| 1. |
- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 2. |
- Muus, Christoph, et al.
(författare)
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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
- 2021
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:3, s. 546-559
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Tidskriftsartikel (refereegranskat)abstract
- Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the body. We assessed the cell-type-specific expression of ACE2, TMPRSS2 and CTSL across 107 single-cell RNA-sequencing studies from different tissues. ACE2, TMPRSS2 and CTSL are coexpressed in specific subsets of respiratory epithelial cells in the nasal passages, airways and alveoli, and in cells from other organs associated with coronavirus disease 2019 (COVID-19) transmission or pathology. We performed a meta-analysis of 31 lung single-cell RNA-sequencing studies with 1,320,896 cells from 377 nasal, airway and lung parenchyma samples from 228 individuals. This revealed cell-type-specific associations of age, sex and smoking with expression levels of ACE2, TMPRSS2 and CTSL. Expression of entry factors increased with age and in males, including in airway secretory cells and alveolar type 2 cells. Expression programs shared by ACE2(+)TMPRSS2(+) cells in nasal, lung and gut tissues included genes that may mediate viral entry, key immune functions and epithelial-macrophage cross-talk, such as genes involved in the interleukin-6, interleukin-1, tumor necrosis factor and complement pathways. Cell-type-specific expression patterns may contribute to the pathogenesis of COVID-19, and our work highlights putative molecular pathways for therapeutic intervention. An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.
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| 3. |
- Boda, Chad S, et al.
(författare)
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Loss and damage from climate change and implicit assumptions of sustainable development
- 2021
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Ingår i: Climatic Change. - : Springer Nature. - 0165-0009 .- 1573-1480. ; 164, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- Loss and damage from climate change, recognized as a unique research and policy domain through the Warsaw International Mechanism (WIM) in 2013, has drawn increasing attention among climate scientists and policy makers. Labelled by some as the “third pillar” of the international climate regime—along with mitigation and adaptation—it has been suggested that loss and damage has the potential to catalyze important synergies with other international agendas, particularly sustainable development. However, the specific approaches to sustainable development that inform loss and damage research and how these approaches influence research outcomes and policy recommendations remain largely unexplored. We offer a systematic analysis of the assumptions of sustainable development that underpins loss and damage scholarship through a comprehensive review of peer-reviewed research on loss and damage. We demonstrate that the use of specific metrics, decision criteria, and policy prescriptions by loss and damage researchers and practitioners implies an unwitting adherence to different underlying theories of sustainable development, which in turn impact how loss and damage is conceptualized and applied. In addition to research and policy implications, our review suggests that assumptions about the aims of sustainable development determine how loss and damage is conceptualized, measured, and governed, and the human development approach currently represents the most advanced perspective on sustainable development and thus loss and damage. This review supports sustainable development as a coherent, comprehensive, and integrative framework for guiding further conceptual and empirical development of loss and damage scholarship.
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| 4. |
- Chaffin, Brian C., et al.
(författare)
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Biological invasions, ecological resilience and adaptive governance
- 2016
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Ingår i: Journal of Environmental Management. - : Elsevier BV. - 0301-4797 .- 1095-8630. ; 183, s. 399-407
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Tidskriftsartikel (refereegranskat)abstract
- In a world of increasing interconnections in global trade as well as rapid change in climate and land cover, the accelerating introduction and spread of invasive species is a critical concern due to associated negative social and ecological impacts, both real and perceived. Much of the societal response to invasive species to date has been associated with negative economic consequences of invasions. This response has shaped a war-like approach to addressing invasions, one with an agenda of eradications and intense ecological restoration efforts towards prior or more desirable ecological regimes. This trajectory often ignores the concept of ecological resilience and associated approaches of resilience-based governance. We argue that the relationship between ecological resilience and invasive species has been understudied to the detriment of attempts to govern invasions, and that most management actions fail, primarily because they do not incorporate adaptive, learning-based approaches. Invasive species can decrease resilience by reducing the biodiversity that underpins ecological functions and processes, making ecosystems more prone to regime shifts. However, invasions do not always result in a shift to an alternative regime; invasions can also increase resilience by introducing novelty, replacing lost ecological functions or adding redundancy that strengthens already existing structures and processes in an ecosystem. This paper examines the potential impacts of species invasions on the resilience of ecosystems and suggests that resilience-based approaches can inform policy by linking the governance of biological invasions to the negotiation of tradeoffs between ecosystem services.
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| 5. |
- Chaffin, Brian C., et al.
(författare)
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Social-ecological resilience and geomorphic systems
- 2018
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Ingår i: Geomorphology. - : Elsevier BV. - 0169-555X. ; 305, s. 221-230
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Forskningsöversikt (refereegranskat)abstract
- Governance of coupled social-ecological systems (SESs) and the underlying geomorphic processes that structure and alter Earth's surface is a key challenge for global sustainability amid the increasing uncertainty and change that defines the Anthropocene. Social-ecological resilience as a concept of scientific inquiry has contributed to new understandings of the dynamics of change in SESs, increasing our ability to contextualize and implement governance in these systems. Often, however, the importance of geomorphic change and geomorphological knowledge is somewhat missing from processes employed to inform SES governance. In this contribution, we argue that geomorphology and social-ecological resilience research should be integrated to improve governance toward sustainability. We first provide definitions of engineering, ecological, community, and social-ecological resilience and then explore the use of these concepts within and alongside geomorphology in the literature. While ecological studies often consider geomorphology as an important factor influencing the resilience of ecosystems and geomorphological studies often consider the engineering resilience of geomorphic systems of interest, very few studies define and employ a social-ecological resilience framing and explicitly link the concept to geomorphic systems. We present five key concepts—scale, feedbacks, state or regime, thresholds and regime shifts, and humans as part of the system—which we believe can help explicitly link important aspects of social-ecological resilience inquiry and geomorphological inquiry in order to strengthen the impact of both lines of research. Finally, we discuss how these five concepts might be used to integrate social-ecological resilience and geomorphology to better understand change in, and inform governance of, SESs.
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| 6. |
- Cosens, Barbara, et al.
(författare)
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Governing complexity : Integrating science, governance, and law to manage accelerating in the commons
- 2021
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 118:36
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Tidskriftsartikel (refereegranskat)abstract
- The speed and uncertainty of environmental change in the Anthropocene challenge the capacity of coevolving social-ecological-technological systems (SETs) to adapt or transform to these changes. Formal government and legal structures further constrain the adaptive capacity of our SETs. However, new, selforganized forms of adaptive governance are emerging at multiple scales in natural resource-based SETs. Adaptive governance involves the private and public sectors as well as formal and informal institutions, self-organized to fill governance gaps in the traditional roles of states. While new governance forms are emerging, they are not yet doing so rapidly enough to match the pace of environmental change. Furthermore, they do not yet possess the legitimacy or capacity needed to address disparities between the winners and losers from change. These emergent forms of adaptive governance appear to be particularly effective in managing complexity. We explore governance and SETs as coevolving complex systems, focusing on legal systems to understand the potential pathways and obstacles to equitable adaptation. We explore how governments may facilitate the emergence of adaptive governance and promote legitimacy in both the process of governance despite the involvement of nonstate actors, and its adherence to democratic values of equity and justice. To manage the contextual nature of the results of change in complex systems, we propose the establishment of long-term study initiatives for the coproduction of knowledge, to accelerate learning and synergize interactions between science and governance and to foster public science and epistemic communities dedicated to navigating transitions to more just, sustainable, and resilient futures.
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| 7. |
- Garmestani, Ahjond, et al.
(författare)
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Untapped capacity for resilience in environmental law
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:40, s. 19899-19904
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Tidskriftsartikel (refereegranskat)abstract
- Over the past several decades, environmental governance has made substantial progress in addressing environmental change, but emerging environmental problems require new innovations in law, policy, and governance. While expansive legal reform is unlikely to occur soon, there is untapped potential in existing laws to address environmental change, both by leveraging adaptive and transformative capacities within the law itself to enhance social-ecological resilience and by using those laws to allow social-ecological systems to adapt and transform. Legal and policy research to date has largely overlooked this potential, even though it offers a more expedient approach to addressing environmental change than waiting for full-scale environmental law reform. We highlight examples from the United States and the European Union of untapped capacity in existing laws for fostering resilience in social-ecological systems. We show that governments and other governance agents can make substantial advances in addressing environmental change in the short term-without major legal reform-by exploiting those untapped capacities, and we offer principles and strategies to guide such initiatives.
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| 8. |
- Jackson, Guy, et al.
(författare)
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An emerging governmentality of climate change loss and damage
- 2023
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Ingår i: Progress in Environmental Geography. - : SAGE Publications. - 2753-9687. ; 2:1-2, s. 33-57
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Tidskriftsartikel (refereegranskat)abstract
- Loss and damage is the “third pillar” of international climate governance alongside mitigation and adaptation. When mitigation and adaptation fail, losses and damages occur. Scholars have been reacting to international political discourse centred around governing actual or potential severe losses and damages from climate change. Large gaps exist in relation to understanding the underlying power dimensions, rationalities, knowledges, and technologies of loss and damage governance and science. We draw from a Foucauldian-inspired governmentality framework to argue there is an emerging governmentality of loss and damage. We find, among other things, that root causes of loss and damage are being obscured, Western knowledge and technocratic interventions are centred, and there are colonial presupposed subjectivities of Global South victims of climate change, which are being contested by people bearing the brunt of the climate crisis. We propose future directions for critical research on climate change loss and damage.
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| 9. |
- Scown, Murray W., et al.
(författare)
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A harmonized country-level dataset to support the global stocktake regarding loss and damage from climate change
- 2022
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Ingår i: Geoscience Data Journal. - : Wiley. - 2049-6060. ; 9:2, s. 328-340
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Tidskriftsartikel (refereegranskat)abstract
- Under the Paris Agreement, parties should undertake a global stocktake of progress toward meeting the goals of the agreement and tackling climate change. The first global stocktake will be undertaken in 2023, and an assessment of loss and damage from climate change is an important part of the process. Loss and damage refer to the impacts of climate change felt when mitigation and adaptation efforts are inadequate or absent. Much data, including metrics and indicators relevant for loss and damage, are held in existing global databases, but these are disparate and cannot easily be combined and compared to support the global stocktake. We combine relevant primary data sources to provide a harmonized country-level global dataset containing relevant indicators of recorded losses and damages from climate-related events; exposure to climate-related events; country vulnerability and adaptation readiness; scientific studies of climate change attribution; financial support for climate adaptation; and contextual governance conditions. The indicators are standardized against country population and GDP where relevant. We describe original data sources, processing steps, and an overview of key indicators in the dataset. We also compare the assembled data to existing global risk databases; namely, the INFORM risk index and the World Risk Index. This comparison, provided in the Supporting Information, shows a large amount of redundancy among vulnerability and governance indicators, and we suggest that creators of new databases and risk indices be clear about data limitations and the gaps that specific indices attempt to fill in the global data landscape. We recommend the standard use of ISO codes in future databases of this nature, as well as clear metadata regarding how overseas territories are treated relative to their sovereign state, and information on dissolution and creation of states over time.
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