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1.	Brueggemann, AB, et al. (author) Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data 2021 In: The Lancet. Digital health. - : Elsevier. - 2589-7500. ; 3:6, s. E360-E370 Journal article (peer-reviewed)
2.	Shaw, D, et al. (author) Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium 2023 In: The Lancet. Digital health. - : Elsevier. - 2589-7500. ; 5:9, s. e582-e593 Journal article (peer-reviewed)
3.	Karwen, T., et al. (author) Platelet-derived lipids promote insulin secretion of pancreatic beta cells 2023 In: Embo Molecular Medicine. - 1757-4676. ; 15:9 Journal article (peer-reviewed)abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic beta cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from beta cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet-derived lipid classes to promote insulin secretion and identified 20-Hydroxyeicosatetraenoic acid (20-HETE) as the main factor promoting beta cells function. Finally, we demonstrate that the levels of platelet-derived 20-HETE decline with age and that this parallels with reduced impact of platelets on beta cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Corcoran, M. (2); Zhou, F. (2); Roberts, M. (2); Meehan, M. (2); Shaw, D (2); Ip, M (2); show more...; Henriques-Normark, B (2); Davies, H (2); Morgan, J (2); Hoffmann, S (2); Johnston, J. (2); Cao, B. (2); Jacobsson, Susanne, ... (2); Lindholm, L (2); Kristinsson, KG (2); Smith, AJ (2); Murphy, J (2); Perry, M. (2); von Gottberg, A (2); Cottrell, S (2); Hilty, M (2); Morfeldt, E. (2); Coelho, J (2); Martin, I (2); Brueggemann, AB (2); Jolley, KA (2); Maiden, MCJ (2); Mölling, Paula, 1971 ... (2); Amin-Chowdhury, Z (2); Broughton, K (2); Casanova, C (2); Choi, EH (2); Chu, YW (2); Claus, H (2); Dalby, T (2); de Gouveia, L (2); Deghmane, AE (2); Demczuk, W (2); Desmet, S (2); du Plessis, M (2); Erlendsdottir, H (2); Fry, NK (2); Fuursted, K (2); Hale, T (2); Humphreys, H (2); Kozakova, J (2); Krizova, P (2); Kuch, A (2); Lam, TT (2); Martiny, D (2); show less...

University: Örebro University (2); Karolinska Institutet (2); University of Gothenburg (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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