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- Fountoulakis, K.N., et al.
(författare)
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Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study
- 2021
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Ingår i: CNS Spectrums. - : Cambridge University Press. - 1092-8529 .- 2165-6509. ; 26:3, s. 290-298
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Tidskriftsartikel (refereegranskat)abstract
- Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
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| 2. |
- Rondelet, A., et al.
(författare)
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Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis
- 2020
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Ingår i: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 219:2
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Tidskriftsartikel (refereegranskat)abstract
- Clathrin ensures mitotic spindle stability and efficient chromosome alignment, independently of its vesicle trafficking function. Although clathrin localizes to the mitotic spindle and kinetochore fiber microtubule bundles, the mechanisms by which clathrin stabilizes microtubules are unclear. We show that clathrin adaptor interaction sites on clathrin heavy chain (CHC) are repurposed during mitosis to directly recruit the microtubule-stabilizing protein GTSE1 to the spindle. Structural analyses reveal that these sites interact directly with clathrin-box motifs on GTSE1. Disruption of this interaction releases GTSE1 from spindles, causing defects in chromosome alignment. Surprisingly, this disruption destabilizes astral microtubules, but not kinetochore-microtubule attachments, and chromosome alignment defects are due to a failure of chromosome congression independent of kinetochore-microtubule attachment stability. GTSE1 recruited to the spindle by clathrin stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This work uncovers a novel role of clathrin adaptor-type interactions to stabilize nonkinetochore fiber microtubules to support chromosome congression, defining for the first time a repurposing of this endocytic interaction mechanism during mitosis.
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- Qazi, Yasin, et al.
(författare)
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Non-linear magnetic buoyancy instability and turbulent dynamo
- 2024
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 527:3, s. 7994-8005
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Tidskriftsartikel (refereegranskat)abstract
- Stratified discs with strong horizontal magnetic fields, are susceptible to magnetic buoyancy instability (MBI). Modifying the magnetic field and gas distributions, this can play an important role in galactic evolution. The MBI and the Parker instability, in which MBI is exacerbated by cosmic rays, are often studied using an imposed magnetic field. However, in galaxies and accretion discs, the magnetic field is continuously replenished by a large-scale dynamo action. Using non-ideal MHD equations, we model a section of the galactic disc (we neglect rotation and cosmic rays considered elsewhere), in which the large-scale field is generated by an imposed α-effect of variable intensity to explore the interplay between dynamo instability and MBI. The system evolves through three distinct phases: the linear (kinematic) dynamo stage, the onset of linear MBI when the magnetic field becomes sufficiently strong and the non-linear, statistically steady state. Non-linear effects associated with the MBI introduce oscillations which do not occur when the field is produced by the dynamo alone. The MBI initially accelerates the magnetic field amplification but the growth is quenched by the vertical motions produced by MBI. We construct a 1D model, which replicates all significant features of 3D simulations to confirm that magnetic buoyancy alone can quench the dynamo and is responsible for the magnetic field oscillations. Unlike similar results obtained with an imposed magnetic field, the non-linear interactions do not reduce the gas scale height, so the consequences of the magnetic buoyancy depend on how the magnetic field is maintained.
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