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- Lindgren, Arne, et al.
(författare)
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A national curriculum in neurology for medical education
- 2004
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Ingår i: Läkartidningen. - 0023-7205. ; 101:26-27, s. 2261-3
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Tidskriftsartikel (refereegranskat)abstract
- The knowledge within medicine is growing rapidly. It has become more and more difficult to decide what knowledge that has to be taught to medical students during their University Medical Degree (MD) education and what has to be omitted from their study plans. As help for teachers and students, a core curriculum of the education defines what is of importance for all students. However, there is a risk of "curriculum overload" with too much information being put into a short time interval. To avoid this and to define what is really the "core" of a course, a national consensus decision may be useful. As an example of this approach, we here report a new joint Swedish core curriculum in neurology for medical students. Teachers responsible for neurological education at all six universities giving University MD education in Sweden have in January 2003 agreed upon the core curriculum that we present. It is our hope that this method can be useful also for other clinical specialities.
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| 3. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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A multiple motion sensors index for motor state quantification in Parkinson's disease
- 2020
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Ingår i: Computer Methods and Programs in Biomedicine. - : Elsevier BV. - 0169-2607 .- 1872-7565. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To construct a Treatment Response Index from Multiple Sensors (TRIMS) for quantification of motor state in patients with Parkinson's disease (PD) during a single levodopa dose. Another aim was to compare TRIMS to sensor indexes derived from individual motor tasks. Method: Nineteen PD patients performed three motor tests including leg agility, pronation-supination movement of hands, and walking in a clinic while wearing inertial measurement unit sensors on their wrists and ankles. They performed the tests repeatedly before and after taking 150% of their individual oral levodopa-carbidopa equivalent morning dose.Three neurologists blinded to treatment status, viewed patients’ videos and rated their motor symptoms, dyskinesia, overall motor state based on selected items of Unified PD Rating Scale (UPDRS) part III, Dyskinesia scale, and Treatment Response Scale (TRS). To build TRIMS, out of initially 178 extracted features from upper- and lower-limbs data, 39 features were selected by stepwise regression method and were used as input to support vector machines to be mapped to mean reference TRS scores using 10-fold cross-validation method. Test-retest reliability, responsiveness to medication, and correlation to TRS as well as other UPDRS items were evaluated for TRIMS. Results: The correlation of TRIMS with TRS was 0.93. TRIMS had good test-retest reliability (ICC = 0.83). Responsiveness of the TRIMS to medication was good compared to TRS indicating its power in capturing the treatment effects. TRIMS was highly correlated to dyskinesia (R = 0.85), bradykinesia (R = 0.84) and gait (R = 0.79) UPDRS items. Correlation of sensor index from the upper-limb to TRS was 0.89. Conclusion: Using the fusion of upper- and lower-limbs sensor data to construct TRIMS provided accurate PD motor states estimation and responsive to treatment. In addition, quantification of upper-limb sensor data during walking test provided strong results. © 2019
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| 4. |
- Aquilonius, Sten-Magnus
(författare)
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Amyotrofisk lateralscleros
- 2007
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Ingår i: Hjärnan. - : Karolinska Institutet University Press, Stockhoolm. - 9789185565139
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Aquilonius, Sten-Magnus, et al.
(författare)
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Den neurologiska undersökningen
- 2006
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Ingår i: Neurologi. - : Liber AB Stockholm. - 9147053135 ; , s. 568-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Aquilonius, Sten-Magnus, et al.
(författare)
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Development of new levodopa treatment strategies in Parkinson’s disease – from bedside to bench to bedside
- 2017
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Ingår i: Upsala Journal of Medical Sciences. - 0300-9734 .- 2000-1967. ; 122:2, s. 71-77
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Forskningsöversikt (refereegranskat)abstract
- This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process from bedside to bench to bedside'.
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| 7. |
- Aquilonius, Sten-Magnus, et al.
(författare)
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Droger och desperation i skilda världar : missbruk av katinon och metkatinon hotar hälsa och social utveckling.
- 2009
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 106:20, s. 1358-1361
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- De betydande sociala och medicinska riskerna vid missbruk av katinon (tuggning av kat) och metkatinon (intravenös injektion av illegala synteser) har i stort sett inte uppmärksammats i svensk narkotikadebatt. Tullens beslag av kat visar hur det traditionella bruket importeras med immigration från framför allt Östafrika. Syntesrecept på metkatinon, som kan hämtas från Internet, ger produkter som orsakat manganförgiftning med svåra, irreversibla motoriska handikapp hos hundratals unga framför allt i Baltikum, Ryssland, Ukraina och Georgien. Denna »epidemi« fortgår. Kunskap om förekomst, kliniska symtom och spridningsrisker vid dessa missbruksformer är angelägen såväl ur ett nationellt som ett internationellt biståndsperspektiv.
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