| 1. |
- Gretarsdottir, Solveig, et al.
(författare)
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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:8, s. 71-692
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Tidskriftsartikel (refereegranskat)abstract
- We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
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| 2. |
- Helgadottir, Anna, et al.
(författare)
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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:2, s. 217-224
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Tidskriftsartikel (refereegranskat)abstract
- Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
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| 3. |
- Howe, John A., et al.
(författare)
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Fjord systems and archives: a review
- 2010
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Ingår i: Geological Society, London, Special Publications. - 0305-8719. ; 344, s. 5-15
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Forskningsöversikt (refereegranskat)abstract
- Fjords are glacially over-deepened semi-enclosed marine basins, typically with entrance sills separating their deep waters from the adjacent coastal waters which restrict water circulation and thus oxygen renewal. The location of fjords is principally controlled by the occurrence of ice sheets, either modern or ancestral. Fjords are therefore geomorphological features that represent the transition from the terrestrial to the marine environment and, as such, have the potential to preserve evidence of environmental change. Typically, most fjords have been glaciated a number of times and some high-latitude fjords still possess a resident glacier. In most cases, glacial erosion through successive glacial/interglacial cycles has ensured the removal of sediment sequences within the fjord. Hence the stratigraphic record in fjords largely preserves a glacial-deglacial cycle of deposition over the last 18 ka or so. Sheltered water and high sedimentation rates have the potential to make fjords ideal depositional environments for preserving continuous records of climate and environmental change with high temporal resolution. In addition to acting as high-resolution environmental archives, fjords can also be thought of as mini-ocean sedimentary basin laboratories. Fjords remain an understudied and often neglected sedimentary realm. With predictions of warming climates, changing ocean circulation and rising sea levels, this volume is a timely look at these environmentally sensitive coastlines.
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