| 1. |
- Hedelin, Maria, et al.
(författare)
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Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism
- 2007
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Ingår i: International Journal of Cancer. - Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. No Calif Canc Ctr, Fremont, CA USA. Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden. Univ Milan, Dept Stat, Milan, Italy. Karolinska Univ Hosp, Ctr Oncol, CLINTEC, Stockholm, Sweden. Wake Forest Univ, Ctr Human Genet, Sch Med, Winston Salem, NC USA. Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA. : WILEY-LISS. - 0020-7136 .- 1097-0215. ; 120:2, s. 398-405
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Tidskriftsartikel (refereegranskat)abstract
- Dietary intake of marine fatty acids from fish may protect against prostate cancer development. We studied this association and whether it is modified by genetic variation in cyclooxygenase (COX)-2, a key enzyme in fatty acid metabolism and inflammation. We assessed dietary intake of fish among 1,499 incident prostate cancer cases and 1,130 population controls in Sweden. Five single nucleotide polymorphisms (SNPs) were identified and genotyped in available blood samples for 1,378 cases and 782 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multivariate logistic regression. Multiplicative and additive interactions between fish intake and COX-2 SNPs on prostate cancer risk were evaluated. Eating fatty fish (e.g. salmon-type fish) once or more per week, compared to never, was associated with reduced risk of prostate cancer (OR: 0.57, 95% CI: 0.43-0.76). The OR comparing the highest to the lowest quartile of marine fatty acids intake was 0.70 (95% CI: 0.51-0.97). We found a significant interaction (p < 0.001) between salmon-type fish intake and a SNP in the COX-2 gene (rs5275: +6365 T/C), but not with the 4 other SNPs examined. We found strong inverse associations with increasing intake of salmon-type fish among carriers of the variant allele (OR for once per week or more vs. never = 0.28, 95% CI: 0.18-0.45; p(trend) < 0.01), but no association among carriers of the more common allele. Frequent consumption of fatty fish and marine fatty acids appears to reduce the risk of prostate cancer, and this association is modified by genetic variation in the COX-2 gene.
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| 2. |
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| 3. |
- Andersson, Ewa, 1980-
(författare)
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Oberoendets praktik
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Independent PracticeDuring the last hundred years, the music industry has evolved with the record labels playing a central role. However, many argue that this situation is about to change as record sales have decreased during the last ten years. This imminent change in the music industry will not only affect the multinational record labels, but also the independent record labels. As record sales have decreased during the last ten years, the number of members in the Swedish Independent Music Producers Association (SOM) has increased and the association now includes 300 independent record labels which are responsible for around 30 percent of the music being produced in Sweden. However, they can be considered a dominated group within the music industry, since they only have around 10 percent of the total market shares when it comes to selling figures. Considering the changes in record sales, the domination of the major record labels and the somewhat fascinating growth of independent actors during turbulent times, this thesis will study how the Swedish independent actors relate to the practices and ideals relevant in the daily work of running an independent record label. The practices studied in this thesis are the practice of work, the practice of recognition and the practice of content production.The purpose of this thesis is to analyse how independence is constructed among the members of SOM. The thesis is based on material collected in a web survey as well as seven interviews with representatives of indie labels. The web survey was distributed to all members of SOM, and the interviewed informants were selected by snowball sampling, using a locator to find informants. The survey material was analysed with cluster and variance analysis, while the interview material was analysed using content analysis – searching for themes connected to the practices. All material is understood through the theoretical frame of the field theory.The main results of the study are that there are different ways of relating to practices among the Swedish independent actors, and that these ways of relating are closely connected to their position within the field. There are common ways of relating to practices such as always promoting DIY, the importance of music and the need to resist the dominance of the major labels. However, the independent actors are not consistent in how these commonalities work in practice. For example, DIY is not applied if it is not economically necessary, and the need to resist the major labels is only apparent when the independent actor has a weaker position within the field. The more established an independent actor is within the field, the lesser resistant he is against the dominating structures of the music industry. As a result of a weakening resistance against the major labels, the independent actors turn to struggle each other.
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| 4. |
- Augustsson, Katarina, et al.
(författare)
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A population-based dietary inventory of cooked meat and assessment of the daily intake of food mutagens
- 1999
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Ingår i: Food Additives and Contaminants. - : Informa UK Limited. - 0265-203X .- 1464-5122. ; 16:5, s. 215-225
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Tidskriftsartikel (refereegranskat)abstract
- Frequent consumption of meat has been associated with an increased risk of colorectal cancer. Such a risk may be due to naturally occurring compounds in the meat, substances added to the meat, or agents formed during cooking. Concerning the latter alternative, mutagenic heterocyclic amines are multi-site animal carcinogens, but their relevance to human cancer has yet to be determined. In the present study, we made a population-based inventory of cooked meat dishes consumed in the county of Stockholm, ranked dishes according to cooking method and frequency of consumption and, in addition, determined levels of mutagenic activity in six commonly consumed fried meat dishes. Meat was consumed, on average, 493 times per year, giving 1.4 daily servings. Frying was the most common way to cook meat. When ranking meat dishes according to intake frequency, the top eight dishes were as follows. sausage, steak casserole, meatballs, pork chops, pork belly, bacon, ground beef patties, and, finally, mincemeat sauce. The frying sessions were pel;formed under controlled conditions at four different temperatures, and we documented the degree of surface browning and measured mutagenic activity in six frequently eaten dishes (sausage, meatballs, pork chops, pork belly, ground beef patties, and minute beef). We found extracts from all six dishes to be mutagenic, and a mean daily dose of exposure was calculated, giving 862 revertants. This investigation leaves no doubt that a major portion of the total meat consumption is fried before ingestion and that fried meat dishes frequently consumed by an elderly population in Stockholm contain mutagenic substances. Furthermore, the study provides usable information for future epidemiological research in which it is necessary to disentangle the effect of meat per se from the effect of potentially carcinogenic heterocyclic amines.
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| 5. |
- Augustsson, Katarina, et al.
(författare)
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A prospective study of intake of fish and marine fatty acids and prostate cancer
- 2003
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 12:1, s. 64-67
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Tidskriftsartikel (refereegranskat)abstract
- Experimental studies suggest that marine fatty acids have an antitumor effect on prostate tumor cells. The aim of this study was to investigate whether high consumption of fish and marine fatty acids reduces the risk of prostate cancer in humans. We followed 47,882 men participating in the Health Professionals Follow-up Study. Dietary intake was assessed in 1986, 1990, and 1994, using a validated food frequency questionnaire. During 12 years of follow-up, 2,482 cases of prostate cancer were diagnosed, of which 617 were diagnosed as advanced prostate cancer including 278 metastatic prostate cancers. Eating fish more than three times per week was associated with a reduced risk of prostate cancer, and the strongest association was for metastatic cancer (multivariate relative risk, 0.56; 95% confidence interval, 0.37-0.86, compared with infrequent consumption, i.e., less than twice per month). Intake of marine fatty acids from food showed a similar but weaker association. Each additional daily intake of 0.5 g of marine fatty acid from food was associated with a 24% decreased risk of metastatic cancer. We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role.
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| 6. |
- Augustsson, Katarina, et al.
(författare)
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Assessment of the human exposure to heterocyclic amines
- 1997
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 18:10, s. 1931-1935
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Tidskriftsartikel (refereegranskat)abstract
- Heterocyclic amines are possible human carcinogens and fried meat is an important source of exposure in the Western diet, To study the effect of heterocyclic amines in humans, accurate assessment of individual food consumption is essential, Parameters influencing the intake include the amount and type of meat ingested, frequency of consumption, cooking method, cooking temperature and the duration of cooking, The aim of the present study was to develop a practical method for assessing individual intakes of specific heterocyclic amines in a large sample of people, This has been done by combining information on food consumption and laboratory findings of heterocyclic amines in food products, Diet was assessed using a semi-quantitative food frequency questionnaire including photos of fried meat and, in all, 22 dishes were cooked and chemically analyzed. The method was employed in an elderly population in Stockholm to estimate the daily mean intake of the five heterocyclic amines 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo [4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo [4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), The total daily intake ranged from none to 1816 ng, with a mean intake of 160 ng, which is well below estimates reported previously, Highest amounts ingested were of PhIP (mean 72, range 0-865 ng/day) and MeIQx (mean 72, range 0-1388 ng/day), followed by DiMeIQx (mean 16, range 0-171 ng/day), while MeIQ and IQ were ingested only in very small amounts (mean <1 ng/day).
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| 7. |
- Augustsson, Katarina, et al.
(författare)
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Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney : a population-based study
- 1999
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 353:9154, s. 703-707
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Tidskriftsartikel (refereegranskat)abstract
- Background Heterocyclic amines formed in cooked meat and fish are carcinogenic in animal models and form DNA adducts in human beings. We undertook a study to assess whether these substances are related to the risks of cancer in the large bowel and urinary tract. Methods In a population-based case-control study, cases were identified from the Swedish cancer registry. Controls were randomly selected from the population register. Information on intake of various foods and was assessed by questionnaire, with photographs of foods cooked at various temperatures. We measured the content of heterocyclic amines in foods cooked under these conditions. Findings Information was retrieved from 553 controls, 352 cases of colon cancer, 249 cases of rectal cancer, 273 cases of bladder cancer, and 138 cases of kidney cancer. The response rate was 80% for controls and 70% for cases. The estimated daily median intake of heterocyclic amines was 77 ng for controls, and 66 ng, 63 ng, 96 ng, and 84 ng for cases with cancer of the colon, rectum, bladder, and kidney, respectively. The relative risk for the intake of heterocyclic amines (highest vs lowest quintile) was 0.6 (95% CI 0.4-1.0) for colon cancer, 0.7 (0.4-1.1) for rectal cancer, 1.2 (0.7-2.1) for bladder cancer, and 1.0 (0.5-1.9) for kidney cancer. Seven cases, but no controls, had an estimated daily intake of heterocyclic amines above 1900 ng. Interpretation Intake of heterocyclic amines, within the usual dietary range in this study population, is unlikely to increase the incidence of cancer in the colon, rectum, bladder, or kidney. For daily intakes above 1900 ng, our data are consistent with human carcinogenicity, but the precision was extremely low.
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| 8. |
- Augustsson, Katarina
(författare)
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Dietary heterocyclic amines and human cancer risk
- 1998
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Heterocyclic amines formed in meat during cooking are multi-site animal carcinogens and form DNA adducts in human tissues, but their relevance to human carcinogenesis has yet to be determined. The aim of this thesis was to investigate, by epidemiological methods, whether heterocyclic amines are responsible for part of the diet-related cancer burden in humans. Frequently eaten fried meat dishes in an elderly population in Stockholm, Sweden, were identified, and we found meat to be eaten, on the average, 1.4 times per day, and frying to be the most popular cooking method. Altogether, 22 frequently consumed dishes were fried/baked in a standardized manner under controlled conditions at 150, 175, 200, and 225°C, and the content of heterocyclic amines, including IQ, MelQ, MelQx, DiMelQx, and PhlP, was determined. The formation of heterocyclic amines was found to be temperature-related and the highest amounts were detected in minute steak, pork filet, and bacon fried at 225°C. A method to assess the individual intake of heterocyclic amines in an epidemiological context was developed by linking values for heterocyclic amines obtained from chemical analyses to food consumption data collected by means of a semi-quantitative food frequency questionnaire comprising 188 food items. Variables used to assess the intake of heterocyclic amines were intake frequency, type of dish, cooking method, portion size, degree of surface browning of the meat, and intake of gravy. When the number or dishes in the food frequency module was reduced from 39 to 15 dishes, based on the most informative dishes according to the total intake or the between-person variance, only a limited amount of misclassification was introduced. The total daily intake of IQ, MelQ, MelQx, DiMelQx, and PhlP among controls ranged from zero to 1816 ng, with a median of 77 ng. Relative risks of cancer were estimated in a population-based case-control study in Stockholm, and information was retrieved from 553 controls, 352 cases of colon cancer, 249 rectal cancer cases, 273 bladder cancer cases, and 138 cases of kidney cancer. The study disentangles the effect of meat from the effect of heterocyclic amines, and we found that an intake of heterocyclic amines within the usual dietary range in the study base is unlikely to increase the incidence of cancer of the colon, rectum, bladder, or kidney. However, for intakes above 1900 ng/day, our data are consistent with the possibility of human carcinogenicity, but the precision is extremely low.
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| 9. |
- Barrett, J H, et al.
(författare)
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Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer
- 2003
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 24:2, s. 275-282
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Tidskriftsartikel (refereegranskat)abstract
- Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA), which are produced by meat cooked at high temperatures and are found in cigarette smoke. A study of 500 incident colorectal cancer cases and population controls, matched for age, sex and general practitioner, was conducted in the UK to investigate this hypothesis. Usual meat intake and lifetime smoking habits were estimated using a detailed questionnaire administered by interview. Subjects also indicated how well cooked they ate their meat. Subjects were classified as fast or slow NAT2 acetylators on the basis of NAT2 genotype. Complete genotype data were available on 433 matched pairs. The risk of colorectal cancer showed a steady increase with meat intake, rising to an odds ratio of 1.51 [95% confidence interval (1.03, 2.23)] for the highest versus the lowest quartile, after adjustment for total energy intake, and this was even more pronounced for red meat [odds ratio 1.97 (1.30, 2.98)]. However, this effect was not influenced by the preference for well-done meat. Smoking was also associated with an increased risk [odds ratio 1.47 (1.10, 1.98) for ever- versus never-smokers]. In both cases and controls similar to40% of subjects were classified as fast acetylators, and the risks associated with (red) meat intake and smoking did not vary with NAT2 status. This study provides no support for the hypothesis that fast NAT2 acetylators are at increased risk of colorectal cancer, even if exposed to high levels of HA from well-cooked meat or smoking.
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| 10. |
- Chang, E T, et al.
(författare)
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Alcohol drinking and risk of localized versus advanced and sporadic versus familial prostate cancer in Sweden
- 2005
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Ingår i: Cancer Causes and Control. - Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden. : SPRINGER. - 0957-5243 .- 1573-7225. ; 16:3, s. 275-284
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Tidskriftsartikel (refereegranskat)abstract
- Background: It is unknown whether the association of alcohol consumption with prostate cancer risk varies between localized and advanced cases, or between sporadic and familial cases. Methods: We assessed recent alcohol drinking in a population-based case-control study of Swedish men, including 1499 cases and 1130 controls. Drinking status and average volume, frequency, and type of alcohol consumed were evaluated. Unconditional logistic regression was performed to estimate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for associations between alcohol consumption and prostate cancer risk. Results: Prostate cancer cases were more likely than controls to be current or former, rather than never, drinkers. However, there was no association between recent total alcohol, beer, wine, and liquor consumption and risk of overall prostate cancer, nor advanced, sporadic, or familial prostate cancer. The OR for risk of overall disease among men who drank more than 135 g of total alcohol per week versus non-drinkers was 1.2 (95% CI: 0.9, 1.5), p(trend)=0.12. There was a marginal positive association between alcohol intake and risk of localized disease. Conclusions: We detected no association between recent alcohol consumption and risk of advanced, sporadic, or familial prostate cancer, and a borderline positive association with localized disease.
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