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Sökning: WFRF:(Foyer Julia)

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1.
  • Lázár, Enikő, et al. (författare)
  • Spatial Dynamics of the Developing Human Heart
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Heart development relies on a topologically defined interplay between a diverse array of cardiac cells. We finely curated spatial and single-cell measurements with subcellular imaging-based transcriptomics validation to explore spatial dynamics during early human cardiogenesis. Analyzing almost 80,000 individual cells and 70,000 spatially barcoded tissue regions between the 5.5th and 14th postconceptional weeks, we identified 31 coarse- and 72 fine-grained cell states and mapped them to highly resolved cardiac cellular niches. We provide novel insight into the development of the cardiac pacemaker-conduction system, heart valves, and atrial septum, and decipher heterogeneity of the hitherto elusive cardiac fibroblast population. Furthermore, we describe the formation of cardiac autonomic innervation and present the first spatial account of chromaffin cells in the fetal human heart. In summary, our study delineates the cellular and molecular landscape of the developing heart’s architecture, offering links to genetic causes of heart disease.
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2.
  • Vicari, Marco, et al. (författare)
  • Spatial multimodal analysis of transcriptomes and metabolomes in tissues
  • 2023
  • Ingår i: Nature Biotechnology. - 1087-0156 .- 1546-1696.
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson’s disease.
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