| 1. |
- Su, Zhan, et al.
(författare)
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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:10
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Tidskriftsartikel (refereegranskat)abstract
- Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined=4.09×10(-9); odds ratio (OR)=1.21, 95% confidence interval (CI)=1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (Pcombined=2.74×10(-10); OR=1.14, 95% CI=1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus.
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| 2. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Arnadottir, Anna, et al.
(författare)
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The Meridian S02E00 : The Winter Solstice special episode
- 2021
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- In this very special solstice episode of The Meridian Nic and Rebecca look back at some of the highlights of 2021. With the days growing ever longer here in the Northern Hemisphere they have rallied a troupe of PhD students to compete in the 2021 Astronomy Games! Nic is joined by Alvaro and Johan on his team and Rebecca has convinced Daniel and Madeleine to join her team. The Games were recorded in front of a live studio audience.
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| 4. |
- Arnadottir, Anna, et al.
(författare)
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The Meridian S03E01 : Human Exploration of Space
- 2023
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Joining Nic and Rebecca in this first episode of the third season of The Meridian is none other than NASA astronaut Jim Pawelczyk, professor at Penn State University in Kinesiology and Physiology, who looks into how the human body adapts when in space.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or trivia from astronomic history that Ross, Victor and Lucian feel are worth bringing out of obscurity for one more look.
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| 5. |
- Arnadottir, Anna, et al.
(författare)
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The Meridian S03E02 : The Hunt for Dark Matter
- 2023
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- We are on a hunt for the invisible in this second episode of the third season of The Meridian. Ruth Pöttgen is a senior lecturer at the Department of Physics where she is studying fundamental particles. She is especially interested in finding that mysterious and elusive Dark Matter particle.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or trivia from astronomic history that Ross, Victor and Lucian feel are worth bringing out of obscurity for one more look.
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| 6. |
- Arnadottir, Anna, et al.
(författare)
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The Meridian S03E03 : Planetary systems beyond our own
- 2023
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Judith Korth joins the podcast this week and tell us about how she found her way into astronomy research, how she ended up here at Lund University and how she now studies distant worlds far beyond our own Solar System.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or trivia from astronomic history that Ross, Victor and Lucian feel are worth bringing out of obscurity for one more look.
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| 7. |
- Arnadottir, Anna, et al.
(författare)
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The Meridian S03E04 : Finding the way using starlight
- 2023
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Astronomers, such as Nic and Rebecca, are not the only ones orienting themselves using the stars. Animals, big and small, also navigate by starlight. In this last episode of the third season we invited Prof. Marie Dacke from the Department of Biology over to tell us about her research on the subject.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or trivia from astronomic history that Ross, Victor and Lucian feel are worth bringing out of obscurity for one more look.
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| 8. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 9. |
- Manni, Giovanni Li, et al.
(författare)
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The OpenMolcas Web : A Community-Driven Approach to Advancing Computational Chemistry
- 2023
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Ingår i: Journal of Chemical Theory and Computation. - : American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 19:20, s. 6933-6991
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Tidskriftsartikel (refereegranskat)abstract
- The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations.
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| 10. |
- Roussakis, Andreas Antonios, et al.
(författare)
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Parkinson’s disease laterality : a 11C-PE2I PET imaging study
- 2020
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Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459.
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Tidskriftsartikel (refereegranskat)abstract
- Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.
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