine. - New York : Informa Healthcare. - 0785-3890 .- 1365-2060. ; 39:3, s. 229-238
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Tidskriftsartikel (refereegranskat)abstract
- Background. Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression.Methods. In silico analysis of the biological effects of allelic differences suggested the target single-nucleotide polymorphisms (SNPs) to be analyzed in a sample of 189 patients and 189 matched controls. The most relevant SNP in each gene was identified for the interaction analysis and included in the multivariate assessment of the combined effects of all three SNPs on the disease risk.Results. SAD was associated with variations in each of the three genes in gene-wise logistic regression analysis. In combination analysis of variations of Per2, Arntl, and Npas2, we found additive effects and identified a genetic risk profile for the disorder. Carriers of the risk genotype combination had the odds ratio of 4.43 of developing SAD as compared with the remaining genotypes, and of 10.67 as compared with the most protective genotype combination.Conclusion. Variations in the three circadian clock genes Per2, Arntl, and Npas2 are associated with the disease, supporting the hypothesis that the circadian clock mechanisms contribute to winter depression.
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