| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- van Bragt, JJMH, et al.
(författare)
-
Characteristics and treatment regimens across ERS SHARP severe asthma registries
- 2020
-
Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 55:1
-
Tidskriftsartikel (refereegranskat)abstract
- Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m−2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day−1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day−1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Ceron, K., et al.
(författare)
-
Ecological Niche Explains the Sympatric Occurrence of Lined Ground Snakes of the Genus Lygophis (Serpentes, Dipsadidae) in the South American Dry Diagonal
- 2021
-
Ingår i: Herpetologica. - 0018-0831. ; 77:3, s. 239-248
-
Tidskriftsartikel (refereegranskat)abstract
- The geographic distribution of a species is limited by many factors, including its ecological and evolutional) , history. Species distribution modeling has been used to evaluate the effects of climate and other variables on geographic distribution and to measure the degree of niche similarity among co-occurring species. Our goal in this study was to compare the geographic distributions and ecological niches of four closely related species of lined ground snakes, Lygophis dilepis, L. flavifrenatus, L. meridionalis, and L. paucidens. These species are distributed along the South American Dry Diagonal. We found that the four species of Lygophis overlap somewhat along their distributions with a low degree of niche overlap. Lygophis dilepis shows a disjunct distribution with two isolated populations. The break in the distribution of L dilepis in Central Brazil is filled by L. meridionalis, which is found mostly in the highlands of the Central Plateau. Because of the disjunct distribution of L. dilepts, we performed species distribution modeling on both populations separately. The environmental niches of the two populations of L. dilepis were indistinguishable according to the niche equivalence tests, but the distribution of one of these populations did not predict the distribution of the second one, and vice versa. Our study shows that niche partitioning may allow for the coexistence of Lygophis species.
|
|
