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- Maury, O., et al.
(författare)
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From shared socio-economic pathways (SSPs) to oceanic system pathways (OSPs) : Building policy-relevant scenarios for global oceanic ecosystems and fisheries
- 2017
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Ingår i: Global Environmental Change. - : Elsevier BV. - 0959-3780 .- 1872-9495. ; 45, s. 203-216
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Tidskriftsartikel (refereegranskat)abstract
- There is an urgent need for developing policy-relevant future scenarios of biodiversity and ecosystem services. This paper is a milestone toward this aim focusing on open ocean fisheries. We develop five contrasting Oceanic System Pathways (OSPs), based on the existing five archetypal worlds of Shared Socioeconomic Pathways (SSPs) developed for climate change research (e.g., Nakicenovic et al., 2014 and Riahi et al., 2016). First, we specify the boundaries of the oceanic social-ecological system under focus. Second, the two major driving forces of oceanic social-ecological systems are identified in each of three domains, viz., economy, management and governance. For each OSP (OSP1 sustainability first, OSP2 conventional trends, OSP3 dislocation, OSP4 global elite and inequality, OSP5 high tech and market), a storyline is outlined describing the evolution of the driving forces with the corresponding SSP. Finally, we compare the different pathways of oceanic social-ecological systems by projecting them in the two-dimensional spaces defined by the driving forces, in each of the economy, management and governance domains. We expect that the OSPs will serve as a common basis for future model based scenario studies in the context of the Intergovernmental Panel on Climate Change (IPCC) and the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES).
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- Arrizabalaga, O., et al.
(författare)
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High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response
- 2017
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Ingår i: Oncogenesis. - : Springer Science and Business Media LLC. - 2157-9024. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- The elucidation of mechanisms involved in resistance to therapies is essential to improve the survival of patients with malignant gliomas. A major feature possessed by glioma cells that may aid their ability to survive therapy and reconstitute tumors is the capacity for self-renewal. We show here that glioma stem cells (GSCs) express low levels of MKP1, a dual-specificity phosphatase, which acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK, while induction of high levels of MKP1 expression are associated with differentiation of GSC. Notably, we find that high levels of MKP1 correlate with a subset of glioblastoma patients with better prognosis and overall increased survival. Gain of expression studies demonstrated that elevated MKP1 impairs self-renewal and induces differentiation of GSCs while reducing tumorigenesis in vivo. Moreover, we identified that MKP1 is epigenetically regulated and that it mediates the anti-tumor activity of histone deacetylase inhibitors (HDACIs) alone or in combination with temozolomide. In summary, this study identifies MKP1 as a key modulator of the interplay between GSC self-renewal and differentiation and provides evidence that the activation of MKP1, through epigenetic regulation, might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma.
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- Maury, O., et al.
(författare)
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A global science-policy partnership for progress toward sustainability of oceanic ecosystems and fisheries
- 2013
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 5:3-4, s. 314-319
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Forskningsöversikt (refereegranskat)abstract
- Oceanic ecosystems support livelihoods and supply food for hundreds of millions of people. But these ecosystems are deteriorating rapidly and many of the world's oceanic fisheries are in a precarious condition. In addition to well-known and pressing fishery management issues, economic globalization is connecting fisheries beyond the frontiers of the organizations responsible for their management and climate-associated changes are deeply modifying ecosystems, pushing them toward new states and no return situations. The status quo is not a sustainable option, and improved international governance is urgently needed to address this situation. Our proposition consists of an inclusive global science-policy process combining major improvements to the present governance systems, including new incentives for international cooperation and coordination, with an ambitious scientific program to help anticipate threats and opportunities and integrate complex information regarding long-term issues. It would constitute a major step toward sustainability.
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