| 1. |
|
|
| 2. |
- Abdalla, H., et al.
(författare)
-
Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
- 2021
-
Ingår i: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics Publishing (IOPP). - 1475-7516. ; :2
-
Tidskriftsartikel (refereegranskat)abstract
- The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for gamma-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of gamma-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of gamma-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z = 2 and to constrain or detect gamma-ray halos up to intergalactic-magnetic-field strengths of at least 0.3 pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from gamma-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of gamma-ray cosmology.
|
|
| 3. |
|
|
| 4. |
- von Doetinchem, P., et al.
(författare)
-
Cosmic-ray antinuclei as messengers of new physics : status and outlook for the new decade
- 2020
-
Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :8
-
Tidskriftsartikel (refereegranskat)abstract
- The precise measurement of cosmic-ray antinuclei serves as an important means for identifying the nature of dark matter and other new astrophysical phenomena, and could be used with other cosmic-ray species to understand cosmic-ray production and propagation in the Galaxy. For instance, low-energy antideuterons would provide a "smoking gun" signature of dark matter annihilation or decay, essentially free of astrophysical background. Studies in recent years have emphasized that models for cosmic-ray antideuterons must be considered together with the abundant cosmic antiprotons and any potential observation of antihelium. Therefore, a second dedicated Antideuteron Workshop was organized at UCLA in March 2019, bringing together a community of theorists and experimentalists to review the status of current observations of cosmic-ray antinuclei, the theoretical work towards understanding these signatures, and the potential of upcoming measurements to illuminate ongoing controversies. This review aims to synthesize this recent work and present implications for the upcoming decade of antinuclei observations and searches. This includes discussion of a possible dark matter signature in the AMS-02 antiproton spectrum, the most recent limits from BESS Polar-II on the cosmic antideuteron flux, and reports of candidate antihelium events by AMS-02; recent collider and cosmic-ray measurements relevant for antinuclei production models; the state of cosmic-ray transport models in light of AMS-02 and Voyager data; and the prospects for upcoming experiments, such as GAPS. This provides a roadmap for progress on cosmic antinuclei signatures of dark matter in the coming years.
|
|
| 5. |
- De La Torre Luque, Pedro, et al.
(författare)
-
Galactic diffuse gamma rays meet the PeV frontier
- 2023
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 672
-
Tidskriftsartikel (refereegranskat)abstract
- Context. The Tibet AS gamma and LHAASO collaborations recently reported the observation of a gamma-ray diffuse emission with energy up to the PeV level from the Galactic plane.Aims. We discuss the relevance of non-uniform cosmic-ray transport scenarios and the implications of these results for cosmic-ray physics.Methods. We used the DRAGON and HERMES codes to build high-resolution maps and spectral distributions of that emission for several representative models under the condition that they reproduce a wide set of local cosmic-ray data up to 100 PeV.Results. We show that the energy spectra measured by Tibet AS gamma, LHAASO, ARGO-YBJ, and Fermi-LAT in several regions of interest in the sky can all be reasonably described in terms of the emission arising by the Galactic cosmic-ray sea. We also show that all our models are compatible with IceTop gamma-ray upper limits.Conclusions. We compare the predictions of conventional and space-dependent transport models with those data sets. Although the Fermi-LAT, ARGO-YBJ, and LHAASO preliminary data slightly favor this scenario, due to the still large experimental errors, the poorly known source spectral shape at the highest energies, the potential role of spatial fluctuations in the leptonic component, and a possible larger-than-expected contamination due to unresolved sources, a solid confirmation requires further investigations. We discuss which measurements will be most relevant in order to resolve the remaining degeneracy.
|
|
| 6. |
- Vergoossen, Dana L. E., et al.
(författare)
-
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
- 2022
-
Ingår i: Journal of Neuroimmunology. - : Elsevier. - 0165-5728 .- 1872-8421. ; 373
-
Tidskriftsartikel (refereegranskat)abstract
- Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a neuromuscular autoimmune disease belonging to a growing group of IgG4 autoimmune diseases (IgG4-AIDs), in which the majority of pathogenic autoantibodies are of the IgG4 subclass. The more prevalent form of MG with acetylcholine receptor (AChR) antibodies is caused by IgG1-3 autoantibodies. A dominant role for IgG4 in autoimmune disease is intriguing due to its antiinflammatory characteristics. It is unclear why MuSK autoantibodies are predominantly IgG4. We hypothesized that MuSK MG patients have a general predisposition to generate IgG4 responses, therefore resulting in high levels of circulating IgG4. To investigate this, we quantified serum Ig isotypes and IgG subclasses using nephelometric and turbidimetric assays in MuSK MG and AChR MG patients not under influence of immunosuppressive treatment. Absolute serum IgG1 was increased in both MuSK and AChR MG patients compared to healthy donors. In addition, only MuSK MG patients on average had significantly increased and enriched serum IgG4. Although more MuSK MG patients had elevated serum IgG4, for most the IgG4 serum levels fell within the normal range. Correlation analyses suggest MuSK-specific antibodies do not solely explain the variation in IgG4 levels. In conclusion, although serum IgG4 levels are slightly increased, the levels do not support ubiquitous IgG4 responses in MuSK MG patients as the underlying cause of dominant IgG4 MuSK antibodies.
|
|
| 7. |
|
|
