| 1. |
|
|
| 2. |
|
|
| 3. |
- Dessne, Petter, et al.
(author)
-
OTEC matters 2015
- 2015
-
Reports (other academic/artistic)abstract
- For mankind as a whole, and in many respects, the world is becoming a better place each year. In both rich and poor countries the standard of living has improved steadily for a very long time. This progress has a serious drawback, the negative effects on Earth’s climate. It is clear that the only way we can live sustainably is by consuming much less. However, this is not enough: there is an undeniable need for new energy sources. As the world’s population grows, many countries will also face more severe shortages of food and of fresh, disease-free water. Most developing countries are situated in tropical regions and are therefore hit hard by increasing tropical storms and similar weather-based disasters, adding to these problems. Ocean Thermal Energy Conversion (OTEC) technology has been proven to be an ideal candidate for addressing and resolving all of these problems for small island developing states (SIDS), and a few months ago, the EU set aside€72 million euros for constructing OTEC plants outside Martinique. Built on a much larger scale, OTEC can, as the only technology known to man, supply the world with its total energy and fresh water needs, increase seafood production many times over, and cooling off parts of the sea surface when they become too hot – all this without any atmospheric emissions. Thus, it is with great excitement that this very first issue of the only journal dedicated to OTEC is being published. The publication covers many facets of OTEC and related matters, such as OTEC technology, sustainability including gender and other social studies, renewable energy, marine biology, metallurgy, and research on developing countries. The publication is aimed at two different audiences, scientists directly or indirectly involved with OTEC technology, and a more diverse group of people consisting of scientists from non-technical fields, industry people, politicians, investors, educators, and more. This volume is published as part of the publication series of the University of Borås, a progressive Swedish university with a high interest in and knowledge about sustainability.
|
|
| 4. |
|
|
| 5. |
- Groß, M., et al.
(author)
-
Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity
- 2022
-
In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 149:1, s. 388-399
-
Journal article (peer-reviewed)abstract
- Background: Rubella virus–induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. Objective: This study sought to understand the defective effector mechanism allowing rubella vaccine virus persistence in granulomas. Methods: Starting from an index case with Griscelli syndrome type 2 and rubella skin granulomas, this study combined an international survey with a literature search to identify patients with cytotoxicity defects and granuloma. The investigators performed rubella virus immunohistochemistry and PCR and T-cell migration assays. Results: This study identified 21 patients with various genetically confirmed cytotoxicity defects, who presented with skin and visceral granulomas. Rubella virus was demonstrated in all 12 accessible biopsies. Granuloma onset was typically before 2 years of age and lesions persisted from months to years. Granulomas were particularly frequent in MUNC13-4 and RAB27A deficiency, where 50% of patients at risk were affected. Although these proteins have also been implicated in lymphocyte migration, 3-dimensional migration assays revealed no evidence of impaired migration of patient T cells. Notably, patients showed no evidence of reduced control of concomitantly given measles, mumps, or varicella live-attenuated vaccine or severe infections with other viruses. Conclusions: This study identified lymphocyte cytotoxicity as a key effector mechanism for control of rubella vaccine virus, without evidence for its need in control of live measles, mumps, or varicella vaccines. Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic disorders of cytotoxicity. © 2021 American Academy of Allergy, Asthma & Immunology
|
|
