| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Galluzzi, L, et al.
(författare)
-
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- 2020
-
Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:1
-
Tidskriftsartikel (refereegranskat)abstract
- Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Fares, Hssen, et al.
(författare)
-
Tuning multicolor emission in AgNCs/Tm3+/Mn2+-doped fluorophosphate glasses
- 2020
-
Ingår i: Journal of Non-Crystalline Solids. - : Elsevier BV. - 0022-3093. ; 535
-
Tidskriftsartikel (refereegranskat)abstract
- Herein we report the synthesis of highly-doped silver nanocluster in fluorophosphate glasses through the melting-quenching method in order to achieve sensitization with Tm3+ and Mn2+ ions. Blue and red emission belonging to Tm3+ (470 to 490 nm) and Mn2+ (550 to 750 nm) ions could be obtained via non-resonant excitation of Tm3+ and Mn2+. Slight decrease of the fluorescence decay times confirmed an energy transfer as a possible mechanism to explain the Tm3+ and Mn2+ emission. The composition of 5 mol% of AgNO3, 0.4 mol% of Tm2O3 and 0.2 mol% of MnF2 in our sample leads to distance between donor (silver nanoclusters) and acceptor (Tm3+-Mn2+) as short as 11 Å, which suggests that the main mechanism for blue and red emission from Tm3+ and Mn2+ is Förster Resonance Energy Transfer (FRET). The results presented here show that the studied material has potential application for multicolor generation as luminophore in white light emitting diodes (W-LED).
|
|
| 8. |
- Fucikova, J, et al.
(författare)
-
Calreticulin and cancer
- 2021
-
Ingår i: Cell research. - : Springer Science and Business Media LLC. - 1748-7838 .- 1001-0602. ; 31:1, s. 5-16
-
Tidskriftsartikel (refereegranskat)
|
|
| 9. |
- Fucikova, J, et al.
(författare)
-
Detection of immunogenic cell death and its relevance for cancer therapy
- 2020
-
Ingår i: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 11:11, s. 1013-
-
Tidskriftsartikel (refereegranskat)abstract
- Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by the exposure and release of numerous damage-associated molecular patterns (DAMPs), which altogether confer a robust adjuvanticity to dying cancer cells, as they favor the recruitment and activation of antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) as well as secreted ATP, annexin A1 (ANXA1), type I interferon, and high-mobility group box 1 (HMGB1). Additional hallmarks of ICD encompass the phosphorylation of eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known as eIF2α), the activation of autophagy, and a global arrest in transcription and translation. Here, we outline methodological approaches for measuring ICD markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
|
|
| 10. |
|
|
