| 1. |
- Sen, P, et al.
(författare)
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Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys
- 2023
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Ingår i: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 62:10, s. 3291-3301
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveCOVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys.MethodsThe first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups.ResultsWe analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs – OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs – OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7–10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8–0.97)].ConclusionVaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.
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| 3. |
- Saikia, S. Boro, et al.
(författare)
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Time evolution of magnetic activity cycles in young suns : The curious case of kappa Ceti
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658
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Tidskriftsartikel (refereegranskat)abstract
- Context. A detailed investigation of the magnetic properties of young Sun-like stars can provide valuable information on our Sun's magnetic past and its impact on the early Earth.Aims. We determine the properties of the moderately rotating young Sun-like star kappa Ceti's magnetic and activity cycles using 50 yr of chromospheric activity data and six epochs of spectropolarimetric observations.Methods. The chromospheric activity was determined by measuring the flux in the Call H and K lines. A generalised Lomb-Scargle periodogram and a wavelet decomposition were used on the chromospheric activity data to establish the associated periodicities. The vector magnetic field of the star was reconstructed using the technique of Zeeman Doppler imaging on the spectropolarimetric observations.Results. Our period analysis algorithms detect a 3.1 yr chromospheric cycle in addition to the star's well-known similar to 6 yr cycle period. Although the two cycle periods have an approximate 1:2 ratio, they exhibit an unusual temporal evolution. Additionally, the spectropolarimetric data analysis shows polarity reversals of the star's large-scale magnetic field, suggesting a similar to 10 yr magnetic or Hale cycle.Conclusions. The unusual evolution of the star's chromospheric cycles and their lack of a direct correlation with the magnetic cycle establishes kappa Ceti as a curious young Sun. Such complex evolution of magnetic activity could be synonymous with moderately active young Suns, which is an evolutionary path that our own Sun could have taken.
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| 4. |
- See, V., et al.
(författare)
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The energy budget of stellar magnetic fields
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 453:4, s. 4301-4310
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Tidskriftsartikel (refereegranskat)abstract
- Spectropolarimetric observations have been used to map stellar magnetic fields, many of which display strong bands of azimuthal fields that are toroidal. A number of explanations have been proposed to explain how such fields might be generated though none are definitive. In this paper, we examine the toroidal fields of a sample of 55 stars with magnetic maps, with masses in the range 0.1-1.5M(circle dot). We find that the energy contained in toroidal fields has a power-law dependence on the energy contained in poloidal fields. However the power index is not constant across our sample, with stars less and more massive than 0.5M(circle dot) having power indices of 0.72 +/- 0.08 and 1.25 +/- 0.06, respectively. There is some evidence that these two power laws correspond to stars in the saturated and unsaturated regimes of the rotation-activity relation. Additionally, our sample shows that strong toroidal fields must be generated axisymmetrically. The latitudes at which these bands appear depend on the stellar rotation period with fast rotators displaying higher latitude bands than slow rotators. The results in this paper present new constraints for future dynamo studies.
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