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- Abdalla, E., et al.
(författare)
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Cosmology intertwined : A review of the particle physics, astrophysics, and cosmology associated with the cosmological tensions and anomalies
- 2022
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Ingår i: Journal of High Energy Astrophysics. - : Elsevier BV. - 2214-4048 .- 2214-4056. ; 34, s. 49-211
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Tidskriftsartikel (refereegranskat)abstract
- The standard Λ Cold Dark Matter (ΛCDM) cosmological model provides a good description of a wide range of astrophysical and cosmological data. However, there are a few big open questions that make the standard model look like an approximation to a more realistic scenario yet to be found. In this paper, we list a few important goals that need to be addressed in the next decade, taking into account the current discordances between the different cosmological probes, such as the disagreement in the value of the Hubble constant H0, the σ8–S8 tension, and other less statistically significant anomalies. While these discordances can still be in part the result of systematic errors, their persistence after several years of accurate analysis strongly hints at cracks in the standard cosmological scenario and the necessity for new physics or generalisations beyond the standard model. In this paper, we focus on the 5.0σ tension between the Planck CMB estimate of the Hubble constant H0 and the SH0ES collaboration measurements. After showing the H0 evaluations made from different teams using different methods and geometric calibrations, we list a few interesting new physics models that could alleviate this tension and discuss how the next decade's experiments will be crucial. Moreover, we focus on the tension of the Planck CMB data with weak lensing measurements and redshift surveys, about the value of the matter energy density Ωm, and the amplitude or rate of the growth of structure (σ8,fσ8). We list a few interesting models proposed for alleviating this tension, and we discuss the importance of trying to fit a full array of data with a single model and not just one parameter at a time. Additionally, we present a wide range of other less discussed anomalies at a statistical significance level lower than the H0–S8 tensions which may also constitute hints towards new physics, and we discuss possible generic theoretical approaches that can collectively explain the non-standard nature of these signals. Finally, we give an overview of upgraded experiments and next-generation space missions and facilities on Earth that will be of crucial importance to address all these open questions.
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- Fomalont, E. B., et al.
(författare)
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THE 2014 ALMA LONG BASELINE CAMPAIGN: AN OVERVIEW
- 2015
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 808:1
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Tidskriftsartikel (refereegranskat)abstract
- A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to make accurate images with resolutions of tens of milliarcseconds, which at submillimeter (submm) wavelengths requires baselines up to similar to 15 km. To develop and test this capability, a Long Baseline Campaign (LBC) was carried out from 2014 September to late November, culminating in end-to-end observations, calibrations, and imaging of selected Science Verification (SV) targets. This paper presents an overview of the campaign and its main results, including an investigation of the short-term coherence properties and systematic phase errors over the long baselines at the ALMA site, a summary of the SV targets and observations, and recommendations for science observing strategies at long baselines. Deep ALMA images of the quasar 3C 138 at 97 and 241 GHz are also compared to VLA 43 GHz results, demonstrating an agreement at a level of a few percent. As a result of the extensive program of LBC testing, the highly successful SV imaging at long baselines achieved angular resolutions as fine as 19 mas at similar to 350 GHz. Observing with ALMA on baselines of up to 15 km is now possible, and opens up new parameter space for submm astronomy.
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- Hakkaart, C, et al.
(författare)
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Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 1061-
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Tidskriftsartikel (refereegranskat)abstract
- The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biological validation. Notably, the HR for deletions in BRCA1 suggested an elevated breast cancer risk estimate (hazard ratio (HR) = 1.21), 95% confidence interval (95% CI = 1.09–1.35) compared with non-CNV pathogenic variants. In contrast, deletions overlapping SULT1A1 suggested a decreased breast cancer risk (HR = 0.73, 95% CI 0.59-0.91) in BRCA1 pathogenic variant carriers. Functional analyses of SULT1A1 showed that reduced mRNA expression in pathogenic BRCA1 variant cells was associated with reduced cellular proliferation and reduced DNA damage after treatment with DNA damaging agents. These data provide evidence that deleterious variants in BRCA1 plus SULT1A1 deletions contribute to variable breast cancer risk in BRCA1 carriers.
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- Rushton, Anthony, 1983, et al.
(författare)
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A weak compact jet in a soft state of Cygnus X-1
- 2012
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 419:4, s. 3194-3199
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Tidskriftsartikel (refereegranskat)abstract
- We present evidence for the presence of a weak compact jet during a soft X-ray state of Cygnus X-1. Very-high-resolution radio observations were taken with the VLBA, EVN and MERLIN during a hard-to-soft spectral state change, showing the hard state jet to be suppressed by a factor of about 35 in radio flux and unresolved to direct imaging observations (i.e. ?1 mas at 4 cm). High time-resolution X-ray observations with the RXTE-PCA were also taken during the radio monitoring period, showing the source to make the transition from the hard state to a softer state (via an intermediate state), although the source may never have reached the canonical soft state. Using astrometric very long baseline interferometry (VLBI) analysis and removing proper motion, parallax and orbital motion signatures, the residual positions show a scatter of similar to 0.2 mas (at 4 cm) and similar to 3 mas (at 13 cm) along the position angle of the known jet axis; these residuals suggest that there is a weak unresolved outflow, with varying size or opacity, during intermediate and soft X-ray states. Furthermore, no evidence was found for extended knots or shocks forming within the jet during the state transition, suggesting that the change in outflow rate may not be sufficiently high to produce superluminal knots.
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- Rushton, Anthony, 1983, et al.
(författare)
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VLBI constraints on the “Jet-line” of Cygnus X-1
- 2010
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Ingår i: Proceedings of Science. - 1824-8039. ; 125
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Konferensbidrag (refereegranskat)abstract
- Results are presented from recent VLBI observations of Cygnus X-1 during X-ray spectral state changes. Using the EVN in e-VLBI mode and the VLBA with disk recording, we observed the X-ray binary at very high angular resolution and studied changes in the compact jets as the source made transitions from hard X-ray states to softer states. The radio light curves show that these transitions were accompanied by radio flaring events followed by a quenching of the radio emission, as expected from the current paradigm for disc-jet coupling in X-ray binaries. While we see structural changes in the compact jets during these transitions, there was no evidence for the expected ejection of bright, relativistically-moving jet knots. However, we find strong evidence that the jet does not switch off completely in the soft X-ray state of Cygnus X-1, such that a weak, compact jet persists during this phase of radio quenching.
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