SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Dan A) "

Sökning: WFRF:(Dan A)

  • Resultat 1-10 av 927
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Thomas, HS, et al. (författare)
  • 2019
  • swepub:Mat__t
  •  
2.
  • 2017
  • swepub:Mat__t
  •  
3.
  •  
4.
  •  
5.
  • Ramdas, S., et al. (författare)
  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
  • 2022
  • Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
  • Tidskriftsartikel (refereegranskat)abstract
    • A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
  •  
6.
  •  
7.
  • Algaba, Juan-Carlos, et al. (författare)
  • Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
  • 2021
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
  • Forskningsöversikt (refereegranskat)abstract
    • In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
  •  
8.
  •  
9.
  • Justice, A. E., et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 927
Typ av publikation
tidskriftsartikel (825)
konferensbidrag (43)
forskningsöversikt (19)
annan publikation (15)
bokkapitel (11)
doktorsavhandling (5)
visa fler...
rapport (3)
samlingsverk (redaktörskap) (2)
konstnärligt arbete (1)
licentiatavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (862)
övrigt vetenskapligt/konstnärligt (62)
populärvet., debatt m.m. (1)
Författare/redaktör
Lorentzon, Mattias, ... (46)
Zhang, J. (44)
Wang, D. (44)
Zhu, Y. C. (44)
Han, S. (44)
Berger, N. (43)
visa fler...
Liu, D. (43)
Gao, Y. (43)
Liu, Q. (43)
Wang, M. (43)
Wang, Z. (43)
Fegan, S. (43)
Lu, Y (43)
Zhao, Q (43)
Liu, X (42)
Cetin, S. A. (42)
Fang, Y. (42)
Jin, S. (42)
Liu, B. (42)
Liu, J. B. (42)
Ouyang, Q. (42)
Peters, K. (42)
Wang, K. (42)
Xu, L. (42)
Zhemchugov, A. (42)
Zhou, L. (42)
Ma, L. L. (42)
Qi, M. (42)
Sun, X. H. (42)
Chen, G. (42)
Wu, Z. (42)
Zeng, Y. (42)
Hu, Y. (42)
Cai, X. (42)
Ferroli, R. Baldini (42)
Li, G. (42)
Pan, Y. (42)
Karlsson, Magnus (42)
Yang, L. (42)
Zhu, S. (42)
Boyko, I. (42)
Dedovich, D. (42)
..., Wiedner U. (42)
Wolke, Magnus (42)
Hussain, T. (42)
Li, H. B. (42)
Ablikim, M. (42)
Zou, J. H. (42)
Pettersson, Joachim (42)
Achasov, M. N. (42)
visa färre...
Lärosäte
Uppsala universitet (368)
Lunds universitet (214)
Göteborgs universitet (185)
Karolinska Institutet (157)
Umeå universitet (126)
Chalmers tekniska högskola (113)
visa fler...
Stockholms universitet (81)
Kungliga Tekniska Högskolan (63)
Linköpings universitet (31)
Mittuniversitetet (23)
Örebro universitet (12)
Högskolan Dalarna (12)
Södertörns högskola (10)
Sveriges Lantbruksuniversitet (9)
Handelshögskolan i Stockholm (8)
Linnéuniversitetet (7)
Luleå tekniska universitet (6)
Malmö universitet (5)
RISE (4)
Naturhistoriska riksmuseet (4)
Jönköping University (3)
Högskolan i Skövde (2)
Högskolan i Borås (2)
Högskolan Kristianstad (1)
Högskolan i Gävle (1)
Karlstads universitet (1)
visa färre...
Språk
Engelska (920)
Svenska (5)
Odefinierat språk (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (408)
Naturvetenskap (351)
Teknik (70)
Samhällsvetenskap (25)
Lantbruksvetenskap (8)
Humaniora (8)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy